Zobrazeno 1 - 10
of 142
pro vyhledávání: '"José E. Pérez-Ortín"'
Autor:
Bernat Blasco-Moreno, Leire de Campos-Mata, René Böttcher, José García-Martínez, Jennifer Jungfleisch, Danny D. Nedialkova, Shiladitya Chattopadhyay, María-Eugenia Gas, Baldomero Oliva, José E. Pérez-Ortín, Sebastian A. Leidel, Mordechai Choder, Juana Díez
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The exonuclease Xrn1 mediates crosstalk between transcription and mRNA decay in yeast. Here the authors demonstrate that Xrn1 promotes translation of mRNAs encoding membrane proteins, coupling transcription, translation, and mRNA decay.
Externí odkaz:
https://doaj.org/article/aa2f9afce7424f7ba3c5864b73c1260c
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
In eukaryotic cells, three nuclear RNA polymerases (RNA pols) carry out the transcription from DNA to RNA, and they all seem to have evolved from a single enzyme present in the common ancestor with archaea. The multiplicity of eukaryotic RNA pols all
Externí odkaz:
https://doaj.org/article/e58d9e66c7ab43cb8346b8fc1f659014
Autor:
Varinia García-Molinero, José García-Martínez, Rohit Reja, Pedro Furió-Tarí, Oreto Antúnez, Vinesh Vinayachandran, Ana Conesa, B. Franklin Pugh, José E. Pérez-Ortín, Susana Rodríguez-Navarro
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract Background Eukaryotic transcription is regulated through two complexes, the general transcription factor IID (TFIID) and the coactivator Spt–Ada–Gcn5 acetyltransferase (SAGA). Recent findings confirm that both TFIID and SAGA contribute t
Externí odkaz:
https://doaj.org/article/906169598c294a66841f677a6f77a193
Autor:
Gabriel Gutiérrez, Gonzalo Millán-Zambrano, Daniel A. Medina, Antonio Jordán-Pla, José E. Pérez-Ortín, Xenia Peñate, Sebastián Chávez
Publikováno v:
Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-22 (2017)
Abstract Background TFIIS stimulates RNA cleavage by RNA polymerase II and promotes the resolution of backtracking events. TFIIS acts in the chromatin context, but its contribution to the chromatin landscape has not yet been investigated. Co-transcri
Externí odkaz:
https://doaj.org/article/a75964c5818b48a08a08fdeaceb7a80e
Publikováno v:
Cells, Vol 10, Iss 2, p 334 (2021)
The ultimate goal of gene expression regulation is on the protein level. However, because the amounts of mRNAs and proteins are controlled by their synthesis and degradation rates, the cellular amount of a given protein can be attained by following d
Externí odkaz:
https://doaj.org/article/1d7834927b6c43c5b0fcaa72b2268f93
Autor:
Moran Kelbert, Antonio Jordán-Pla, Lola de Miguel-Jiménez, José García-Martínez, Michael Selitrennik, Adi Guterman, Noa Henig, Sander Granneman, José E Pérez-Ortín, Sebastián Chávez, Mordechai Choder
Publikováno v:
eLife, Vol 12 (2024)
To function effectively as an integrated system, the transcriptional and post-transcriptional machineries must communicate through mechanisms that are still poorly understood. Here, we focus on the zinc-finger Sfp1, known to regulate transcription of
Externí odkaz:
https://doaj.org/article/142d36e65ad542ed92936c9e6151ec17
Autor:
José E. Pérez-Ortín, Sebastián Chávez
Publikováno v:
Pérez Ortín, José Enrique Chávez, Sebastián 2022 Nucleo-cytoplasmic shuttling of RNA-binding factors: mRNA buffering and beyond Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms 1865 194849
RODERIC. Repositorio Institucional de la Universitat de Valéncia
Universitat Politècnica de Catalunya (UPC)
RODERIC. Repositorio Institucional de la Universitat de Valéncia
Universitat Politècnica de Catalunya (UPC)
Gene expression is a highly regulated process that adapts RNAs and proteins content to the cellular context. Under steady-state conditions, mRNA homeostasis is robustly maintained by tight controls that act on both nuclear transcription and cytoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d7a7da14dd33fb799bc1c6299d6b68
https://hdl.handle.net/10668/22026
https://hdl.handle.net/10668/22026
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2477
RNA biogenesis in eukaryotic cells is a tightly regulated multilayered process in which a diverse set of players act in an orchestrated manner via complex molecular interactions to secure the initial flow of gene expression. Transcription from DNA to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab9d5825a3bb12464649d0157195bb42
https://pubmed.ncbi.nlm.nih.gov/35524111
https://pubmed.ncbi.nlm.nih.gov/35524111
A feedback mechanism controls rDNA copy number evolution in yeast independently of natural selection
Autor:
Vicente Arnau, Marina Barba-Aliaga, Gaurav Singh, Javier Ferri, José García-Martínez, José E. Pérez-Ortín
Publikováno v:
Arnau Llombart, Vicente Barba-Aliaga, Marina Singh, Gaurav Ferri, Javier García Martínez, José Pérez Ortín, José Enrique 2022 A feedback mechanism controls rDNA copy number evolution in yeast independently of natural selection Plos One 17 9 e0272878
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
Ribosomal DNA (rDNA) is the genetic loci that encodes rRNA in eukaryotes. It is typically arranged as tandem repeats that vary in copy number within the same species. We have recently shown that rDNA repeats copy number in the yeast Saccharomyces cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9cfae246bb26ecc1749bf8bf3cfd267
https://pubmed.ncbi.nlm.nih.gov/36048821
https://pubmed.ncbi.nlm.nih.gov/36048821
It has become increasingly clear in the last few years that gene expression in eukaryotes is not a linear process starting from transcription in the nucleus to the cytoplasm, but a circular one where the mRNA level is controlled by crosstalk between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c4c3de8cc765524e76b16b1769ab732
https://doi.org/10.1101/2022.04.19.488766
https://doi.org/10.1101/2022.04.19.488766