Zobrazeno 1 - 7
of 7
pro vyhledávání: '"José Eugenio de Diego"'
Autor:
Antonio Navarro, Brian A. Schaefer, J. Craig Ruble, Juan A. Rincón, María Luz de la Puente, María Jesús Trigo, María José Nieves-Remacha, José Eugenio de Diego
Publikováno v:
Organic Process Research & Development. 26:891-898
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ba6674f5a2c9e3ac608b18c1fd9bb88
https://doi.org/10.1021/acs.oprd.1c00264
https://doi.org/10.1021/acs.oprd.1c00264
Autor:
Hao Sun, Michael O. Frederick, Roger Ryan Rothhaar, Amy C. DeBaillie, Brian Morgan Watson, Carlos Mateos, Leonard L. Winneroski, Carlos Jaramillo, Talbi Kaoudi, Matthew Johnson, Pablo Garcia-Losada, Srinivas Gangula, Peter J. Lindsay-Scott, Steven James Green, Dustin J. Mergott, Dajiang Jing, Marvin M. Hansen, José Eugenio de Diego, Juan A. Rincón, Kevin D. Seibert, Lei Zhang, Jiuyuan Li
Publikováno v:
Organic Process Research & Development. 24:306-314
Herein we report a summary of the synthetic development of LY3202626 from the initial discovery route to a final route that was scaled to make 150 kg. Key developments include the use of a [3 + 2] ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd409beaf54c99668ae6510bc63b7fdb
https://doi.org/10.1021/acs.oprd.9b00471
https://doi.org/10.1021/acs.oprd.9b00471
Autor:
Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy
Publikováno v:
Journal of Medicinal Chemistry. 59:10974-10993
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119
https://doi.org/10.1021/acs.jmedchem.6b01119
Autor:
Bruce A. Dressman, Charles H. Mitch, Mercedes Carpintero, Susana García-Cerrada, John T. Catlow, Tatiana Natali Vetman, Wesley Seidel, Mark Donald Chappell, Jeffrey M. Schkeryantz, Albert Khilevich, Xushan Wang, Allie Edward Tripp, Jeffrey M. Witkin, Maria-Jesus Blanco, Renhua Li, Stephon C. Smith, José Francisco Soriano, Mario Barberis, Steven Swanson, Xia Li, Carlos Jaramillo, Beverly A. Heinz, Thomas C. Britton, Carl D Overshiner, Keith A. Wafford, Eric George Tromiczak, José Eugenio de Diego, James E. Matt, David W. Bedwell, Steven James Quimby, Adam M. Fivush, Paul L. Ornstein
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5663-5668
Negative modulators of metabotropic glutamate 2 & 3 receptors demonstrate antidepressant-like activity in animal models and hold promise as novel therapeutic agents for the treatment of major depressive disorder. Herein we describe our efforts to pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546651449b4bbed891b5bffae098620b
https://doi.org/10.1016/j.bmcl.2016.10.067
https://doi.org/10.1016/j.bmcl.2016.10.067
Autor:
Mark D, Chappell, Renhua, Li, Stephon C, Smith, Bruce A, Dressman, Eric G, Tromiczak, Allie E, Tripp, Maria-Jesus, Blanco, Tatiana, Vetman, Steven J, Quimby, James, Matt, Thomas C, Britton, Adam M, Fivush, Jeffrey M, Schkeryantz, Daniel, Mayhugh, Jon A, Erickson, Mark G, Bures, Carlos, Jaramillo, Mercedes, Carpintero, José Eugenio de, Diego, Mario, Barberis, Susana, Garcia-Cerrada, José F, Soriano, Stephen, Antonysamy, Shane, Atwell, Iain, MacEwan, Bradley, Condon, Christine, Sougias, Jing, Wang, Aiping, Zhang, Kris, Conners, Chris, Groshong, Stephen R, Wasserman, John W, Koss, Jeffrey M, Witkin, Xia, Li, Carl, Overshiner, Keith A, Wafford, Wesley, Seidel, Xu-Shan, Wang, Beverly A, Heinz, Steven, Swanson, John T, Catlow, David W, Bedwell, James A, Monn, Charles H, Mitch, Paul L, Ornstein
Publikováno v:
Journal of medicinal chemistry. 59(24)
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5baf0617bc8dab1818e329dffd2bc0c6
https://pubmed.ncbi.nlm.nih.gov/28002967
https://pubmed.ncbi.nlm.nih.gov/28002967
Autor:
Chafiq Hamdouchi, Alfonso Rivera-Sagredo, José Eugenio de Diego, Juan F. Espinosa, Carlos Jaramillo
Publikováno v:
Tetrahedron. 62:12415-12419
The dynamic NMR analysis of 2, a subunit of a new class of cyclic-dependent kinase inhibitors, reveals that the compound exists as two conformational isomers, Z and E, in acetone, as a consequence of the restricted rotation about the imidazopyridine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::589b9f81366c3d53bbdfa0560d47cdca
https://doi.org/10.1016/j.tet.2006.09.097
https://doi.org/10.1016/j.tet.2006.09.097
Autor:
Daniel H. Robertson, Boyu Zhong, Scott A. Watkins, Jose S. Mendoza, Harold B. Brooks, Charles D. Spencer, Elizabeth Collins, C. Jaramillo, José Eugenio de Diego, Bryan D. Anderson, Faming Zhang, Chafiq Hamdouchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1943-1947
Structure-based design approach was successfully used to guide the evolution of imidazopyridine scaffold yielding new structural class of highly selective inhibitors of cyclin dependent kinases that were able to form a new interaction with an identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d4fa4579860dfacc00fed8a9133bfb
https://doi.org/10.1016/j.bmcl.2005.01.052
https://doi.org/10.1016/j.bmcl.2005.01.052