Zobrazeno 1 - 10 of 56 pro vyhledávání: '"José C. RODRÍGUEZ-REY"'
1
Akademický článek
Coaxial Synthesis of PEI-Based Nanocarriers of Encapsulated RNA-Therapeutics to Specifically Target Muscle Cells
Autor: Raquel de la Hoz, Nazely Diban, María T. Berciano, Carlos San Emeterio, Ane Urtiaga, Miguel Lafarga, José C. Rodríguez-Rey, Olga Tapia
Publikováno v: Biomolecules, Vol 12, Iss 8, p 1012 (2022)
In this work, we performed a methodological comparative analysis to synthesize polyethyleneimine (PEI) nanoparticles using (i) conventional nanoprecipitation (NP), (ii) electrospraying (ES), and (iii) coaxial electrospraying (CA). The nanoparticles t
Externí odkaz: https://doaj.org/article/5ecc6f46814142d3890d530444070f35
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2
Akademický článek
A mutation (−49C>T) in the promoter of the low density lipoprotein receptor gene associated with familial hypercholesterolemia
Autor: Pilar Mozas, Román Galetto, Marta Albajar, Emilio Ros, Miguel Pocoví, José C. Rodríguez-Rey
Publikováno v: Journal of Lipid Research, Vol 43, Iss 1, Pp 13-18 (2002)
We have identified a mutation (−49C>T) in the low-density lipoprotein receptor (LDLR) gene in a Spanish familial hypercholesterolemia (FH) patient. The mutation maps within repeat 3 of the LDLR gene promoter. This region binds Sp1 and collaborates
Externí odkaz: https://doaj.org/article/78d36ae15b3449a998f522cfa7cd7f51
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3
Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
Autor: Alberto González-González, Daniel García-Sánchez, Flor M. Pérez-Campo, José C. Rodríguez-Rey, Monica Dotta
Publikováno v: World Journal of Stem Cells
Mesenchymal stem cells (MSCs) are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues, their ability of homing to injury sites and their potential to differentiate into multiple cell types. Ho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b435debfd7bd6296d928c4032f187a
http://europepmc.org/articles/PMC7789121
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5
Smurf1 Silencing Using a LNA‐ASOs/Lipid Nanoparticle System to Promote Bone Regeneration
Autor: José A. Riancho, Mario Ruiz, Araceli Delgado, Patricia García-García, José C. Rodríguez-Rey, Ricardo Reyes, Carmen Évora, Flor M. Pérez-Campo
Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 12, Pp 1306-1317 (2019)
Stem Cells Translational Medicine
Stem Cells Transl Med, 8 (12), 1306-1317
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Despite the great advance of bone tissue engineering in the last few years, repair of bone defects remains a major problem. Low cell engraftment and dose‐dependent side effects linked to the concomitant administration of bone morphogenetic proteins
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f167aa9470c32d4ca3fc469117aaf881
https://doaj.org/article/ac4e467983e642cab7722f3de7caa0f3
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6
Reorganization of the nuclear compartments involved in transcription and RNA processing in myonuclei of type I spinal muscular atrophy
Autor: Miguel Lafarga, María S. Castillo-Iglesias, J. Fernando Val-Bernal, Olga Tapia, José C. Rodríguez-Rey, J. Oriol Narcis, Maria T. Berciano
Publikováno v: Histochemistry and Cell Biology. 152:227-237
Type I spinal muscular atrophy (SMA) is an autosomal recessive disorder caused by the loss or mutation of the survival motor neuron 1 (SMN1) gene. The reduction in SMN protein levels in SMA leads to the degeneration of motor neurons and muscular atro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac2be277664c23fe853dbc77e3e4208
https://doi.org/10.1007/s00418-019-01792-6
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7
Effective Osteogenic Priming of Mesenchymal Stem Cells through LNA-ASOs-Mediated Sfrp1 Gene Silencing
Autor: Carmen Évora, Patricia García-García, Alberto González-González, Daniel García-Sánchez, María I. Pérez-Núñez, Flor M. Pérez-Campo, José A. Riancho, Ricardo Reyes, José C. Rodríguez-Rey
Publikováno v: Pharmaceutics
Volume 13
Issue 8
Pharmaceutics, Volume 13, Issue 8, August 2021 Article number 1277
Pharmaceutics, Vol 13, Iss 1277, p 1277 (2021)
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Mesenchymal stem cell (MSC) transplantation has emerged as a promising approach for bone regeneration. Importantly, the beneficial effects of MSCs can be improved by modulating the expression levels of specific genes to stimulate MSC osteogenic diffe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1a85da400725d767c6ad90b09ae007
https://doi.org/10.3390/pharmaceutics13081277
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8
Mislocalization of SMN from the I-band and M-band in human skeletal myofibers in spinal muscular atrophy associates with primary structural alterations of the sarcomere
Autor: Vanesa Lafarga, José C. Rodríguez-Rey, Maria T. Berciano, Olga Tapia, María S. Castillo-Iglesias, J. Fernando Val-Bernal, Miguel Lafarga
Publikováno v: Cell and tissue research. 381(3)
Spinal muscular atrophy (SMA) is caused by a deletion or mutation of the survival motor neuron 1 (SMN1) gene. Reduced SMN levels lead to motor neuron degeneration and muscular atrophy. SMN protein localizes to the cytoplasm and Cajal bodies. Moreover
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4786e3bae53acbc66e10abf23fb7adaf
https://pubmed.ncbi.nlm.nih.gov/32676861
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9
Enhancing Survival, Engraftment, and Osteogenic Potential of Mesenchymal Stem Cells
Autor: José C. Rodríguez-Rey, Daniel García-Sánchez, Flor M. Pérez-Campo, Darío Fernández
Publikováno v: World J Stem Cells, 11 (10), 748-763
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
World Journal of Stem Cells
Mesenchymal stem cells (MSCs) are promising candidates for bone regeneration therapies due to their plasticity and easiness of sourcing. MSC-based treatments are generally considered a safe procedure, however, the long-term results obtained up to now
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ee3b4edcc8284bbd6bfd87af22146c
http://hdl.handle.net/10902/17882
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10
Rare genetic variants with large effect on triglycerides in subjects with a clinical diagnosis of familial vs nonfamilial hypertriglyceridemia
Autor: Rocio Mateo-Gallego, Fernando Civeira, Alfonso Bolado-Carrancio, Emilio Ros, Itziar Lamiquiz-Moneo, José C. Rodríguez-Rey, Montserrat Cofán, Luis Álvarez-Sala, María Jesús Pueyo, Fernando Fabiani, Isabel De Castro-Orós, Miguel Pocovi, Ana Cenarro
Publikováno v: Journal of Clinical Lipidology. 10:790-797
Background Most primary severe hypertriglyceridemias (HTGs) are diagnosed in adults, but their molecular foundations have not been completely elucidated. Objective We aimed to identify rare dysfunctional mutations in genes encoding regulators of lipo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580dccbca71264afe559068d853e9ac8
https://doi.org/10.1016/j.jacl.2016.02.010
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