Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity

Autor: Ajay C Donepudi, Michael J. Goedken, John D. Schuetz, José E Manautou

Publikováno v: Toxicology Reports, Vol 6, Iss , Pp 841-849 (2019)

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver injury in humans and a common chemical model to investigate genetic determinants of susceptibility to drug-induced liver injury (DILI). Previous studies performed in our l

Externí odkaz: https://doaj.org/article/9d39768750864a239724d3c9f4fff986

Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs

Autor: Julia M. Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P. Rasmussen, José E. Manautou, Xiao-bo Zhong

Publikováno v: Drug Metabolism and Disposition. 50:888-897

Absorption, distribution, metabolism, and excretion (ADME) are the key biologic processes for determination of a drug's pharmacokinetic parameters, which have direct impacts on efficacy and adverse drug reactions (ADRs). The chemical structures, dosa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8badcd590cdfac7739fde0c32db32410
https://doi.org/10.1124/dmd.121.000417

Casimersen for the treatment of Duchenne muscular dystrophy

Autor: Shahab Edalatian Zakeri, Sai Pallavi Pradeep, Vishal Kasina, Ankit P. Laddha, José E. Manautou, Raman Bahal

Publikováno v: Trends in pharmacological sciences. 43(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6bd4397b5ec2c4582c9cf72cbefbf2
https://pubmed.ncbi.nlm.nih.gov/35581038

The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites

Autor: Carolina Inés Ghanem, José E. Manautou, Renato J. Scialis

Publikováno v: Current Research in Toxicology, Vol 1, Iss, Pp 34-41 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Current Research in Toxicology

During the course of a toxic challenge, changes in gene expression can manifest such as induction of metabolizing enzymes as a compensatory detoxification response. We currently report that a single 400 mg/kg acetaminophen (APAP) dose to C57BL/6J mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df814e4c222da8ae59787676297f1bb
http://www.sciencedirect.com/science/article/pii/S2666027X20300050

Rethinking subthreshold effects in regulatory chemical risk assessments

Autor: Evgenios Agathokleous, Damià Barceló, Michael Aschner, Ricardo Antunes Azevedo, Prosun Bhattacharya, David Costantini, G. Christopher Cutler, Alessandra De Marco, Anca Oana Docea, José G. Dórea, Stephen O. Duke, Thomas Efferth, Despo Fatta-Kassinos, Vasileios Fotopoulos, Antonio Ginebreda, Raul Narciso C. Guedes, A. Wallace Hayes, Ivo Iavicoli, Olga-Ioanna Kalantzi, Takayoshi Koike, Demetrios Kouretas, Manish Kumar, José E. Manautou, Michael N. Moore, Elena Paoletti, Josep Peñuelas, Yolanda Picó, Russel J. Reiter, Ramin Rezaee, Jörg Rinklebe, Teresa Rocha-Santos, Pierre Sicard, Christian Sonne, Christopher Teaf, Aristidis Tsatsakis, Alexander I. Vardavas, Wenjie Wang, Eddy Y. Zeng, Edward J. Calabrese

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Agathokleous, E, Barceló, D, Aschner, M, Azevedo, R A, Bhattacharya, P, Costantini, D, Cutler, G C, De Marco, A, Docea, A O, Dórea, J G, Duke, S O, Efferth, T, Fatta-Kassinos, D, Fotopoulos, V, Ginebreda, A, Guedes, R N C, Hayes, A W, Iavicoli, I, Kalantzi, O I, Koike, T, Kouretas, D, Kumar, M, Manautou, J E, Moore, M N, Paoletti, E, Peñuelas, J, Picó, Y, Reiter, R J, Rezaee, R, Rinklebe, J, Rocha-Santos, T, Sicard, P, Sonne, C, Teaf, C, Tsatsakis, A, Vardavas, A I, Wang, W, Zeng, E Y & Calabrese, E J 2022, ' Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments ', Environmental Science and Technology, vol. 56, no. 16, pp. 11095-11099 . https://doi.org/10.1021/acs.est.2c02896
Digital.CSIC. Repositorio Institucional del CSIC
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A great number of dose–response studies indicate that hormesis is a common phenomenon, occurring in numerous organisms exposed to singular or combined environmental stressors, such as pharmaceuticals, heavy metals, micro/nanoplastics, organic flame

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d10fd0cfae0b850bf78fa59c25304c