Lipidomic alterations in the cerebral cortex and white matter in sporadic Alzheimer’s disease

Autor: Elia Obis, Joaquim Sol, Pol Andres-Benito, Meritxell Martín-Gari, Natàlia Mota-Martorell, José Daniel Galo-Licona, Gerard Piñol-Ripoll, Manuel Portero-Otin, Isidro Ferrer, Mariona Jové, Reinald Pamplona

AimsNon-targeted lipidomics analysis was conducted in post-mortem human frontal cortex area 8 (GM) and white matter of the frontal lobecentrum semi-ovale(WM) to identify lipidomes in middle-aged individuals with no neurofibrillary tangles and senile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41adfa6882a3476dbb2e81e7d7b47087
https://doi.org/10.1101/2022.11.04.515175

Ischemia preconditioning induces an adaptive response that defines a circulating metabolomic signature in ischemic stroke patients

Autor: Joaquim Sol, Laura Colàs-Campàs, Gerard Mauri-Capdevila, Jessica Molina-Seguin, José Daniel Galo-Licona, Coral Torres-Querol, Núria Aymerich, Ángel Ois, Jaume Roquer, Silvia Tur, María del Carmen García-Carreira, Joan Martí-Fàbregas, Antonio Cruz-Culebras, Tomás Segura, Reinald Pamplona, Manel Portero-Otín, Gloria Arqué, Mariona Jové, Francisco Purroy

Publikováno v: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Transient ischemic attacks (TIAs) before an acute ischemic stroke (AIS) could induce ischemic tolerance (IT) phenomena. with an endogenous neuroprotective role (Ischemic preconditioning. IPC). A consecutive prospective cohort of patients with AIS wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad29f19077c09bd7a48e416964acc361
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11946

Methionine transsulfuration pathway is upregulated in long-lived humans

Autor: Joaquim Sol, Consuelo Borrás, José Daniel Galo-Licona, Reinald Pamplona, Mariona Jové, Josep Puig, Jose Viña, Rebeca Berdún, Irene Pradas, Èlia Obis, Natalia Mota-Martorell, Rosanna Cabré

Publikováno v: Free radical biology & medicine
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname

Available evidences point to methionine metabolism as a key target to study the molecular adaptive mechanisms underlying differences in longevity. The plasma methionine metabolic profile was determined using a LC-MS/MS platform to systematically defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2df44fcbe3e4afb654f70067be8ca8
https://pubmed.ncbi.nlm.nih.gov/33271279

Age-Related Changes in Lipidome of Rat Frontal Cortex and Cerebellum Are Partially Reversed by Methionine Restriction Applied in Old Age

Autor: Manuel Portero-Otin, Reinald Pamplona, Èlia Obis, Joaquim Sol, José Daniel Galo-Licona, Victoria Ayala, Meritxell Martín-Gari, Paula Ramos, Mariona Jové, Pascual Torres, Rosanna Cabré, Natalia Mota-Martorell, Iván Canales, Lara Nogueras, Isidro Ferrer

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
International Journal of Molecular Sciences, Vol 22, Iss 12517, p 12517 (2021)
Repositorio Abierto de la UdL
Universitad de Lleida
International Journal of Molecular Sciences
Volume 22
Issue 22

Lipids are closely associated with brain structure and function. However, the potential changes in the lipidome induced by aging remain to be elucidated. In this study, we used chromatographic techniques and a mass spectrometry-based approach to eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d4363a02e395affadc7f32004ee5e4
https://doi.org/10.3390/ijms222212517

The lipidome fingerprint of longevity

Autor: Natalia Mota-Martorell, Èlia Obis, Reinald Pamplona, Irene Pradas, Meritxell Martín-Gari, Joaquim Sol, José Daniel Galo-Licona, Mariona Jové

Publikováno v: Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Molecules
Recercat. Dipósit de la Recerca de Catalunya
instname
Repositorio Abierto de la UdL
Universitad de Lleida
Molecules, Vol 25, Iss 4343, p 4343 (2020)

Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cace9964f6cd0670d93d96959f930ec
http://hdl.handle.net/10459.1/70244