Zobrazeno 1 - 10
of 58
pro vyhledávání: '"José G. Pichel"'
Autor:
Patricia Pérez-Matute, Icíar P. López, María Íñiguez, Emma Recio-Fernández, Raquel Torrens, Sergio Piñeiro-Hermida, Elvira Alfaro-Arnedo, Luong Chau, Christina Walz, Andreas Hoeflich, José A. Oteo, José G. Pichel
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
ObjectiveWe aimed to investigate the short and long-term metabolic consequences of IGF1R systemic gene deficiency in mice.MethodsUBC-CreERT2, Igf1rfl/fl mutant mice were used to suppress IGF1R signaling in adult tissues by inducing postnatal generali
Externí odkaz:
https://doaj.org/article/d487c97cd50643339ffa6225129c7e2c
Autor:
Elvira Alfaro-Arnedo, Icíar P. López, Sergio Piñeiro-Hermida, Álvaro C. Ucero, Francisco J. González-Barcala, Francisco J. Salgado, José G. Pichel
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 733 (2022)
In the original article [...]
Externí odkaz:
https://doaj.org/article/69a94a3ae23a4e8cb2a0229ed47bc2b4
Autor:
Elvira Alfaro-Arnedo, Icíar P. López, Sergio Piñeiro-Hermida, Álvaro C. Ucero, Francisco J. González-Barcala, Francisco J. Salgado, José G. Pichel
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 912 (2021)
Background: Asthma is a chronic lung disease characterized by reversible airflow obstruction, airway hyperresponsiveness (AHR), mucus overproduction and inflammation. Although Insulin-like growth factor 1 receptor (IGF1R) was found to be involved in
Externí odkaz:
https://doaj.org/article/6f9f70010fbb421d90ef8f772e6d3392
Autor:
Sergio Piñeiro-Hermida, Icíar P. López, Elvira Alfaro-Arnedo, Raquel Torrens, María Iñiguez, Lydia Alvarez-Erviti, Carlos Ruíz-Martínez, José G. Pichel
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract IGF1R (Insulin-like Growth Factor 1 Receptor) is a tyrosine kinase with pleiotropic cellular functions. IGF activity maintains human lung homeostasis and is implicated in pulmonary diseases such as cancer, ARDS, COPD, asthma and fibrosis. He
Externí odkaz:
https://doaj.org/article/3b2793cee94e4995ba43123296da8895
Publikováno v:
Biomedicines, Vol 9, Iss 2, p 158 (2021)
Insulin-like growth factor 1 receptor (IGF1R)-mediated signaling pathways modulate important neurophysiological aspects in the central nervous system, including neurogenesis, synaptic plasticity and complex cognitive functions. In the present study,
Externí odkaz:
https://doaj.org/article/84a1c691874c4ff0adbca7b20d893917
Autor:
Gonzalo Millán, Mattia Nieddu, Icíar P. López, Cintia Ezquerro, Jesús R. Berenguer, Ignacio M. Larráyoz, José G. Pichel, Elena Lalinde
Publikováno v:
Dalton Transactions. 52:6360-6374
A new family of luminescent cyclometalated Ir(iii) complexes [Ir(C^N)2(N^N)]+ was prepared. The most cytotoxic complex 2a-Cl locates in lysosomes but acts destroying mitochondria, while 3a-PF6 revelled its potential as photosensitiser in PDT.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8ee9e2b56055dec9a8d55e0e936af8a
https://doi.org/10.1039/d3dt00028a
https://doi.org/10.1039/d3dt00028a
Autor:
Elvira Alfaro-Arnedo, Icíar P. López, Sergio Piñeiro-Hermida, Marta Canalejo, Carolina Gotera, Jesús Javier Sola, Alejandra Roncero, Germán Peces-Barba, Carlos Ruíz-Martínez, José G. Pichel
Publikováno v:
Oncogene. 41:3625-3639
Given the long-term ineffectiveness of current therapies and late-stage diagnoses, lung cancer is a leading cause of malignant diseases. Tumor progression is influenced by cancer cell interactions with the tumor microenvironment (TME). Insulin-like g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5411a0a79b7c9b83837e44f23f45af97
https://doi.org/10.1038/s41388-022-02376-w
https://doi.org/10.1038/s41388-022-02376-w
Autor:
Laura Fernández-Blanco, Maria J. Calzada, Sandra Pérez-Rial, David Labrousse-Arias, Javier Sevilla-Montero, Icíar P. López, José G. Pichel, Gema Mondejar-Parreño, Germán Peces-Barba, Angel Cogolludo, Bianca Barreira, Elvira Alfaro-Arnedo, Victor I. Peinado, Cintia Fernández-Pérez
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Cigarette smoke is considered the chief leading cause of chronic obstructive pulmonary disease (COPD). Its impact on the progressive deterioration of airways has been extensively studied...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654600b15a4e4a6a21ed59b72f9b00c7
https://doi.org/10.1164/rccm.201911-2238oc
https://doi.org/10.1164/rccm.201911-2238oc
Autor:
G. Millán, M. Nieddu, C. Ezquerro, J. R. Berenguer, E. Lalinde, I. P. Lopez, I. M. Larráyoz, José G. Pichel
Nowadays, the desire to find new compounds with multifunctional properties, whose purpose is helping in the early diagnosis and treatment of some illness, has opened numerous investigations. In particular, in cancer treatments, the research of new th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10175::8fe8d8e6c9927ac0a30041f6dcbfeeac
https://investigacion.unirioja.es/documentos/641b0418124b445f6ae671e7
https://investigacion.unirioja.es/documentos/641b0418124b445f6ae671e7
Autor:
Carolina Gotera, Alejandra Roncero, Andreas Hoeflich, Christine Höflich, Elvira Alfaro-Arnedo, Germán Peces Barba, Iciar Paula Lopez Garcia, José G. Pichel, Alfredo Urtubia, Carlos Ruíz-Martínez, Marta Canalejo
Publikováno v:
Monitoring airway disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e21131ce8c193d2f54357406d8b032e
https://doi.org/10.1183/13993003.congress-2021.pa1952
https://doi.org/10.1183/13993003.congress-2021.pa1952