Zobrazeno 1 - 10
of 11
pro vyhledávání: '"José Luis Neira"'
Autor:
Patricia Santofimia-Castaño, Yi Xia, Ling Peng, Adrián Velázquez-Campoy, Olga Abián, Wenjun Lan, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Philippe Soubeyran, José Luis Neira, Juan Iovanna
Publikováno v:
Cells, Vol 8, Iss 11, p 1453 (2019)
Cancer cells activate stress-response mechanisms to adapt themselves to a variety of stressful conditions. Among these protective mechanisms, those controlled by the stress-induced nuclear protein 1 (NUPR1) belong to the most conserved ones. NUPR1 is
Externí odkaz:
https://doaj.org/article/8ff2c387478440128970dd8184627d99
Autor:
Juan Iovanna, José Luis Neira
Publikováno v:
The Scientific World Journal, Vol 10, Pp 1967-1970 (2010)
Pancreatic cancer (PC) is the fourth leading cause of cancer death, with a median survival of 6 months and a dismal 5-year survival rate of 35%, a figure which has remained relatively unchanged over the past 25 years. PC is one of the most difficult
Externí odkaz:
https://doaj.org/article/a4a744625f044ed69a5cd253fdef00af
Autor:
Rebeca Bocanegra, María Nevot, Rosa Doménech, Inmaculada López, Olga Abián, Alicia Rodríguez-Huete, Claudio N Cavasotto, Adrián Velázquez-Campoy, Javier Gómez, Miguel Ángel Martínez, José Luis Neira, Mauricio G Mateu
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23877 (2011)
Virus capsid assembly constitutes an attractive target for the development of antiviral therapies; a few experimental inhibitors of this process for HIV-1 and other viruses have been identified by screening compounds or by selection from chemical lib
Externí odkaz:
https://doaj.org/article/f05692aa4e6b4c5689ff07931322ec5e
Autor:
Pablo Sobrado, José Luis Neira
Publikováno v:
Archives of Biochemistry and Biophysics. 742:109635
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ae9ae12afc8e9aa45e0876248e112a4
https://doi.org/10.1016/j.abb.2023.109635
https://doi.org/10.1016/j.abb.2023.109635
Autor:
Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 475-505 (2024)
Abstract We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven LLPS was crucial for the creation of NUPR1-dependent stress granules (SGs) in pancr
Externí odkaz:
https://doaj.org/article/d6378f109e874a1da4c8222d7dc3b37c
Autor:
Patricia Santofimia-Castaño, Can Huang, Xi Liu, Yi Xia, Stephane Audebert, Luc Camoin, Ling Peng, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
NUPR1 binds to PARP1 and inhibits PARP1 activity in pancreatic cancer cells, with the NUPR1 inhibitor ZZW-115 abolishing the protective effect of NUPR1, inducing strong hyperPARylation and cell death by mitochondrial dysfunction.
Externí odkaz:
https://doaj.org/article/d4dff7ea9c1b4d8c96c31f2f85e4a617
Autor:
Can Huang, Patricia Santofimia-Castaño, Xi Liu, Yi Xia, Ling Peng, Célia Gotorbe, Jose Luis Neira, Daolin Tang, Jacques Pouyssegur, Juan Iovanna
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Ferroptosis is an iron-dependent cell death characterized by the accumulation of hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be pre
Externí odkaz:
https://doaj.org/article/6083bf2904f24594a4f34135a8c074d4
Publikováno v:
Journal of Molecular Biology. 254:289-304
There is a region of well-ordered structure in the transition state of folding of chymotrypsin inhibitor 2 (CI2) that consists of N-terminal residues in the unique alpha-helix (residues 12 to 24) plus some long range interactions, in particular those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18429a02952da06cd579ba105ffdf8e8
https://doi.org/10.1006/jmbi.1995.0617
https://doi.org/10.1006/jmbi.1995.0617
Publikováno v:
The Journal of biological chemistry. 283(5)
Flavodoxin is an essential protein for Helicobacter pylori, a pathogen living in the very acidic environment of the gastric tract and responsible for several diseases. We report the conformational stability of the protein in neutral and acidic pH. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d576bd5dbf3b755bebd21fc6579c70f
https://pubmed.ncbi.nlm.nih.gov/17998211
https://pubmed.ncbi.nlm.nih.gov/17998211
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123463 (2015)
Erb1 (Eukaryotic Ribosome Biogenesis 1) protein is essential for the maturation of the ribosomal 60S subunit. Functional studies in yeast and mammalian cells showed that altogether with Nop7 and Ytm1 it forms a stable subcomplex called PeBoW that is
Externí odkaz:
https://doaj.org/article/d9ae83928fc4493d951fb284119a71f4