Zobrazeno 1 - 10
of 43
pro vyhledávání: '"José C. R. Silva"'
Autor:
Mingyue Guo, Jinyi Wu, Chuanxin Chen, Xinggu Wang, An Gong, Wei Guan, Rowan M. Karvas, Kexin Wang, Mingwei Min, Yixuan Wang, Thorold W. Theunissen, Shaorong Gao, José C. R. Silva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to inductive medium. However, the underlying mechanisms remain obscure. Here we report that self-renewing hnPSCs spontane
Externí odkaz:
https://doaj.org/article/1c3913050d6f4fae83b1d163a97c7142
Autor:
Céline Labouesse, Bao Xiu Tan, Chibeza C. Agley, Moritz Hofer, Alexander K. Winkel, Giuliano G. Stirparo, Hannah T. Stuart, Christophe M. Verstreken, Carla Mulas, William Mansfield, Paul Bertone, Kristian Franze, José C. R. Silva, Kevin J. Chalut
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The independent control of substrate stiffness and tethering of extracellular matrix to substrates for mechanical signalling investigations remains challenging. Here the authors present StemBond hydrogels, with stable ECM tethering that can be varied
Externí odkaz:
https://doaj.org/article/2711320dd2f24be2b2c8cdd0355b3ae1
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: NANOG is a homeodomain-containing transcription factor which forms one of the hubs in the pluripotency network and plays a key role in the reprogramming of somatic cells and epiblast stem cells to naïve pluripotency. Studies have found t
Externí odkaz:
https://doaj.org/article/36d845482d3a4617a6d5571d53794f67
Autor:
Laure D Bernard, Agnès Dubois, Victor Heurtier, Véronique Fischer, Inma Gonzalez, Almira Chervova, Alexandra Tachtsidi, Noa Gil, Nick Owens, Lawrence E Bates, Sandrine Vandormael-Pournin, José C R Silva, Igor Ulitsky, Michel Cohen-Tannoudji, Pablo Navarro
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac550⟩
Bernard, L D, Dubois, A, Heurtier, V, Fischer, V, Gonzalez, I, Chervova, A, Tachtsidi, A, Gil, N, Owens, N, Bates, L E, Vandormael-Pournin, S, Silva, J C R, Ulitsky, I, Cohen-Tannoudji, M & Navarro, P 2022, ' OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency ', Nucleic Acids Research, vol. 50, no. 13, pp. 7367-7379 . https://doi.org/10.1093/nar/gkac550
Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac550⟩
Bernard, L D, Dubois, A, Heurtier, V, Fischer, V, Gonzalez, I, Chervova, A, Tachtsidi, A, Gil, N, Owens, N, Bates, L E, Vandormael-Pournin, S, Silva, J C R, Ulitsky, I, Cohen-Tannoudji, M & Navarro, P 2022, ' OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency ', Nucleic Acids Research, vol. 50, no. 13, pp. 7367-7379 . https://doi.org/10.1093/nar/gkac550
Histone H3 Lysine 9 (H3K9) methylation, a characteristic mark of heterochromatin, is progressively implemented during development to contribute to cell fate restriction as differentiation proceeds. Accordingly, in undifferentiated and pluripotent mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb549b92a0f4c49361d981c802c8fbdd
https://hal-pasteur.archives-ouvertes.fr/pasteur-03719071/file/Bernard_etal_nar_revised_final.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-03719071/file/Bernard_etal_nar_revised_final.pdf
Autor:
Ramoni Z. S. Azevedo, Charles H. X. B. Barbosa, Isaac P. Santos, José C. R. Silva, Dayse H. Pastore, Anna R. C. Costa, Claudia M. Dias, Raquel M. A. Figueira, Humberto F. M. Fortunato
Publikováno v:
Computational Science and Its Applications – ICCSA 2022 Workshops ISBN: 9783031105357
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9c059f4924bd1b3bb6ba367093b6661
https://doi.org/10.1007/978-3-031-10536-4_45
https://doi.org/10.1007/978-3-031-10536-4_45
Autor:
Bao Xiu Tan, Céline Labouesse, Carla Mulas, Alexander K. Winkel, Moritz Hofer, Christophe M. Verstreken, Chibeza C. Agley, Kevin J. Chalut, José C. R. Silva, Giuliano Giuseppe Stirparo, Paul Bertone, Kristian Franze, William Mansfield, Hannah T. Stuart
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Funder: Medical Research Council (UK) Career Development Award (G1100312/1)
Funder: Medical Research Council (UK) MR/M011089/1 Wellcome Trust-Medical Research Council core funding to the Wellcome-MRC Cambridge Stem Cell Institute
Studies of
Funder: Medical Research Council (UK) MR/M011089/1 Wellcome Trust-Medical Research Council core funding to the Wellcome-MRC Cambridge Stem Cell Institute
Studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79db56a2eb87774cd06d0a784eb5336e
https://www.repository.cam.ac.uk/handle/1810/329719
https://www.repository.cam.ac.uk/handle/1810/329719
Publikováno v:
Bates, L E, Alves, M R P & Silva, J C R 2021, ' Auxin-degron system identifies immediate mechanisms of OCT4 ', Stem Cell Reports, vol. 16, no. 7, pp. 1818-1831 . https://doi.org/10.1016/j.stemcr.2021.05.016
Stem Cell Reports
Stem Cell Reports
Summary The pluripotency factor OCT4 is essential for the maintenance of naive pluripotent stem cells in vitro and in vivo. However, the specific role of OCT4 in this process remains unknown. Here, we developed a rapid protein-level OCT4 depletion sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ee69e09f1e5945acb47bd0ed6a2c62
Autor:
Lawrence E. Bates, Jennifer Nichols, José C. R. Silva, Thorsten Boroviak, Giuliano Giuseppe Stirparo, Siarhei Hladkou, Agata Kurowski, Hannah T. Stuart, Stanley E. Strawbridge, Ayaka Yanagida
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We used single-cell whole-genome transcriptional profiling and protein quantification to investigate the role of OCT4 in establishing pluripotency in the murine embryo. Surprisingly, most pluripotency-associated factors are induced norma
Autor:
Giuliano Giuseppe Stirparo, Katsiaryna Maskalenka, Amanda Andersson-Rolf, Kathryn C Tremble, Hannah T. Stuart, Kenneth Jones, José C. R. Silva, Bon-Kyoung Koo, Paul Bertone, Aliaksandra Radzisheuskaya, Lawrence E. Bates
Publikováno v:
iScience
iScience, Vol 24, Iss 3, Pp 102153-(2021)
iScience, Vol 24, Iss 3, Pp 102153-(2021)
Summary Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da78d938dba8b4663cfaeeb6a3801f1
Autor:
Christophe M. Verstreken, Kristian Franze, Alex Winkel, Chibeza C. Agley, Moritz Hofer, Paul Bertone, William Mansfield, José C. R. Silva, Céline Labouesse, Bao Xiu Tan, Hannah T. Stuart, Kevin J. Chalut, Giuliano Giuseppe Stirparo
Studies of mechanical signalling are typically performed by comparing cells cultured on soft and stiff hydrogel-based substrates. However, it is challenging to independently and robustly control both substrate stiffness and tethering of extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f46de4f24213827ea427d4592005f5
https://doi.org/10.1101/768762
https://doi.org/10.1101/768762