Zobrazeno 1 - 10
of 11
pro vyhledávání: '"José D. Medina"'
Publikováno v:
Cancer Biology & Therapy. 4:329-335
Solid tumors are often placed under stress conditions, such as glucose starvation which may result in topoisomerase II drug resistance. In this study, we investigated whether glucose deprivation or substitution by fructose regulates tumor cell apopto
Publikováno v:
Biochemical and Biophysical Research Communications. 297:943-949
Full length Mcl-1 is an anti-apoptotic protein consisting of two closely migrating 42/40 kDa species. We now investigated the relationship of these isoforms to the expression of cell cycle stimulatory (cyclin A) and inhibitory (p21WAF1) proteins and
Autor:
José D. Medina, Rosabel Torrellas Hidalgo, Tatsuhiko Nakano, Maria Aracelis Maillo, Alfonso Martín
Publikováno v:
Natural Product Letters. 12:139-143
An efficient method for the synthesis of methyl 12α-hydroxy-isocopal-13(14)en-15-oate (2), a key intermediate to a variety of sesterterpene marine sponge metabolites, is described.
Publikováno v:
International Journal of Pharmacognosy. 35:227-231
A study of Tabebuia ochracea ssp. neochrysantha, a plant traditionally used in the Amazon against malaria, was pursued. Bioactivity was tested in vitro against Plasmodium berghei and Plasmodium falciparum (FcB2 chloroquine-resistant strain). Inhibito
Autor:
Dinorah Avila, José D. Medina
Publikováno v:
Journal of Natural Products. 56:1586-1589
From the seed-pods of Eperua purpurea (Leguminosae), several diterpenoids were isolated and their structures determined on the basis of spectroscopic evidence. A new clerodane-type diterpene whose structure we assign as (-)-cleroda-7,13E-dien-15-oic
Publikováno v:
Journal of Natural Products. 55:845-850
The structure of a new diterpene isolated from the seed pods of Eperua Leucantha has been determined by spectroscopic evidence as (-)-7β-hydroxycleroda-8(17), 13E-dien-15-oic acid, isolated as its methyl ester, 1. Norhardwikiic acid, 16-oxo-15, 16H-
Autor:
Fredyc Diaz, José D. Medina
Publikováno v:
Journal of Natural Products. 59:423-424
Activity-directed fractionation of the inner stem bark of Tabebuia ochracea ssp. neochrysanta led to the isolation of two new naphtho[2,3-b]furan-4,9-diones, the 5,8-dihydroxy-2-(1‘-hydroxyethyl) and 2-acetyl-7-methoxy-8-hydroxy derivatives, 1 and
Autor:
Dinorah Avila, José D. Medina
Publikováno v:
Phytochemistry. 30:3474-3475
From the seed-pods of Eperua purpurea a cis -clerodane diterpenoid was isolated. The structure, proposed from spectroscopic evidence, corresponds to (13 E -2-oxo-5α- cis -17α,20α-cleroda-3,13-diene-15-oic acid.
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1349-1352
A highly efficient total synthesis of (±)-12-deoxyscalaradial (1d), a representative of the scalaradials from marine sponges, is described. (±)-Labda-8(20),13-dien-15-oic acid (3), chosen as the starting material, was transformed to the known tricy
Autor:
José D. Medina, A B Jesús Sequera, O Francesca Creazzola De, A Dagoberto Pacheco, Vienna De Santis De M
Publikováno v:
International Journal of Chemical Kinetics. 14:599-603
The kinetics of formation of the 1:1 complexes of some dialkyl-2,2′-bipyridyl-5,5′-dicarboxylates with the ion of Ni(II) have been determined by the stopped-flow spectrophotometric method. Second-order formation rate constants have been correlate