The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation.

Autor: Tiziana Ginex, Clara Marco-Marín, Miłosz Wieczór, Carlos P Mata, James Krieger, Paula Ruiz-Rodriguez, Maria Luisa López-Redondo, Clara Francés-Gómez, Roberto Melero, Carlos Óscar Sánchez-Sorzano, Marta Martínez, Nadine Gougeard, Alicia Forcada-Nadal, Sara Zamora-Caballero, Roberto Gozalbo-Rovira, Carla Sanz-Frasquet, Rocío Arranz, Jeronimo Bravo, Vicente Rubio, Alberto Marina, IBV-Covid19-Pipeline, Ron Geller, Iñaki Comas, Carmen Gil, Mireia Coscolla, Modesto Orozco, José Luis Llácer, Jose-Maria Carazo

Publikováno v: PLoS Pathogens, Vol 18, Iss 7, p e1010631 (2022)

The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific e

Externí odkaz: https://doaj.org/article/2ac3186a08434f9d9f6e2286ac7350ff

The PII-NAGK-PipX-NtcA Regulatory Axis of Cyanobacteria: A Tale of Changing Partners, Allosteric Effectors and Non-covalent Interactions

Autor: Alicia Forcada-Nadal, José Luis Llácer, Asunción Contreras, Clara Marco-Marín, Vicente Rubio

Publikováno v: Frontiers in Molecular Biosciences, Vol 5 (2018)

PII, a homotrimeric very ancient and highly widespread (bacteria, archaea, plants) key sensor-transducer protein, conveys signals of abundance or poorness of carbon, energy and usable nitrogen, converting these signals into changes in the activities

Externí odkaz: https://doaj.org/article/310ed886673e409dbf471e7ea5d24516

Δ 1 ‐Pyrroline‐5‐carboxylate synthetase deficiency: An emergent multifaceted urea cycle‐related disorder

Autor: Vicente Rubio, Juan Manuel Escamilla-Honrubia, Marco Seri, Clara Marco-Marín, José Luis Llácer, Emanuele Panza

Publikováno v: Journal of Inherited Metabolic Disease. 43:657-670

The bifunctional homooligomeric enzyme Δ1 -pyrroline-5-carboxylate synthetase (P5CS) and its encoding gene ALDH18A1 were associated with disease in 1998. Two siblings who presented paradoxical hyperammonemia (alleviated by protein), mental disabilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94298741a5a780d4d7977223e1b0419e
https://doi.org/10.1002/jimd.12220

Correction: The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

Autor: José Luis Llácer

Publikováno v: PLOS Pathogens. 18:e1010995

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7c7cc7ad59709525bc505960d107931
https://doi.org/10.1371/journal.ppat.1010995

Infant hydrocephalus in sub-Saharan Africa: Impact of perioperative care in the Zanzibar archipelago

Autor: Luis Moreno Oliveras, José Luis Llácer Ortega, Andreas Leidinger, Mohamed Ali Haji, María Pilar Chisbert Genovés, José Piquer Belloch

Publikováno v: Neurocirugia
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

Introduction: Child hydrocephalus in low- and middle-income countries represents one of the most sensitive ethical and health problems facing international health development. The most optimistic estimates indicate that 200,000 newborns annually will

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efea3da6f9a50e3f348cf6b8473b8df
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=9237