Zobrazeno 1 - 10
of 92
pro vyhledávání: '"José Fernando Díaz"'
Autor:
Jesús Urquiza, Miguel Ángel Cuesta-Geijo, Isabel García-Dorival, Óscar Fernández, Ana del Puerto, José Fernando Díaz, Covadonga Alonso
Publikováno v:
Viruses, Vol 16, Iss 3, p 349 (2024)
African swine fever virus (ASFV) belongs to the family of Asfarviridae, part of the group of nucleocytoplasmic large DNA viruses (NCLDV). Little is known about the internalization of ASFV in the host cell and the fusion membrane events that take plac
Externí odkaz:
https://doaj.org/article/193b6c1a04014803a173a849f25fb45a
Autor:
Nathália Moreno Cury, Tobias Mühlethaler, Angelo Brunelli Albertoni Laranjeira, Rafael Renatino Canevarolo, Priscila Pini Zenatti, Daniel Lucena-Agell, Isabel Barasoain, Chunhua Song, Dongxiao Sun, Sinisa Dovat, Rosendo Augusto Yunes, Andrea Enrico Prota, Michel Olivier Steinmetz, José Fernando Díaz, José Andrés Yunes
Publikováno v:
iScience, Vol 21, Iss , Pp 95-109 (2019)
Summary: Tubulin is one of the best validated anti-cancer targets, but most anti-tubulin agents have unfavorable therapeutic indexes. Here, we characterized the tubulin-binding activity, the mechanism of action, and the in vivo anti-leukemia efficacy
Externí odkaz:
https://doaj.org/article/67ad75df1ed143b6b2d81f30461805ab
Autor:
María Ángela Oliva, Carlota Tosat-Bitrián, Lucía Barrado-Gil, Francesca Bonato, Inmaculada Galindo, Urtzi Garaigorta, Beatriz Álvarez-Bernad, Rebeca París-Ogáyar, Daniel Lucena-Agell, Juan Francisco Giménez-Abián, Isabel García-Dorival, Jesús Urquiza, Pablo Gastaminza, José Fernando Díaz, Valle Palomo, Covadonga Alonso
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3448 (2022)
Microtubule targeting agents (MTAs) have been exploited mainly as anti-cancer drugs because of their impact on cellular division and angiogenesis. Additionally, microtubules (MTs) are key structures for intracellular transport, which is frequently hi
Externí odkaz:
https://doaj.org/article/2671d7e2726042098829308ac7b619d1
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 17193-17230 (2015)
Highly sophisticated mechanisms that modulate protein structure and function, which involve synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in these mechanisms can lead to protein dysfunction as well as deleter
Externí odkaz:
https://doaj.org/article/f2de0a92db3c428696878d92e3b7c95b
Autor:
Victor García-González, José Fernando Díaz-Villanueva, Octavio Galindo-Hernández, Israel Martínez-Navarro, Gustavo Hurtado-Ureta, Abril Alicia Pérez-Arias
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2527 (2018)
Ceramides are key lipids in energetic-metabolic pathways and signaling cascades, modulating critical physiological functions in cells. While synthesis of ceramides is performed in endoplasmic reticulum (ER), which is altered under overnutrition condi
Externí odkaz:
https://doaj.org/article/c9e0af06146d4e89bbf8f91b41070072
Autor:
José Fernando Díaz
Publikováno v:
Cultura-Hombre-Sociedad, Vol 14, Iss 1 (2007)
El artículo hace un análisis del relato mítico mapuche “Treng-Treng y Kai-Kai” del quela literatura histórica y etnológica ha dejado dos versiones que se citan en este trabajo, una que entrega el jesuita D. de Rosales y otra del folclorista
Externí odkaz:
https://doaj.org/article/e4ab4d178cd840e09bc4d686466480df
Autor:
José Fernando Díaz, Yao Lu, Manish A. Shah, Dan L. Sackett, Katsuhiro Kita, Isabel Barasoain, Holly V. Goodson, Neel Madhukar, Olivier Elemento, Prashant V. Thakkar, Paraskevi Giannakakou, Arindam RoyChoudhury, Henrik Molina, Urko del Castillo, Giuseppe Galletti, Elena Vila Navarro
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Dev Cell
instname
Dev Cell
73 p.-5 fig.-1 tab.-11 fig supl.-2 vid. supl.
Taxanes are widely used cancer chemotherapeutics. However, intrinsic resistance limits their efficacy without any actionable resistance mechanism. We have discovered a microtubule (MT) plus-end-bindi
Taxanes are widely used cancer chemotherapeutics. However, intrinsic resistance limits their efficacy without any actionable resistance mechanism. We have discovered a microtubule (MT) plus-end-bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a391ce7ea10498f1dc41227a96fb44e
http://hdl.handle.net/10261/256206
http://hdl.handle.net/10261/256206
Autor:
Sabine Kienesberger, Maksym Kitsera, Ronald A. Glabonjat, Jakob Pletz, Stefan Schild, José Fernando Díaz, Isabel Barasoain, Daniel Lucena, Joanna I. Loizou, Georg Schneditz, Rolf Breinbauer, Ellen L. Zechner, Lisa Pöltl, Katrin Unterhauser, Christian Lembacher-Fadum, Fernando Josa-Prado, Elisabeth Dornisch, Marc Wiedner, Wolfgang Kroutil, Gregor Gorkiewicz, Sandro Roier, Christoph Högenauer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
10 p.-6 fig.
Establishing causal links between bacterial metabolites and human intestinal disease is a significant challenge. This study reveals the molecular basis of antibiotic-associated hemorrhagic colitis (AAHC) caused by intestinal residen
Establishing causal links between bacterial metabolites and human intestinal disease is a significant challenge. This study reveals the molecular basis of antibiotic-associated hemorrhagic colitis (AAHC) caused by intestinal residen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3208ade831a4ea76067a72009476607
https://doi.org/10.1073/pnas.1819154116
https://doi.org/10.1073/pnas.1819154116
Autor:
Prashant V. Thakkar, Katsuhiro Kita, Urko del Castillo, William G. Stone, Giuseppe Galletti, Neel Madhukar, Elena Vila Navarro, Elena Barasoain, Holly V. Goodson, Dan Sackett, José Fernando Díaz, Yao Lu, Arindam RoyChoudhury, Henrik Molina, Olivier Elemento, Manish A. Shah, Paraskevi Giannakakou
Publikováno v:
Cancer Research. 82:2623-2623
Despite its widespread use, the majority of patients with gastric cancer (GC) will not respond to taxane chemotherapy due to resistance mechanisms. Recently, we reported the discovery of a novel truncated variant of the microtubule plus-end binding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1008f32a87923ce71f29afa0e041e624
https://doi.org/10.1158/1538-7445.am2022-2623
https://doi.org/10.1158/1538-7445.am2022-2623
Autor:
Daniel Lucena-Agell, Christian P. Bold, Jürg Gertsch, Karl-Heinz Altmann, Melanie Gut, Jasmine Schürmann, José Fernando Díaz
Publikováno v:
Altmann, Karl-Heinz; Bold, Christian Paul; Gut, Melanie; Schürmann, Jasmine; Lucena Agell, Daniel; Diaz, Jose Fernando; Gertsch, Jürg (2021). Synthesis of Morpholine-Based Analogs of (-)-Zampanolide and Their Biological Activity. Chemistry: a European journal, 27(19), pp. 5936-5943. Wiley 10.1002/chem.202003996
Chemistry-A European Journal, 27 (19)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Chemistry-A European Journal, 27 (19)
Digital.CSIC. Repositorio Institucional del CSIC
instname
9 p.-1 fig.-1 tab.-6 schem.
We describe the convergent synthesis of threeprototypical examples of a new class of analogues of thecomplex, cytotoxic marine macrolide ()-zampanolide thatincorporate an embedde d N-substituted morpholine moietyin
We describe the convergent synthesis of threeprototypical examples of a new class of analogues of thecomplex, cytotoxic marine macrolide ()-zampanolide thatincorporate an embedde d N-substituted morpholine moietyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856accbe44fd276d9d14e7d3b2965902
https://pubmed.ncbi.nlm.nih.gov/33078440
https://pubmed.ncbi.nlm.nih.gov/33078440