Zobrazeno 1 - 10
of 66
pro vyhledávání: '"José Luis, Bocco"'
Autor:
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/c96b11721b9b47a1ac2f8d97e71e0b1f
Autor:
Yanina Luciana Mazzocco, Gastón Bergero, Sebastian Del Rosso, Natalia Eberhardt, Claudia Sola, Héctor Alex Saka, Sofía María Villada, José Luis Bocco, Maria Pilar Aoki
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionWe have acquired significant knowledge regarding the pathogenesis of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2). However, the underlying mechanisms responsible for disease recovery still need to be fully unders
Externí odkaz:
https://doaj.org/article/0bb72ea6c552461c94d0e48ad4d0e6f9
Autor:
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife, Vol 12 (2023)
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-de
Externí odkaz:
https://doaj.org/article/8d32f189375347eda9d14d8aef197263
Autor:
Andrés Marcos Castellaro, Pablo Velez, Guillermo Giaj Merlera, Juan Rondan Dueñas, Felix Condat, Jesica Gallardo, Aylen Makhoul, Camila Cinalli, Lorenzo Rosales Cavaglieri, Guadalupe Di Cola, Paola Sicilia, Laura López, Facultad de Ciencias Químicas UNC Group, José Luis Bocco, María Gabriela Barbás, Diego Hernán Cardozo, María Belén Pisano, Viviana Ré, Andrea Belaus, Gonzalo Castro
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266408 (2022)
BackgroundThe current COVID-19 pandemic has overloaded the diagnostic capacity of laboratories by the gold standard method rRT-PCR. This disease has a high spread rate and almost a quarter of infected individuals never develop symptoms. In this scena
Externí odkaz:
https://doaj.org/article/3efb9ef917b14f3498ffac2eb01635d0
Autor:
María Candelaria Llorens, Fabiana Alejandra Rossi, Iris Alejandra García, Mariana Cooke, Martin C. Abba, Cynthia Lopez-Haber, Laura Barrio-Real, María Victoria Vaglienti, Mario Rossi, José Luis Bocco, Marcelo G. Kazanietz, Gastón Soria
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
ZEB1 is a master regulator of the Epithelial-to-Mesenchymal Transition (EMT) program. While extensive evidence confirmed the importance of ZEB1 as an EMT transcription factor that promotes tumor invasiveness and metastasis, little is known about its
Externí odkaz:
https://doaj.org/article/ea4079824ca24cf1999973aeca05bf3b
Autor:
Sebastián Omar Siri, Julieta Martino, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife. 12
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-de
Autor:
Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa
Extended methods including bionformatic analysis details and scripts used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7401f8870e3db6340d26799120661173
https://doi.org/10.1158/1078-0432.22472205
https://doi.org/10.1158/1078-0432.22472205
Autor:
Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa
Legends included in the figure file
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a26ecc52181f0eb97f308f30e83b607
https://doi.org/10.1158/1078-0432.22472220.v1
https://doi.org/10.1158/1078-0432.22472220.v1
Autor:
Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa
Purpose:BRCA1 and BRCA2 deficiencies are widespread drivers of human cancers that await the development of targeted therapies. We aimed to identify novel synthetic lethal relationships with therapeutic potential using BRCA-deficient isogenic backgrou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34135ca0a46fae703101f62ea39fe83c
https://doi.org/10.1158/1078-0432.c.6528156.v1
https://doi.org/10.1158/1078-0432.c.6528156.v1
Autor:
Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa
Full list of hits of the BRCA1-deficient population in the screening performed with the PKIS2 library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0056d2d9059527e3232a57cd78b0f096
https://doi.org/10.1158/1078-0432.22472202
https://doi.org/10.1158/1078-0432.22472202