Zobrazeno 1 - 9
of 9
pro vyhledávání: '"José Luís Bocco"'
Autor:
Iris A. García, Maria Florencia Pansa, Adriana Del Valle Pacciaroni, Manuela E. García, Maria Laura Gonzalez, Juan Carlos Oberti, José Luís Bocco, Maria Cecilia Carpinella, Gloria E. Barboza, Viviana E. Nicotra, Gastón Soria
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Several plants from South America show strong antitumoral properties based on anti-proliferative and/or pro-apoptotic activities. In this work we aimed to identify selective cytotoxic compounds that target BRCA1-deficient cancer cells by Synthetic Le
Externí odkaz:
https://doaj.org/article/0ce6284b1bf7492eb3faf577a23a41b9
Autor:
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/c96b11721b9b47a1ac2f8d97e71e0b1f
Autor:
Yanina Luciana Mazzocco, Gastón Bergero, Sebastian Del Rosso, Natalia Eberhardt, Claudia Sola, Héctor Alex Saka, Sofía María Villada, José Luis Bocco, Maria Pilar Aoki
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionWe have acquired significant knowledge regarding the pathogenesis of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2). However, the underlying mechanisms responsible for disease recovery still need to be fully unders
Externí odkaz:
https://doaj.org/article/0bb72ea6c552461c94d0e48ad4d0e6f9
Autor:
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife, Vol 12 (2023)
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-de
Externí odkaz:
https://doaj.org/article/8d32f189375347eda9d14d8aef197263
Autor:
Andrés Marcos Castellaro, Pablo Velez, Guillermo Giaj Merlera, Juan Rondan Dueñas, Felix Condat, Jesica Gallardo, Aylen Makhoul, Camila Cinalli, Lorenzo Rosales Cavaglieri, Guadalupe Di Cola, Paola Sicilia, Laura López, Facultad de Ciencias Químicas UNC Group, José Luis Bocco, María Gabriela Barbás, Diego Hernán Cardozo, María Belén Pisano, Viviana Ré, Andrea Belaus, Gonzalo Castro
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266408 (2022)
BackgroundThe current COVID-19 pandemic has overloaded the diagnostic capacity of laboratories by the gold standard method rRT-PCR. This disease has a high spread rate and almost a quarter of infected individuals never develop symptoms. In this scena
Externí odkaz:
https://doaj.org/article/3efb9ef917b14f3498ffac2eb01635d0
Autor:
María Candelaria Llorens, Fabiana Alejandra Rossi, Iris Alejandra García, Mariana Cooke, Martin C. Abba, Cynthia Lopez-Haber, Laura Barrio-Real, María Victoria Vaglienti, Mario Rossi, José Luis Bocco, Marcelo G. Kazanietz, Gastón Soria
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
ZEB1 is a master regulator of the Epithelial-to-Mesenchymal Transition (EMT) program. While extensive evidence confirmed the importance of ZEB1 as an EMT transcription factor that promotes tumor invasiveness and metastasis, little is known about its
Externí odkaz:
https://doaj.org/article/ea4079824ca24cf1999973aeca05bf3b
Autor:
Maria Eugenia Sabatino, Andrés Castellaro, Ana C. Racca, Sofía Carbajosa González, Maria Florencia Pansa, Gastón Soria, Jose Luis Bocco
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Krüppel-like factor 6 (KLF6) is a transcription factor involved in the regulation of several cellular processes. Regarding its role in tumorigenesis, KLF6 is considered a tumor suppressor. Numerous reports demonstrate its frequent genomic loss or do
Externí odkaz:
https://doaj.org/article/f88210b449a348e6978d7bb003bfd45e
Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma.
Autor:
Lucas Daniel Trucco, Emiliano Roselli, Paula Araya, Nicolás Gonzalo Nuñez, Hebe Agustina Mena, José Luis Bocco, Soledad Negrotto, Mariana Maccioni
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179897 (2017)
The mechanisms that link inflammatory responses to cancer development remain a subject of intense investigation, emphasizing the need to better understand the cellular and molecular pathways that create a tumor promoting microenvironment. The myeloid
Externí odkaz:
https://doaj.org/article/7e9bf6cebb804386ae8b497ffb48e716
Autor:
María Belén Federico, María Belén Vallerga, Analía Radl, Natalia Soledad Paviolo, José Luis Bocco, Marina Di Giorgio, Gastón Soria, Vanesa Gottifredi
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005792 (2016)
Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fo
Externí odkaz:
https://doaj.org/article/61e0fe2d0bff468e85c226b73c4819ea