Zobrazeno 1 - 10
of 53
pro vyhledávání: '"José Hurst"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract One common aspect in the pathology of many retinal diseases like age-related macular degeneration (AMD) is the death of retinal pigment epithelium (RPE) cells. RPE cells are essential for photoreceptor survival as they recycle and remove com
Externí odkaz:
https://doaj.org/article/532030cfc2254af3820c3dc569e6b6a7
Blue Light Damage and p53: Unravelling the Role of p53 in Oxidative-Stress-Induced Retinal Apoptosis
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2072 (2023)
In the digital age, the widespread presence of electronic devices has exposed humans to an exceptional amount of blue light (BL) emitted from screens, LEDs, and other sources. Studies have shown that prolonged exposure to BL could have harmful effect
Externí odkaz:
https://doaj.org/article/d3d7e4a34e484ce3b7989acad65e34cb
Autor:
José Hurst, Sven Schnichels
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/accc78f32ecc4d9ea2175eb7f7f5d003
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The protein p53 is the main human tumor suppressor. Since its discovery, extensive research has been conducted, which led to the general assumption that the purview of p53 is also essential for additional functions, apart from the prevention of carci
Externí odkaz:
https://doaj.org/article/feb65648c648440e8c83c96361057bdc
Autor:
Alice Rocha Teixeira Netto, Marc Dieter Hrusa, Karl-Ulrich Bartz-Schmidt, Sven Schnichels, José Hurst
Publikováno v:
Methods and Protocols, Vol 6, Iss 3, p 50 (2023)
In ophthalmic research, there is a strong need for in vitro corneal cell models. Here, we describe different protocols for the cultivation of primary corneal cells that were isolated from porcine eyes. This primary cell culture can be used to test ne
Externí odkaz:
https://doaj.org/article/3f1ce70909c14bdfb97673368acb8dbc
Autor:
Sven Schnichels, David Simmang, Marina Löscher, Andreas Herrmann, Jan Willem de Vries, Martin S. Spitzer, José Hurst
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 532 (2023)
Retinal eye diseases are the leading cause of blindness in the Western world. Up to date, the only efficient treatment for many retinal diseases consists of invasive intravitreal injections of highly concentrated drugs. Despite the fact that these in
Externí odkaz:
https://doaj.org/article/b767bbd8b6b744e69d920dcf31efd830
Autor:
Natalie Wagner, Armin Safaei, José Hurst, Pia A. Vogt, H. Burkhard Dick, Stephanie C. Joachim, Sven Schnichels
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 990 (2022)
The pathological events of age-related macular degeneration are characterized by degenerative processes involving the photoreceptor cells, retinal pigment epithelium (RPE), and the Bruch’s membrane as well as choroidal alterations. To mimic in vivo
Externí odkaz:
https://doaj.org/article/2f421dac845d40dca794cc3d006ef47f
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
The successful development of novel therapies is closely linked with understanding the underlying pathomechanisms of a disease. To do so, model systems that reflect human diseases and allow for the evaluation of new therapeutic approaches are needed.
Externí odkaz:
https://doaj.org/article/3ea910a89cd6448aa00519e4c685d448
Autor:
Natalie Wagner, Sabrina Reinehr, Maurice R. Gammel, Andrea Greulich, José Hurst, H. Burkhard Dick, Sven Schnichels, Stephanie C. Joachim
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Age-related macular degeneration (AMD) is the leading cause of blindness in industrialized countries among people over 60 years. It has multiple triggers and risk factors, but despite intense research efforts, its pathomechanisms are currently not co
Externí odkaz:
https://doaj.org/article/4764779f2bc54f1a8fd4a51293ef5923
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 134 (2022)
Topical drug delivery to the posterior segment of the eye is a very complex challenge. However, topical delivery is highly desired, to achieve an easy-to-use treatment option for retinal diseases. In this review, we focus on the drug characteristics
Externí odkaz:
https://doaj.org/article/c307b398f0b14ebf89c7ba9358d6a29d