Zobrazeno 1 - 10
of 156
pro vyhledávání: '"José M, Benito"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The immune system of people living with HIV (PLWH) is persistently exposed to antigens leading to systemic inflammation despite combination antiretroviral treatment (cART). This inflammatory milieu promotes T-cell activation and exhaustion. Furthermo
Externí odkaz:
https://doaj.org/article/a7b307119186420eac3802d288dc0ce9
Autor:
María A. Navarrete-Muñoz, Ricardo Ramos, África Holguín, Alfonso Cabello, Miguel Górgolas, José M. Benito, Norma Rallón
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 1713-1719 (2022)
Accumulation of mutations in epitopes of cytolytic-T-lymphocytes immune response (CTL) in HIV-reservoir seems to be one of the reasons for shock-and-kill strategy failure. Ten non-controller patients on successful cART (TX) and seven elite controller
Externí odkaz:
https://doaj.org/article/cee6cd801afd42a686523d950160d55b
Autor:
Beatriz Álvarez, María A. Navarrete-Muñoz, Veronica Briz, Susana Olmedillas-López, Sara Nistal, Alfonso Cabello, Laura Prieto, Miguel Górgolas, Mariano García-Arranz, José M. Benito, Norma Rallón
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-5 (2022)
Abstract The role of HCV on the HIV reservoir is controversial since the reduction on HIV-DNA levels after HCV eradication with IFNα/RBV treatment seems to be the result of drugs instead of HCV clearance. We assessed whether HCV eradication can decr
Externí odkaz:
https://doaj.org/article/36b728d6fa7c41d585b7b6f569c1acbc
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 889-897 (2020)
The exceptional group of ECs has been of great help, and will continue to provide invaluable insight with regard to reach a potential functional cure of HIV. However, there is no consensus on the immune correlates associated to this EC phenotype whic
Externí odkaz:
https://doaj.org/article/067628ee7d614729a9bc03f9f294f5a5
Autor:
Jenifer Masip, Norma Rallón, Elena Yeregui, Montserrat Olona, Salvador Resino, José M. Benito, Consuelo Viladés, Graciano García-Pardo, José Alcamí, Ezequiel Ruiz-Mateos, Frederic Gómez-Bertomeu, Montserrat Vargas, Marta Navarro, José A. Oteo, Juan A. Pineda, Anna Martí, Verónica Alba, Francesc Vidal, Joaquin Peraire, Anna Rull
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are sti
Externí odkaz:
https://doaj.org/article/5cd75fe1c3ed498383bd4475a43f5cdd
Autor:
Daniel Sepúlveda-Crespo, Norma Rallón, María José Muñoz-Gómez, Oscar Brochado-Kith, José Luis Jiménez, María Ángeles Muñoz-Fernández, José M. Benito, Salvador Resino
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Human immunodeficiency virus-1 (HIV-1) elite controllers are heterogeneous due to different immunovirological features. We aimed to identify plasma biomarkers associated with loss of spontaneous HIV-1 control in long-term elite controllers (HIV-LTECs
Externí odkaz:
https://doaj.org/article/3234532325eb493eaa53696642076a20
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Combination antiretroviral therapy (cART) effectively blocks HIV replication but cannot completely eliminate HIV from the body mainly due to establishment of a viral reservoir. To date, clinical strategies designed to replace cART for life and altern
Externí odkaz:
https://doaj.org/article/6b9769b5c43f4b82920ff335ca390b75
DBP rs7041 and DHCR7 rs3829251 are Linked to CD4+ Recovery in HIV Patients on Antiretroviral Therapy
Autor:
Salvador Resino, María Ángeles Jiménez-Sousa, Julià Blanco, Yolanda M. Pacheco, Jorge del Romero, Joaquim Peraire, Ana Virseda-Berdices, María José Muñoz-Gómez, Carlos Galera-Peñaranda, Lucio Jesus García-Fraile, José M. Benito, Norma Rallón
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Background: The lack of the recovery of CD4+ T-cells (CD4+ recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (
Externí odkaz:
https://doaj.org/article/59a3d604aaf24ddba2ceeacd09f08f52
Autor:
María J. Ruiz-de-León, María A. Jiménez-Sousa, Santiago Moreno, Marcial García, Mónica Gutiérrez-Rivas, Agathe León, Marta Montero-Alonso, Juan González-García, Salvador Resino, Norma Rallón, José M. Benito, Alejandro Vallejo, J.M. Benito, N. Rallón, C. Restrepo, N. Rodríguez, M. García, A. Cabello, M. Gorgolas, S. Resino, V. Briz, M.A. Jiménez, M.S. Vázquez, A. Fernández, P. García, M.A. Muñoz, J. Sánchez, J.L. Jiménez, D. Sepúlveda, I. García, I. Consuegra, A. León, M. Arnedo, M. Plana, N. Climent, F. García, E. Ruiz-Mateos, B. Domínguez, L. Tarancón, M. Rafii-El-Idrissi, M.J. Polaino, M. Genebat, P. Viciana, M. Leal, F. Vidal, E. Rodríguez, C. Viladés, J. Peraire, J. Romero, C Rodríguez, M. Vera, J. Esté, E. Ballana, M.A. Martínez, S. Franco, M. Nevot, A. Vallejo, S. Moreno, M. Pernas, C. Casado, C. López, L. Capa, M. Pérez, J. Alcami, R. Sanjuán, J.M. Cueva, R. Delgado, O. Sierra, A. Valenzuela
Publikováno v:
Journal of Microbiology, Immunology and Infection, Vol 52, Iss 4, Pp 667-671 (2019)
Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137–0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.64
Externí odkaz:
https://doaj.org/article/725133f9f4b2422c80fc1f2b7486abb8
Autor:
Luz M. Medrano, Mónica Gutiérrez-Rivas, Julià Blanco, Marcial García, María A. Jiménez-Sousa, Yolanda M. Pacheco, Marta Montero, José Antonio Iribarren, Enrique Bernal, Onofre Juan Martínez, José M. Benito, Norma Rallón, Salvador Resino, CoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS/EPICLIN 10_
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-8 (2018)
Abstract Background The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination an
Externí odkaz:
https://doaj.org/article/89d9b98cbe174516a9f90c43c859b2f7