1,5-Benzodiazepin-2(3H)-ones: In Vitro Evaluation as Antiparkinsonian Agents

Autor: Ana Ortíz de Zárate, Marta Pérez-Torralba, Iñigo Bonet Isidro, Concepción López, Rosa M. Claramunt, Diana Martínez-Casanova, Isabel Sánchez-Vera, Jesús Jiménez-González, José Luis Lavandera

Publikováno v: Antioxidants, Vol 10, Iss 10, p 1584 (2021)

A new series of twenty-three 1,5-benzodiazepin-2(3H)-ones were synthesized and evaluated in the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), ferric reducing antioxidant power (FRAP), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays

Externí odkaz: https://doaj.org/article/167ae08d798f40a3b39d0b31a3d60417

¿Hay diferencias en las calificaciones de Fisiología utilizando metodología presencial versus híbrida como consecuencia de la pandemia?

Autor: Esther Escudero, Ursula MuÑoz, María Cruz Sádaba, José Luis Lavandera, Isabel Sánchez-Vera

[EN] As consequence of the restrictions on attendance in classrooms due to the pandemic, teaching has been adapted to avoid the limitations imposed by the capacity. In the 20/21 academic year, we have implemented the Hyflex methodology in the class-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038e4da96d52aeb2b0581fcbffcf0e9e
https://hdl.handle.net/10251/191021

Evaluation of the Antioxidant and Neuroprotectant Activities of New Asymmetrical 1,3-Diketones

Autor: Dionisia Sanz, Diana Martínez Casanova, Rosa M. Claramunt, E. Escudero, María Carmen Torralba, José Luis Lavandera, María Pilar Cabildo, Yaiza Rebeca Sánchez-Alegre, María R. Torres, María Pilar Cornago, Carla I. Nieto

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
instname
Molecules
Volume 23
Issue 8
Molecules, Vol 23, Iss 8, p 1837 (2018)
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

A series of fourteen new asymmetrical 1,3-diketone derivatives have been synthesized and evaluated in the ABTS, FRAP and DPPH assays as a new chemotype with antioxidant and drug-like properties. All the compounds displayed low cytotoxicity in compari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8220dec5aca1e054033eabfb8bf3717f
https://eprints.ucm.es/id/eprint/66548/1/molecules-23-01837.pdf

Spectres de Masse FAB en Mode Positif de Cations Hétérocycliques Doublement Charges Apparentes au Dibenzo[a,e]Cyclooctane

Autor: Jean-Louis Aubagnac, José-Luis Lavandera, R. M. Claramunt, José Elguero

Publikováno v: Bulletin des Sociétés Chimiques Belges. 100:459-466

FAB mass spectra in positive mode of doubly charged heterocyclic cations allow identification of such structures. Furthermore, two characteristics of these spectra (low abundance of the doubly charged cations and the reduction phenomenon) are in agre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab50341c65d0fe07c9cd4f4abc443ae4
https://doi.org/10.1002/bscb.19911000605

Conformational analysis of heterocyclic analogues of 5,6,11,12-tetrahydrodibenzo[a,e]cyclooctene: 6,7,14,15-tetrahydrobisbenzimidazo[1,2-a:1′,2′-e][1,5]diazocine and 6,7,13,14-tetrahydrobispyrido[1,2-a:1′,2′-e]diazocinediium dibromide

Autor: Rosa Ma Claramunt, José Elguero, José-Luis Lavandera, María Luisa Jimeno, Dionisia Sanz

Publikováno v: Tetrahedron. 54:9569-9580

The 1H and 13C NMR spectra of the title compounds have been recorded. While the spectrum of 6,7,14,15-tetrahydrobisbenzimidazo[1,2-a:1′,2′-e][1,5]diazocine 3 does not show any dependence with the temperature in the studied range (−65 to +75 °C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::068d98f10c1f52f900b77d82200b2c13
https://doi.org/10.1016/s0040-4020(98)00516-x