Zobrazeno 1 - 10
of 22
pro vyhledávání: '"José L Oliveira"'
Autor:
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál
Publikováno v:
PLoS Biology, Vol 15, Iss 6, p e1002607 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.2000644.].
Externí odkaz:
https://doaj.org/article/bae5ab0467af40af8e6103f70de1b9ab
Autor:
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál
Publikováno v:
PLoS Biology, Vol 15, Iss 5, p e2000644 (2017)
Genetically identical cells frequently display substantial heterogeneity in gene expression, cellular morphology and physiology. It has been suggested that by rapidly generating a subpopulation with novel phenotypic traits, phenotypic heterogeneity (
Externí odkaz:
https://doaj.org/article/8aa0f60a3d4b4da2b53a6c14ac85d68f
Autor:
Gabriela R Moura, Miguel Pinheiro, Adelaide Freitas, José L Oliveira, Jörg C Frommlet, Laura Carreto, Ana R Soares, Ana R Bezerra, Manuel A S Santos
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145593 (2015)
Externí odkaz:
https://doaj.org/article/6fa0225e6a6f47e189e1438db1333b1f
Autor:
Anna Bauer-Mehren, Erik M van Mullingen, Paul Avillach, María Del Carmen Carrascosa, Ricard Garcia-Serna, Janet Piñero, Bharat Singh, Pedro Lopes, José L Oliveira, Gayo Diallo, Ernst Ahlberg Helgee, Scott Boyer, Jordi Mestres, Ferran Sanz, Jan A Kors, Laura I Furlong
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 4, p e1002457 (2012)
Drug safety issues pose serious health threats to the population and constitute a major cause of mortality worldwide. Due to the prominent implications to both public health and the pharmaceutical industry, it is of great importance to unravel the mo
Externí odkaz:
https://doaj.org/article/6aef5971954d4f0a87e9cc952554fe7b
Autor:
Gabriela R Moura, Miguel Pinheiro, Adelaide Freitas, José L Oliveira, Jörg C Frommlet, Laura Carreto, Ana R Soares, Ana R Bezerra, Manuel A S Santos
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26817 (2011)
Codon pair usage (codon context) is a species specific gene primary structure feature whose evolutionary and functional roles are poorly understood. The data available show that codon-context has direct impact on both translation accuracy and efficie
Externí odkaz:
https://doaj.org/article/bcb69cd0ed29424e81502889e6223b70
Autor:
Gabriela Moura, Miguel Pinheiro, Joel Arrais, Ana Cristina Gomes, Laura Carreto, Adelaide Freitas, José L Oliveira, Manuel A S Santos
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e847 (2007)
BACKGROUND: Codon usage and codon-pair context are important gene primary structure features that influence mRNA decoding fidelity. In order to identify general rules that shape codon-pair context and minimize mRNA decoding error, we have carried out
Externí odkaz:
https://doaj.org/article/01c10da5a75245a682d996c3320cf377
Autor:
Maryam Abbasi, Beatriz P. Santos, Tiago C. Pereira, Raul Sofia, Nelson R. C. Monteiro, Carlos J. V. Simões, Rui Brito, Bernardete Ribeiro, José L. Oliveira, Joel P. Arrais
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Drug design is an important area of study for pharmaceutical businesses. However, low efficacy, off-target delivery, time consumption, and high cost are challenges and can create barriers that impact this process. Deep Learning models are em
Externí odkaz:
https://doaj.org/article/7198e0181ce94996b3f69a3a3350a466
Publikováno v:
Caring is Sharing – Exploiting the Value in Data for Health and Innovation ISBN: 9781643683881
Genomics has significantly impacted the field of medicine, with advances in DNA sequencing leading to personalized medicine and a deeper understanding of the genomic basis of various diseases. The ability to share genomic data is crucial for advancin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6019e334cb03aec33c36e055d06f0b07
https://doi.org/10.3233/shti230350
https://doi.org/10.3233/shti230350
Autor:
Maryam Abbasi, Beatriz P. Santos, Tiago C. Pereira, Raul Sofa, Nelson R. C. Monteiro, Carlos J. V. Simões, Rui M. M. Brito, Bernardete Ribeiro, José L. Oliveira, Joel P. Arrais
Publikováno v:
Journal of Cheminformatics. 14
Publikováno v:
Computers in biology and medicine. 147
The accurate identification of Drug-Target Interactions (DTIs) remains a critical turning point in drug discovery and understanding of the binding process. Despite recent advances in computational solutions to overcome the challenges of in vitro and