Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoids.

Autor: Carlota A García-Domínguez, Natalia Martínez, Teresa Gragera, Andrea Pérez-Rodríguez, Diana Retana, Gonzalo León, Agustín Sánchez, José Luis Oliva, Dolores Pérez-Sala, José M Rojas

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e16787 (2011)

Sprouty and Spred proteins have been widely implicated in the negative regulation of the fibroblast growth factor receptor-extracellular regulated kinase (ERK) pathway. In considering the functional role of these proteins, we explored their effects o

Externí odkaz: https://doaj.org/article/48e19c28ab1c458eae1f03da80e9dcd9

Investigation of Enantioselectivity Using TADDOL Derivatives as Chiral Ligands in Asymmetric Cyanation Reactions

Autor: Tushar Janardan Pawar, J. Oscar C. Jimenez-Halla, Darien I. Martinez-Valencia, Siddhant V. Kokate, Enrique Delgado-Alvarado, José Luis Olivares-Romero

Publikováno v: ACS Omega, Vol 9, Iss 26, Pp 29035-29040 (2024)

Externí odkaz: https://doaj.org/article/26dc54199cb0440b9304d406feb10783

The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein

Autor: Alberto Fernández-Medarde, Alicia Ballester, B. Anta, Begoña Anta, Ana Belén Cámara, María Pilar de Lucas, Eugenio Santos, José M. Rojas-Cabañeros, José Luis Oliva, Natasha Zarich

Publikováno v: Oncogenesis
Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Oncogenesis, Vol 8, Iss 1, Pp 1-11 (2019)

© The Author(s) 2018.
Sos1 is an universal, widely expressed Ras guanine nucleotide-exchange factor (RasGEF) in eukaryotic cells. Its N-terminal HD motif is known to be involved in allosteric regulation of Sos1 GEF activity through intramolecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01ad6c76e5a4cc857f014bbcab615bf
http://hdl.handle.net/10261/203936

The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras

Autor: Susana García-Vargas, Natalia Martínez, Angeles Juarranz, Rocío Jorge, José Luis Oliva, Antonio Castrillo, Natasha Zarich, Marta Azañedo, Silvia Gutiérrez-Eisman, J. Silvio Gutkind, Lisardo Boscá, José M. Rojas

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)

Retraction in: The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras. [J Biol Chem. 2018] Ras proteins (H-, N-, and K-Ras) operate as molecular switches in signal transduction cascades controlling ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee165451192226c01d36019d7d58683
https://pubmed.ncbi.nlm.nih.gov/15181015

PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability

Autor: Natalia Martínez, Teresa Gragera, María Pilar de Lucas, Ana Belén Cámara, Alicia Ballester, Berta Anta, Alberto Fernández-Medarde, Tania López-Briones, Judith Ortega, Daniel Peña-Jiménez, Antonio Barbáchano, Ana Montero-Calle, Víctor Cordero, Rodrigo Barderas, Teresa Iglesias, Mónica Yunta, José Luís Oliva, Alberto Muñoz, Eugenio Santos, Natasha Zarich, José M. Rojas-Cabañeros

Publikováno v: Oncogenesis, Vol 12, Iss 1, Pp 1-10 (2023)

Abstract Spry2 is a molecular modulator of tyrosine kinase receptor signaling pathways that has cancer-type-specific effects. Mammalian Spry2 protein undergoes tyrosine and serine phosphorylation in response to growth factor stimulation. Spry2 expres

Externí odkaz: https://doaj.org/article/bbe6116d95ad4073950b5d652b6cd1b6