Zobrazeno 1 - 10
of 210
pro vyhledávání: '"José G Fernández-Bolaños"'
Autor:
I. Caroline Vaaland, Óscar López, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 349-360 (2023)
The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing a tacrine residue and a 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) or 1,4-dideoxy-1,4-imino-L-arabinitol (LAB) moiety held togeth
Externí odkaz:
https://doaj.org/article/d1237b9cbbfb410ca4a715968aec2873
Autor:
Tereza Hofmanova, Carolina Marques, Alfonso T. García-Sosa, Óscar López, Luisa Leitzbach, Elisabete P. Carreiro, Aday González-Bakker, Adrián Puerta, Holger Stark, José M. Padrón, José G. Fernández-Bolaños, Anthony J. Burke
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 101032- (2023)
The oxindole core is an important structural motif in many natural and synthetic substances with various biological activities including anticancer, antineurodegenerative, and antimicrobial properties. This report focuses on the synthesis and biologi
Externí odkaz:
https://doaj.org/article/75d359ef21d247a498f7e6bdb867b7b7
Autor:
Alexandra Ibáñez-Escribano, Cristina Fonseca-Berzal, Mónica Martínez-Montiel, Manuel Álvarez-Márquez, María Gómez-Núñez, Manuel Lacueva-Arnedo, Teresa Espinosa-Buitrago, Tania Martín-Pérez, José Antonio Escario, Penélope Merino-Montiel, Sara Montiel-Smith, Alicia Gómez-Barrio, Óscar López, José G. Fernández-Bolaños
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 781-791 (2022)
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evalu
Externí odkaz:
https://doaj.org/article/2e3a62e95f4841cdadefb7f108d1beea
Autor:
Tereza Cristina Santos Evangelista, Óscar López, Adrián Puerta, Miguel X. Fernandes, Sabrina Baptista Ferreira, José M. Padrón, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2395-2402 (2022)
The synthesis of four heterodimers in which the copper(I)-catalysed azide-alkyne cycloaddition was employed to connect a 1-deoxynojirimycin moiety with a benzotriazole scaffold is reported. The heterodimers were investigated as inhibitors against ace
Externí odkaz:
https://doaj.org/article/ab088dcc1fde417ebcc32bdfc2fb0a36
Autor:
Emanuela Berrino, Simone Carradori, Fabrizio Carta, Francesco Melfi, Marialucia Gallorini, Giulio Poli, Tiziano Tuccinardi, José G. Fernández-Bolaños, Óscar López, Jacobus P. Petzer, Anél Petzer, Paolo Guglielmi, Daniela Secci, Claudiu T. Supuran
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2044 (2023)
Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial etiology. The most common NDs are Alzheimer’s disease and Parkinson’s disease, in which cholinergic and dopaminergic sys
Externí odkaz:
https://doaj.org/article/b5a1744f71ab47be8afc72bbec67ca7a
Autor:
Alma Fuentes-Aguilar, Penélope Merino-Montiel, Sara Montiel-Smith, Socorro Meza-Reyes, José Luis Vega-Báez, Adrián Puerta, Miguel X. Fernandes, José M. Padrón, Andrea Petreni, Alessio Nocentini, Claudiu T. Supuran, Óscar López, José G. Fernández-Bolaños
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 168-177 (2022)
We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and XII. Substituents on C-3 and/or C-4 positions of the coumarin scaffold, and on the
Externí odkaz:
https://doaj.org/article/a6eef15339bd494b8cace42877923ed9
Autor:
Mónica Martínez-Montiel, Laura L. Romero-Hernández, Simone Giovannuzzi, Paloma Begines, Adrián Puerta, Ana I. Ahuja-Casarín, Miguel X. Fernandes, Penélope Merino-Montiel, Sara Montiel-Smith, Alessio Nocentini, José M. Padrón, Claudiu T. Supuran, José G. Fernández-Bolaños, Óscar López
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9401 (2023)
The involvement of carbonic anhydrases (CAs) in a myriad of biological events makes the development of new inhibitors of these metalloenzymes a hot topic in current Medicinal Chemistry. In particular, CA IX and XII are membrane-bound enzymes, respons
Externí odkaz:
https://doaj.org/article/a4496264b52546eaa59e6d1a313ac174
Autor:
Tereza Cristina Santos Evangelista, Óscar López, Sabrina Baptista Ferreira, José G. Fernández-Bolaños, Magne O. Sydnes, Emil Lindbäck
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1658-1663 (2021)
The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhi
Externí odkaz:
https://doaj.org/article/d61cbdc315484d868f3fc5e950cdaea6
Autor:
Ana I. Ahuja-Casarín, Penélope Merino-Montiel, José Luis Vega-Baez, Sara Montiel-Smith, Miguel X. Fernandes, Irene Lagunes, Inés Maya, José M. Padrón, Óscar López, José G. Fernández-Bolaños
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 138-146 (2021)
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic
Externí odkaz:
https://doaj.org/article/c92efde9bb9247df94bfcbcfbdc69f9c
Autor:
Marianne B. Haarr, Óscar Lopéz, Ljupcho Pejov, José G. Fernández-Bolaños, Emil Lindbäck, Magne O. Sydnes
Publikováno v:
ACS Omega, Vol 5, Iss 29, Pp 18507-18514 (2020)
Externí odkaz:
https://doaj.org/article/6bb8cee591724f2b85a2d237179958bd