Zobrazeno 1 - 10
of 38
pro vyhledávání: '"José M, Muñoz-Félix"'
Autor:
Iván Carrera-Aguado, Laura Marcos-Zazo, Patricia Carrancio-Salán, Elena Guerra-Paes, Fernando Sánchez-Juanes, José M. Muñoz-Félix
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 921 (2024)
Vessel co-option (VCO) is a non-angiogenic mechanism of vascularization that has been associated to anti-angiogenic therapy. In VCO, cancer cells hijack the pre-existing blood vessels and use them to obtain oxygen and nutrients and invade adjacent ti
Externí odkaz:
https://doaj.org/article/c6ebe9533eb54ff68381fb7ae77204da
Autor:
Tanguy Lechertier, Louise E. Reynolds, Hyojin Kim, Ana Rita Pedrosa, Jesús Gómez-Escudero, José M. Muñoz-Félix, Silvia Batista, Matthew Dukinfield, Fevzi Demircioglu, Ping Pui Wong, Kylie P. Matchett, Neil C. Henderson, Gabriela D’Amico, Maddy Parsons, Catherine Harwood, Pascal Meier, Kairbaan M. Hodivala-Dilke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/33e6176c6d6a4fc595fff02b19cc1f2f
Autor:
Carlos Martínez-Salgado, Fernando Sánchez-Juanes, Francisco J. López-Hernández, José M. Muñoz-Félix
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Renal tubulo-interstitial fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) in the tubular interstitium during chronic kidney disease. The main source of ECM proteins are emerging and proliferating myofibroblasts.
Externí odkaz:
https://doaj.org/article/da9308c0ed9e4e929bf46db476b4ac64
Autor:
Tanguy Lechertier, Louise E. Reynolds, Hyojin Kim, Ana Rita Pedrosa, Jesús Gómez-Escudero, José M. Muñoz-Félix, Silvia Batista, Matthew Dukinfield, Fevzi Demircioglu, Ping Pui Wong, Kylie P. Matchett, Neil C. Henderson, Gabriela D’Amico, Maddy Parsons, Catherine Harwood, Pascal Meier, Kairbaan M. Hodivala-Dilke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Abstract The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is unknown. We show tha
Externí odkaz:
https://doaj.org/article/327b0c1e155a4263840ab94acda7cb38
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
Pathological angiogenesis contributes to tumour progression as well as to chronic inflammatory diseases. In this issue of EMBO Molecular Medicine, Esteban and co‐workers identify endothelial cell MT1‐MMP as a key regulator of intussusceptive angi
Externí odkaz:
https://doaj.org/article/3acbc696ba2e4167ac0ce71b2c4c8860
Autor:
Emma L. Newport, Ana Rita Pedrosa, Alexandra Njegic, Kairbaan M. Hodivala-Dilke, José M. Muñoz-Félix
Publikováno v:
Cancers, Vol 13, Iss 20, p 5207 (2021)
Several strategies have been developed to modulate the tumour vasculature for cancer therapy including anti-angiogenesis and vascular normalisation. Vasculature modulation results in changes to the tumour microenvironment including oxygenation and im
Externí odkaz:
https://doaj.org/article/68f7e403296145e89f98cacb33b45cbe
Publikováno v:
Cancers, Vol 13, Iss 21, p 5412 (2021)
The improvement of cancer therapy efficacy, the extension of patient survival and the reduction of adverse side effects are major challenges in cancer research. Targeting blood vessels has been considered a promising strategy in cancer therapy. Since
Externí odkaz:
https://doaj.org/article/0043a30176fb45b1b342110cadd8cd4f
Publikováno v:
Genes, Vol 12, Iss 6, p 800 (2021)
Many different regulatory mechanisms of renal fibrosis are known to date, and those related to transforming growth factor-β1 (TGF-β1)-induced signaling have been studied in greater depth. However, in recent years, other signaling pathways have been
Externí odkaz:
https://doaj.org/article/f52bc5b6c07747ccac5c5c034547d204
Autor:
Carlos Martínez-Salgado, Fernando Sánchez-Juanes, Francisco J. López-Hernández, José M. Muñoz-Félix
Publikováno v:
Frontiers in pharmacology. 13
Renal tubulo-interstitial fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) in the tubular interstitium during chronic kidney disease. The main source of ECM proteins are emerging and proliferating myofibroblasts.
Autor:
Ana Rita Pedrosa, Emma Newport, Alexandra Njegic, José M. Muñoz-Félix, Kairbaan Hodivala-Dilke
Publikováno v:
Cancers, Vol 13, Iss 5207, p 5207 (2021)
Cancers
Cancers
Simple Summary Although immunotherapy has given the highest rate of improvement in cancer treatment in recent years, there is an urgent need to further improve its efficacy. Numerous strategies aim to transform non-responsive, immunosuppressive tumou