Zobrazeno 1 - 10
of 12
pro vyhledávání: '"José Ignacio Saldaña"'
Autor:
Alessandro Barbarulo, Ching-In Lau, Konstantinos Mengrelis, Susan Ross, Anisha Solanki, José Ignacio Saldaña, Tessa Crompton
Publikováno v:
Journal of Developmental Biology, Vol 4, Iss 3, p 22 (2016)
T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here w
Externí odkaz:
https://doaj.org/article/58d27381842e4da681b6a1ac26fd7260
Autor:
Ching-In, Lau, Diana C, Yánez, Anisha, Solanki, Eleftheria, Papaioannou, José Ignacio, Saldaña, Tessa, Crompton
Publikováno v:
Journal of Autoimmunity
The Foxa1 and Foxa2 transcription factors are essential for mouse development. Here we show that they are expressed in thymic epithelial cells (TEC) where they regulate TEC development and function, with important consequences for T-cell development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5d08b349af113c952b6cab8d000c802
https://pubmed.ncbi.nlm.nih.gov/30061015
https://pubmed.ncbi.nlm.nih.gov/30061015
Autor:
Anna L. Furmanski, José Ignacio Saldaña, Michael P. Blundell, Adrian J. Thrasher, Ryan F.L. O'Shaughnessy, Neil J. Sebire, Tessa Crompton, E. Graham Davies
Publikováno v:
The Journal of Investigative Dermatology
Here we present a mouse model for T-cell targeting of hair follicles, linking the pathogenesis of alopecia to that of depigmentation disorders. Clinically, thymus transplantation has been successfully used to treat T-cell immunodeficiency in congenit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa6c3dc72f92bf7ba4983a888cc0a3b
https://doi.org/10.1038/jid.2012.492
https://doi.org/10.1038/jid.2012.492
Autor:
Ching-In, Lau, Alessandro, Barbarulo, Anisha, Solanki, José Ignacio, Saldaña, Tessa, Crompton
Publikováno v:
Oncotarget
Kif7 is a ciliary kinesin motor protein that regulates mammalian Hedgehog pathway activation through influencing structure of the primary cilium. Here we show that Kif7 is required for normal T-cell development, despite the fact that T-cells lack pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43ba807416fb39dd62bbf2fe4033ec9b
https://pubmed.ncbi.nlm.nih.gov/28445929
https://pubmed.ncbi.nlm.nih.gov/28445929
Publikováno v:
The Journal of Experimental Medicine
Solanki et al. show that stromal activity of the transcription factor Gli3 is required for B cell development in the fetal liver. Gli3 functions to repress Shh expression, and Shh signals to developing B cells to regulate their development at multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::863f760178c4bc4175944c30d34e8c75
https://pubmed.ncbi.nlm.nih.gov/28533268
https://pubmed.ncbi.nlm.nih.gov/28533268
Autor:
Anna L. Furmanski, Susan V. Outram, José Ignacio Saldaña, Ching-In Lau, Tessa Crompton, Johannes T. Dessens
Publikováno v:
Blood. 119:4741-4751
The function of Hedgehog signaling in hematopoiesis is controversial, with different experimental systems giving opposing results. Here we examined the role of Desert Hedgehog (Dhh) in the regulation of murine erythropoiesis. Dhh is one of 3 mammalia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8ff109532be45e1124c7d2d560afc2
https://doi.org/10.1182/blood-2011-10-387266
https://doi.org/10.1182/blood-2011-10-387266
Autor:
Tessa Crompton, José Ignacio Saldaña, Susan Ross, Ekati Drakopoulou, Susan V. Outram, Nicola J. Rowbotham, Ariadne L. Hager-Theodorides, Anna L. Furmanski
Publikováno v:
Cell Cycle. 9:4144-4152
The Hedgehog (Hh) signaling pathway influences multiple stages of murine T-cell development. Hh signaling mediates transcriptional changes by the activity of the Gli family of transcription factors, Gli1, Gli2 and Gli3. Both Gli2 and Gli3 are essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bd10761f345e12c9e01b90012cf357
https://doi.org/10.4161/cc.9.20.13453
https://doi.org/10.4161/cc.9.20.13453
Autor:
John Goulding, Robert J. Snelgrove, Emily Gwyer, Arnaud Didierlaurent, Mary M. Cavanagh, Jeremy Wales, Erika Wissinger, José Ignacio Saldaña, Tracy Hussell
Publikováno v:
Proceedings of the American Thoracic Society. 4:618-625
Although the outcome of respiratory infection alters with age, nutritional status, and immunologic competence, there is a growing body of evidence that we all develop a unique but subtle inflammatory profile. This uniqueness is determined by the sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e115a294d509b67e8086448cfe6061
https://doi.org/10.1513/pats.200706-066th
https://doi.org/10.1513/pats.200706-066th
Autor:
Hemant, Sahni, Susan, Ross, Alessandro, Barbarulo, Anisha, Solanki, Ching-In, Lau, Anna, Furmanski, José Ignacio, Saldaña, Masahiro, Ono, Mike, Hubank, Martino, Barenco, Tessa, Crompton
Publikováno v:
Oncotarget
Developing thymocytes require pre-TCR signalling to differentiate from CD4−CD8− double negative to CD4+CD8+ double positive cell. Here we followed the transcriptional response to pre-TCR signalling in a synchronised population of differentiating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ada265e396371b6d8e698cbdb832c517
https://pubmed.ncbi.nlm.nih.gov/26415229
https://pubmed.ncbi.nlm.nih.gov/26415229
Autor:
Nikolaos Paschalidis, Fulvio D'Acquisto, Hemant Sahni, Anna L. Furmanski, Masahiro Ono, Tessa Crompton, José Ignacio Saldaña
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 190(6)
Genome-wide association studies of complex immune-mediated diseases have indicated that many genetic factors, each with individual low risk, contribute to overall disease. It is therefore timely and important to characterize how immune responses may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f30145b9ea58b3484667f656f888a8
https://pubmed.ncbi.nlm.nih.gov/23408837
https://pubmed.ncbi.nlm.nih.gov/23408837