Zobrazeno 1 - 10
of 21
pro vyhledávání: '"José Luis Gomez-Skarmeta"'
Autor:
Dave T. Gerrard, Andrew A. Berry, Rachel E. Jennings, Matthew J. Birket, Peyman Zarrineh, Myles G. Garstang, Sarah L. Withey, Patrick Short, Sandra Jiménez-Gancedo, Panos N. Firbas, Ian Donaldson, Andrew D. Sharrocks, Karen Piper Hanley, Matthew E. Hurles, José Luis Gomez-Skarmeta, Nicoletta Bobola, Neil A. Hanley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
How the epigenomic landscape linked to transcription regulates human embryonic development is unclear. Here, the authors analyse the dynamics of H3K27Ac, H3K4me3 and H3K27me3 during the period when organs first assemble as a platform for understandin
Externí odkaz:
https://doaj.org/article/a296a0ec6d0e434aa7dff480689080a7
Autor:
Xavier Grau-Bové, Lucie Subirana, Lydvina Meister, Anaël Soubigou, Ana Neto, Anamaria Elek, Silvia Naranjo, Oscar Fornas, Jose Luis Gomez-Skarmeta, Juan J. Tena, Manuel Irimia, Stéphanie Bertrand, Arnau Sebé-Pedrós, Hector Escriva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The emergence of new structures can often be linked to the evolution of novel cell types that follows the rewiring of developmental gene regulatory subnetworks. Vertebrates are characterized by a complex body plan compared to the other chord
Externí odkaz:
https://doaj.org/article/22d3055037d24ede9fd6eb9575c56c8f
Autor:
Eva D’haene, Víctor López-Soriano, Pedro Manuel Martínez-García, Soraya Kalayanamontri, Alfredo Dueñas Rey, Ana Sousa-Ortega, Silvia Naranjo, Stijn Van de Sompele, Lies Vantomme, Quinten Mahieu, Sarah Vergult, Ana Neto, José Luis Gómez-Skarmeta, Juan Ramón Martínez-Morales, Miriam Bauwens, Juan Jesús Tena, Elfride De Baere
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-24 (2024)
Abstract Background Vision depends on the interplay between photoreceptor cells of the neural retina and the underlying retinal pigment epithelium (RPE). Most genes involved in inherited retinal diseases display specific spatiotemporal expression wit
Externí odkaz:
https://doaj.org/article/a3d8d2ce3b6a449b865a48720cdd33d6
Autor:
Joaquín, Letelier, Javier, Terriente, Ivan, Belzunce, Adria, Voltes, Cristian Alberto, Undurraga, Rocio, Polvillo, Lucie, Devos, Juan J, Tena, Ignacio, Maeso, Sylvie, Retaux, José Luis, Gomez-Skarmeta, Juan R, Martínez-Morales, Cristina, Pujades
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(16)
Evolution of organismal complexity and species diversity depends on the emergence of novel gene functions. Nevertheless, evolution rarely produces novelties from scratch but works on the weak promiscuous preexisting activities or appears by genomic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c39f92250c72e12909b867e85e3bf08d
https://pubmed.ncbi.nlm.nih.gov/29610331
https://pubmed.ncbi.nlm.nih.gov/29610331
Autor:
Eudald Pascual-Carreras, Marta Marín-Barba, Sergio Castillo-Lara, Pablo Coronel-Córdoba, Marta Silvia Magri, Grant N. Wheeler, Jose Luis Gómez-Skarmeta, Josep F. Abril, Emili Saló, Teresa Adell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Any planarian fragment regenerates the missing head and tail in the proper end. Early activation of the Wnt/β-catenin signaling pathway changes the chromatin accessibility of the cells of the posterior-facing wound to regenerate a tail.
Externí odkaz:
https://doaj.org/article/4d696ab5163e4238a799db2d227455bc
Autor:
Renata Bordeira-Carriço, Joana Teixeira, Marta Duque, Mafalda Galhardo, Diogo Ribeiro, Rafael D. Acemel, Panos. N. Firbas, Juan J. Tena, Ana Eufrásio, Joana Marques, Fábio J. Ferreira, Telmo Freitas, Fátima Carneiro, José Luís Goméz-Skarmeta, José Bessa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Alterations in cis-regulatory elements (CREs) can contribute to pancreatic diseases. Here the authors combine chromatin profiling and interaction points with in vivo reporter assays in zebrafish to uncover functionally equivalent human CREs, helping
Externí odkaz:
https://doaj.org/article/1a526720f0e94a6eb3de65fc0179fea9
Autor:
Ivy Aneas, Donna C. Decker, Chanie L. Howard, Débora R. Sobreira, Noboru J. Sakabe, Kelly M. Blaine, Michelle M. Stein, Cara L. Hrusch, Lindsey E. Montefiori, Juan Tena, Kevin M. Magnaye, Selene M. Clay, James E. Gern, Daniel J. Jackson, Matthew C. Altman, Edward T. Naureckas, Douglas K. Hogarth, Steven R. White, Jose Luis Gomez-Skarmeta, Nathan Schoetler, Carole Ober, Anne I. Sperling, Marcelo A. Nóbrega
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Susceptibility to asthma and severity of symptoms are regulated by a number of different genomic regions. Here the authors characterise a 5kb regulatory region and demonstrate genetic and topological regulation of IL33 and association with disease in
Externí odkaz:
https://doaj.org/article/91de69f13ca849d4bde27470e200f0b0
Autor:
Raquel García-Pérez, Paula Esteller-Cucala, Glòria Mas, Irene Lobón, Valerio Di Carlo, Meritxell Riera, Martin Kuhlwilm, Arcadi Navarro, Antoine Blancher, Luciano Di Croce, José Luis Gómez-Skarmeta, David Juan, Tomàs Marquès-Bonet
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Comparative epigenomics has revealed principles underlying the evolution of gene expression regulation, and the integration of epigenomic data is important for a deeper understanding of this evolution. Here the authors report the evolutionary dynamic
Externí odkaz:
https://doaj.org/article/60968dc22fd449f3aebdf1675cc35a52
Autor:
Jessica Cheng, Joshua S. Clayton, Rafael D. Acemel, Ye Zheng, Rhonda L. Taylor, Sündüz Keleş, Martin Franke, Susan A. Boackle, John B. Harley, Elizabeth Quail, José Luis Gómez-Skarmeta, Daniela Ulgiati
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The Regulators of Complement Activation (RCA) gene cluster comprises several tandemly arranged genes with shared functions within the immune system. RCA members, such as complement receptor 2 (CR2), are well-established susceptibility genes in comple
Externí odkaz:
https://doaj.org/article/d05f0fbeee494a1ba5b7d2d49c8e5982
Autor:
Marta Silvia Magri, Sandra Jiménez-Gancedo, Stephanie Bertrand, Alicia Madgwick, Hector Escrivà, Patrick Lemaire, José Luis Gómez-Skarmeta
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
Cis-regulatory elements (CREs) are non-coding DNA regions involved in the spatio-temporal regulation of gene expression. Gene regulatory changes drive animal development and play major roles during evolution of animal body plans. Therefore, we believ
Externí odkaz:
https://doaj.org/article/dd2093d7f0d3497eae981451f131b25c