Zobrazeno 1 - 10
of 238
pro vyhledávání: '"José López-Barneo"'
Autor:
Alejandro Moreno-Domínguez, Olalla Colinas, Ignacio Arias-Mayenco, José M. Cabeza, Juan L. López-Ogayar, Navdeep S. Chandel, Norbert Weissmann, Natascha Sommer, Alberto Pascual, José López-Barneo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Vasodilation in response to low oxygen (O2) tension (hypoxic vasodilation) is an essential homeostatic response of systemic arteries that facilitates O2 supply to tissues according to demand. However, how blood vessels react to O2 deficiency
Externí odkaz:
https://doaj.org/article/9e9c2aebd1f5453c9d2c8b4b2a2bbe68
Autor:
Blanca Jiménez-Gómez, Patricia Ortega-Sáenz, Lin Gao, Patricia González-Rodríguez, Paula García-Flores, Navdeep Chandel, José López-Barneo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Activation of breathing during hypoxia is abolished in mice lacking mitochondrial complex I in carotid body chemoreceptors, however the specific contribution of mitochondrial complex I to this process is unclear. Here, the authors show that recovery
Externí odkaz:
https://doaj.org/article/c9432bcd2efa48e48202eb9116a93bde
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
An adequate supply of oxygen (O2) is essential for most life forms on earth, making the delivery of appropriate levels of O2 to tissues a fundamental physiological challenge. When O2 levels in the alveoli and/or blood are low, compensatory adaptive r
Externí odkaz:
https://doaj.org/article/4feae3ec74e7488fa6a89e9ec83aef00
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Lactate levels in blood change during hypoxia or exercise, however whether this variable is sensed to evoke adaptive responses is unknown. Here the authors show that oxygen-sensing carotid body cells stimulated by hypoxia are also activated by lactat
Externí odkaz:
https://doaj.org/article/337a29a5be2d461eb8785176a46319bd
Autor:
Javier Villadiego, Ana B. Muñoz-Manchado, Verónica Sobrino, Victoria Bonilla-Henao, Nela Suárez-Luna, Patricia Ortega-Sáenz, Ricardo Pardal, José López-Barneo, Juan J. Toledo-Aral
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5575 (2023)
Antiparkinsonian carotid body (CB) cell therapy has been proven to be effective in rodent and nonhuman primate models of Parkinson’s disease (PD), exerting trophic protection and restoration of the dopaminergic nigrostriatal pathway. These neurotro
Externí odkaz:
https://doaj.org/article/3449550320e44403a6f0c31d50244dfb
Autor:
Yasumasa Okada, Julian F. R. Paton, José López-Barneo, Richard J. A. Wilson, Nephtali Marina, Mieczyslaw Pokorski
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/3a592b4107d948678258180c45b61263
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100535- (2021)
Summary: Reactive oxygen species (ROS) are important signaling molecules for physiologic processes such as acute response to hypoxia. However, reliable real-time ROS measurement in cells has been a long-standing methodological challenge. Here, we pre
Externí odkaz:
https://doaj.org/article/19197bd2ef5049bc970974d2b14c4e1f
Autor:
José López-Barneo, M. Celeste Simon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-3 (2020)
Understanding the cellular adaptation to oxygen deficiency -hypoxia- has a profound impact on our knowledge of the pathogenesis of several diseases. The elucidation of the molecular machinery that regulates response to hypoxia has been awarded the No
Externí odkaz:
https://doaj.org/article/c5f03d8b917f4469b35d8db6522072b0
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical and chemical parameters in the blood. These cells are also essential for O2 homeostasis. Glomus cells are prototypical peripheral
Externí odkaz:
https://doaj.org/article/9bad6bb655ee4783b192266ca7f2f1d8
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 908-915 (2017)
Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O2-sensitive glomus cells with O2-regulated ion channels. Upon exposu
Externí odkaz:
https://doaj.org/article/9d0e12eaa42241e7b7f6fe6a98cc97f0