Výsledky vyhledávání - "José M Benito"

Akademický článek

Genetic variation in CCR2 and CXCL12 genes impacts on CD4 restoration in patients initiating cART with advanced immunesupression.

Autor: Clara Restrepo, Mónica Gutierrez-Rivas, Yolanda M Pacheco, Marcial García, Julià Blanco, Luz M Medrano, María A Navarrete-Muñoz, Félix Gutiérrez, Pilar Miralles, David Dalmau, Juan Luis Gómez, Miguel Górgolas, Alfonso Cabello, Salvador Resino, José M Benito, Norma Rallón, CoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS/EPICLIN 10_

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0214421 (2019)

OBJECTIVE:We investigated the association of genetic polymorphisms in chemokine and chemokine receptor genes with poor immunological recovery in HIV patients starting combined antiretroviral therapy (cART) with low CD4 T-cell counts. METHODS:A case-c

Externí odkaz: https://doaj.org/article/6941a2efbcab4475957b11d514d19ab5

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Akademický článek

Expression of PD-1 and Tim-3 markers of T-cell exhaustion is associated with CD4 dynamics during the course of untreated and treated HIV infection.

Autor: Norma Rallón, Marcial García, Javier García-Samaniego, Alfonso Cabello, Beatriz Álvarez, Clara Restrepo, Sara Nistal, Miguel Górgolas, José M Benito

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0193829 (2018)

T-cell exhaustion has been involved in the pathogenesis of HIV infection. We have longitudinally analyzed PD1 and Tim3 surrogate markers of T-cells exhaustion, in parallel with other markers of HIV progression, and its potential association with CD4

Externí odkaz: https://doaj.org/article/1b5ad4b888414921a29b5cea9eac47ee

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Akademický článek

HCV coinfection contributes to HIV pathogenesis by increasing immune exhaustion in CD8 T-cells.

Autor: Norma Rallón, Marcial García, Javier García-Samaniego, Noelia Rodríguez, Alfonso Cabello, Clara Restrepo, Beatriz Álvarez, Rosa García, Miguel Górgolas, José M Benito

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0173943 (2017)

BACKGROUND:There are several contributors to HIV-pathogenesis or insufficient control of the infection. However, whether HIV/HCV-coinfected population exhibits worst evolution of HIV-pathogenesis remains unclear. Recently, some markers of immune exha

Externí odkaz: https://doaj.org/article/58c9a6ea2efc48e693dd7e8d625c7345

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Akademický článek

Immune checkpoint inhibitors as potential therapy for reverting T-cell exhaustion and reverting HIV latency in people living with HIV

Autor: José M. Benito, Clara Restrepo, Jesús García-Foncillas, Norma Rallón

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

The immune system of people living with HIV (PLWH) is persistently exposed to antigens leading to systemic inflammation despite combination antiretroviral treatment (cART). This inflammatory milieu promotes T-cell activation and exhaustion. Furthermo

Externí odkaz: https://doaj.org/article/a7b307119186420eac3802d288dc0ce9

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Akademický článek

High frequency of CD8 escape mutations in elite controllers as new obstacle for HIV cure

Autor: María A. Navarrete-Muñoz, Ricardo Ramos, África Holguín, Alfonso Cabello, Miguel Górgolas, José M. Benito, Norma Rallón

Publikováno v: Virulence, Vol 13, Iss 1, Pp 1713-1719 (2022)

Accumulation of mutations in epitopes of cytolytic-T-lymphocytes immune response (CTL) in HIV-reservoir seems to be one of the reasons for shock-and-kill strategy failure. Ten non-controller patients on successful cART (TX) and seven elite controller

Externí odkaz: https://doaj.org/article/cee6cd801afd42a686523d950160d55b

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Akademický článek

Liver Stiffness Hinders Normalization of Systemic Inflammation and Endothelial Activation after Hepatitis C Virus (HCV) Eradication in HIV/HCV Coinfected Patients

Autor: Beatriz Álvarez, Clara Restrepo, Marcial García, María A. Navarrete-Muñoz, María A. Jiménez-Sousa, Laura Prieto, Alfonso Cabello, Sara Nistal, Salvador Resino, Miguel Górgolas, Norma Rallón, José M. Benito

Publikováno v: Vaccines, Vol 8, Iss 2, p 323 (2020)

Systemic inflammation, endothelial dysfunction and coagulopathy are of high clinical relevance in the management of people living with HIV (PLWH), and even more in patients coinfected with hepatitis C virus (HCV). It has been suggested a significant

Externí odkaz: https://doaj.org/article/e049e8feaa90454897168bab7a108ce1

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Neutrophil β

Autor: Agustín, Clemente-Moragón, Eduardo, Oliver, Daniel, Calle, Lorena, Cussó, Mónica, Gómez, Jesús M, Pradillo, Raquel, Castejón, Norma, Rallón, José M, Benito, José C, Fernández-Ferro, Joaquín, Carneado-Ruíz, María A, Moro, Javier, Sánchez-González, Valentín, Fuster, Marta, Cortés-Canteli, Manuel, Desco, Borja, Ibáñez

Publikováno v: British journal of pharmacologyREFERENCES.

Reperfusion therapy is the standard of care for ischaemic stroke; however, there is a need to identify new therapeutic targets able to ameliorate cerebral damage. Neutrophil βRats were subjected to middle cerebral artery occlusion-reperfusion to eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::317f18a73db010b2a9153b8758483f66
https://pubmed.ncbi.nlm.nih.gov/36181002

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