Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats.

Autor: Wanjun Qi, Maikel Acosta-Zaldivar, Peter R Flanagan, Ning-Ning Liu, Niketa Jani, José F Fierro, María T Andrés, Gary P Moran, Julia R Köhler

Publikováno v: PLoS Pathogens, Vol 18, Iss 6, p e1010089 (2022)

Whether to commit limited cellular resources toward growth and proliferation, or toward survival and stress responses, is an essential determination made by Target of Rapamycin Complex 1 (TORC1) for a eukaryotic cell in response to favorable or adver

Externí odkaz: https://doaj.org/article/8a7125990d794b918b24c90396b8f210

The Antimicrobial Activity of Human Defensins at Physiological Non-Permeabilizing Concentrations Is Caused by the Inhibition of the Plasma Membrane H+-ATPases

Autor: María T. Andrés, Patricia Fierro, Victoria Antuña, José F. Fierro

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 13, p 7335 (2024)

Human defensins are cysteine-rich peptides (Cys-rich peptides) of the innate immune system. Defensins contain an ancestral structural motif (i.e., γ-core motif) associated with the antimicrobial activity of natural Cys-rich peptides. In this study,

Externí odkaz: https://doaj.org/article/3de6571565c8448bb52a622f6e6809fb

A review on lactoferrin as a proton pump inhibitor

Autor: Cátia Santos-Pereira, María T. Andrés, José F. Fierro, Lígia R. Rodrigues, Manuela Côrte-Real

Lactoferrin (Lf) is a versatile natural milk-derived protein that exhibits multiple interesting biological activities. Since it is safe for human administration and currently manufactured using low cost and well-established large-scale processes, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77177b54108437bd6a6b108202d35f55
https://hdl.handle.net/1822/75599

Lactoferrin perturbs lipid rafts and requires integrity of Pma1p-lipid rafts association to exert its antifungal activity against Saccharomyces cerevisiae

Autor: Manuela Côrte-Real, Stéphen Manon, Lígia R. Rodrigues, Susana R. Chaves, Hernâni Gerós, Cátia Santos-Pereira, María T. Andrés, José F. Fierro

Publikováno v: International Journal of Biological Macromolecules
International Journal of Biological Macromolecules, Elsevier, 2021, 171, pp.343-357. ⟨10.1016/j.ijbiomac.2020.12.224⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

"Available online 07 January 2021"
Lactoferrin (Lf) is a bioactive milk-derived protein with remarkable wide-spectrum antifungal activity. To deepen our understanding of the molecular mechanisms underlying Lf cytotoxicity, the role of plasma mem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3632dc19750b7f540a9f18d569532a9d
https://hal.archives-ouvertes.fr/hal-03395479

Human lactoferrin triggers a mitochondrial- and caspase-dependent regulated cell death in Saccharomyces cerevisiae

Autor: Manuela Côrte-Real, José F. Fierro, António Rego, Maikel Acosta-Zaldívar, Cátia S. Pereira, María T. Andrés

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

We have previously shown that the antifungal activity of human lactoferrin (hLf) against Candida albicans relies on its ability to induce cell death associated with apoptotic markers. To gain a deeper understanding of the mechanisms underlying hLf-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7624bbe6122db67e8115e8cc7c14b7
https://doi.org/10.1007/s10495-015-1199-9