Zobrazeno 1 - 10
of 167
pro vyhledávání: '"José Luis Gómez-Skarmeta"'
Autor:
Eva D’haene, Víctor López-Soriano, Pedro Manuel Martínez-García, Soraya Kalayanamontri, Alfredo Dueñas Rey, Ana Sousa-Ortega, Silvia Naranjo, Stijn Van de Sompele, Lies Vantomme, Quinten Mahieu, Sarah Vergult, Ana Neto, José Luis Gómez-Skarmeta, Juan Ramón Martínez-Morales, Miriam Bauwens, Juan Jesús Tena, Elfride De Baere
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-24 (2024)
Abstract Background Vision depends on the interplay between photoreceptor cells of the neural retina and the underlying retinal pigment epithelium (RPE). Most genes involved in inherited retinal diseases display specific spatiotemporal expression wit
Externí odkaz:
https://doaj.org/article/a3d8d2ce3b6a449b865a48720cdd33d6
Autor:
Jessica Cheng, Joshua S. Clayton, Rafael D. Acemel, Ye Zheng, Rhonda L. Taylor, Sündüz Keleş, Martin Franke, Susan A. Boackle, John B. Harley, Elizabeth Quail, José Luis Gómez-Skarmeta, Daniela Ulgiati
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The Regulators of Complement Activation (RCA) gene cluster comprises several tandemly arranged genes with shared functions within the immune system. RCA members, such as complement receptor 2 (CR2), are well-established susceptibility genes in comple
Externí odkaz:
https://doaj.org/article/d05f0fbeee494a1ba5b7d2d49c8e5982
Autor:
Raquel García-Pérez, Paula Esteller-Cucala, Glòria Mas, Irene Lobón, Valerio Di Carlo, Meritxell Riera, Martin Kuhlwilm, Arcadi Navarro, Antoine Blancher, Luciano Di Croce, José Luis Gómez-Skarmeta, David Juan, Tomàs Marquès-Bonet
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Comparative epigenomics has revealed principles underlying the evolution of gene expression regulation, and the integration of epigenomic data is important for a deeper understanding of this evolution. Here the authors report the evolutionary dynamic
Externí odkaz:
https://doaj.org/article/60968dc22fd449f3aebdf1675cc35a52
Autor:
Marta Silvia Magri, Sandra Jiménez-Gancedo, Stephanie Bertrand, Alicia Madgwick, Hector Escrivà, Patrick Lemaire, José Luis Gómez-Skarmeta
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
Cis-regulatory elements (CREs) are non-coding DNA regions involved in the spatio-temporal regulation of gene expression. Gene regulatory changes drive animal development and play major roles during evolution of animal body plans. Therefore, we believ
Externí odkaz:
https://doaj.org/article/dd2093d7f0d3497eae981451f131b25c
Autor:
Sebastian Kittelmann, Alexandra D Buffry, Franziska A Franke, Isabel Almudi, Marianne Yoth, Gonzalo Sabaris, Juan Pablo Couso, Maria D S Nunes, Nicolás Frankel, José Luis Gómez-Skarmeta, Jose Pueyo-Marques, Saad Arif, Alistair P McGregor
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007375 (2018)
Convergent phenotypic evolution is often caused by recurrent changes at particular nodes in the underlying gene regulatory networks (GRNs). The genes at such evolutionary 'hotspots' are thought to maximally affect the phenotype with minimal pleiotrop
Externí odkaz:
https://doaj.org/article/1d2d9b4398814abc9a4ff215c13fb8f9
Autor:
Ibai Irastorza-Azcarate, Rafael D Acemel, Juan J Tena, Ignacio Maeso, José Luis Gómez-Skarmeta, Damien P Devos
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 3, p e1006030 (2018)
The use of 3C-based methods has revealed the importance of the 3D organization of the chromatin for key aspects of genome biology. However, the different caveats of the variants of 3C techniques have limited their scope and the range of scientific fi
Externí odkaz:
https://doaj.org/article/2d386507d10240e2831fe5465f72550f
Autor:
José Luis Royo, José Bessa, Carmen Hidalgo, Ana Fernández-Miñán, Juan J Tena, Yolanda Roncero, José Luis Gómez-Skarmeta, Fernando Casares
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33617 (2012)
Meis1, a conserved transcription factor of the TALE-homeodomain class, is expressed in a wide variety of tissues during development. Its complex expression pattern is likely to be controlled by an equally complex regulatory landscape. Here we have sc
Externí odkaz:
https://doaj.org/article/b6145c7b413a4e46a042545cccb87c54
Autor:
José Luis Royo, Carmen Hidalgo, Yolanda Roncero, María Angeles Seda, Altuna Akalin, Boris Lenhard, Fernando Casares, José Luis Gómez-Skarmeta
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24824 (2011)
Non-coding DNA conservation across species has been often used as a predictor for transcriptional enhancer activity. However, only a few systematic analyses of the function of these highly conserved non-coding regions (HCNRs) have been performed. Her
Externí odkaz:
https://doaj.org/article/cd2f980e59994b39a5d24e3a03e53520
Autor:
Àlex Robert-Moreno, Silvia Naranjo, Elisa de la Calle-Mustienes, José Luis Gómez-Skarmeta, Berta Alsina
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15907 (2010)
POU3F4 is a member of the POU-homedomain transcription factor family with a prominent role in inner ear development. Mutations in the human POU3F4 coding unit leads to X-linked deafness type 3 (DFN3), characterized by conductive hearing loss and prog
Externí odkaz:
https://doaj.org/article/ba2b51bd862c4bb492378cff64271950
Autor:
Alan M Pittman, Silvia Naranjo, Sanni E Jalava, Philip Twiss, Yussanne Ma, Bianca Olver, Amy Lloyd, Jayaram Vijayakrishnan, Mobshra Qureshi, Peter Broderick, Tom van Wezel, Hans Morreau, Sari Tuupanen, Lauri A Aaltonen, M Eva Alonso, Miguel Manzanares, Angela Gavilán, Tapio Visakorpi, José Luis Gómez-Skarmeta, Richard S Houlston
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001126 (2010)
Common genetic variation at human 8q23.3 is significantly associated with colorectal cancer (CRC) risk. To elucidate the basis of this association we compared the frequency of common variants at 8q23.3 in 1,964 CRC cases and 2,081 healthy controls. R
Externí odkaz:
https://doaj.org/article/76ea75af14214caa92660695b7398130