Synthesis, Molecular Docking, and Preliminary Evaluation of 2‐(1,2,3‐Triazoyl)benzaldehydes As Multifunctional Agents for the Treatment of Alzheimer's Disease

Autor: Gelson Perin, Rodolfo Baldinotti, Lucielli Savegnago, Mariana G. Fronza, Fabiana Kömmling Seixas, Mariana Souza Sonego, José Edmilson R. Nascimento, Ítalo F. C. Dias, Tiago Collares, Diego Alves, Raquel G. Jacob, Gabriel P. Costa

Publikováno v: ChemMedChem. 15:610-622

We described here our results on the use of thiourea as a ligand in the copper catalysed azide-alkyne cycloaddition (CuAAC) of 2-azidobenzaldehyde with alkynes. Reactions were performed reacting 2-azidobenzaldehyde with a range of terminal alkynes us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20554134c42fd1cb2beb98d6aea4f625
https://doi.org/10.1002/cmdc.201900622

Selective Synthesis of 2-(1,2,3-Triazoyl) Quinazolinones through Copper-Catalyzed Multicomponent Reaction

Autor: Roberta Cargnelutti, José Edmilson R. Nascimento, Raquel G. Jacob, Manoela do Sacramento, Luís Pedro A. Piúma, Eder J. Lenardão, Diego Alves

Publikováno v: Catalysts
Volume 11
Issue 10
Catalysts, Vol 11, Iss 1170, p 1170 (2021)

We describe here our results from the copper-catalyzed three component reaction of 2-azidobenzaldehyde, anthranilamide and terminal alkynes, using Et3N as base, and DMSO as solvent. Depending on the temperature and amount of Et3N used in the reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee45acc2646668b261030c83fab28a51

Synthesis of (arylselanyl)- and (arylsulfenyl)-alkyl-1,2,3-triazolo-1,3,6-triazonines via a copper-catalyzed multicomponent reaction

Autor: Ítalo F. C. Dias, José Edmilson R. Nascimento, Thiago Barcellos, Eder J. Lenardão, Gelson Perin, Daniela H. de Oliveira, Thalita F.B. de Aquino, Diego Alves, Raquel G. Jacob

Publikováno v: Tetrahedron Letters. 59:1080-1083

An efficient copper-catalyzed multicomponent reaction was developed for the synthesis of (arylselanyl)- or (arylsulfenyl)-alkyl-1,2,3-triazolo-1,3,6-triazonines. The products were obtained in moderate to excellent yields via the reaction of o-phenyle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aae96930f0150fb63a2051d0a7f83021
https://doi.org/10.1016/j.tetlet.2018.01.072

Direct Synthesis of 4-Organylselanylpyrazoles by Copper- Catalyzed One-Pot Cyclocondensation and CH Bond Selenylation Reactions

Autor: Daniela H. de Oliveira, Gelson Perin, Thalita F.B. de Aquino, José Edmilson R. Nascimento, Raquel G. Jacob, Diego Alves

Publikováno v: Advanced Synthesis & Catalysis. 357:4041-4049

We describe herein an efficient protocol to synthesize selanyl-substituted pyrazoles by cyclocondensation and copper-catalyzed direct CH bond selenation reactions. The products were obtained in moderate to excellent yields by the one-pot multicompone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e90a402a1691e7bda1853077b6bd50d9
https://doi.org/10.1002/adsc.201500625

Synthesis of 4-Arylselanylpyrazoles Through Cyclocondensation Reaction Using Glycerol as Solvent

Autor: José Edmilson R. Nascimento, Diego Alves, Raquel G. Jacob, Paola B. Abib, Daniela H. de Oliveira, Gelson Perin

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 26, Issue: 8, Pages: 1533-1541, Published: AUG 2015
Journal of the Brazilian Chemical Society v.26 n.8 2015
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

We describe here a simple method to synthesize 4-arylselanylpyrazoles by reaction of α-arylselanyl-1,3-diketones with arylhydrazines using glycerol as solvent at 60 °C under N2 atmosphere. This is a direct cyclocondensation reaction performed with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7226cb33c3d7373f33c4e8cdfc93c53
https://doi.org/10.5935/0103-5053.20150127