Role of miRNA–mRNA Interactome in Pathophysiology of Arrhythmogenic Cardiomyopathy

Autor: Fernando Bonet, Oscar Campuzano, José Córdoba-Caballero, Mireia Alcalde, Georgia Sarquella-Brugada, Aitana Braza-Boïls, Ramon Brugada, Francisco Hernández-Torres, Maribel Quezada-Feijoo, Monica Ramos, Alipio Mangas, Juan A. G. Ranea, Rocío Toro

Publikováno v: Biomedicines, Vol 12, Iss 8, p 1807 (2024)

Arrhythmogenic cardiomyopathy is an inherited entity characterized by irregular cell–cell adhesion, cardiomyocyte death and fibro-fatty replacement of ventricular myocytes, leading to malignant ventricular arrythmias, contractile dysfunction and su

Externí odkaz: https://doaj.org/article/945d2dc181984d7480a2a40bb22752e5

Gene expression analysis method integration and co-expression module detection applied to rare glucide metabolism disorders using ExpHunterSuite

Autor: Fernando M. Jabato, José Córdoba-Caballero, Elena Rojano, Carlos Romá-Mateo, Pascual Sanz, Belén Pérez, Diana Gallego, Pedro Seoane, Juan A. G. Ranea, James R. Perkins

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract High-throughput gene expression analysis is widely used. However, analysis is not straightforward. Multiple approaches should be applied and methods to combine their results implemented and investigated. We present methodology for the compre

Externí odkaz: https://doaj.org/article/35510445a6824f5eb37caeaab2b029f1

Deepening the knowledge of rare diseases dependent on angiogenesis through semantic similarity clustering and network analysis

Autor: Raquel Pagano-Márquez, José Córdoba-Caballero, Beatriz Martínez-Poveda, Ana R Quesada, Elena Rojano, Pedro Seoane, Juan A G Ranea, Miguel Ángel Medina

Publikováno v: Briefings in Bioinformatics. 23

Background Angiogenesis is regulated by multiple genes whose variants can lead to different disorders. Among them, rare diseases are a heterogeneous group of pathologies, most of them genetic, whose information may be of interest to determine the sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdde97032fb69a5a83f7ce407fd7f8f
https://doi.org/10.1093/bib/bbac220

An improved de novo assembling and polishing of Solea senegalensis transcriptome shed light on retinoic acid signalling in larvae

Autor: James R. Perkins, Pedro Seoane, José Córdoba-Caballero, Manuel Manchado, M. Gonzalo Claros, Fernando M. Jabato

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)

Senegalese sole is an economically important flatfish species in aquaculture and an attractive model to decipher the molecular mechanisms governing the severe transformations occurring during metamorphosis, where retinoic acid seems to play a key rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2983e4aaf2988e952713d88f6e524418
http://europepmc.org/articles/PMC7691524

Evaluating, Filtering and Clustering Genetic Disease Cohorts Based on Human Phenotype Ontology Data with Cohort Analyzer

Autor: Pedro Seoane-Zonjic, Álvaro Parés-Aguilar, Belén Pérez, Elena Rojano, Fernando M. Jabato, Mercedes Serrano, James R. Perkins, José Córdoba-Caballero, Juan A. G. Ranea, D. Gallego

Publikováno v: Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 11, Iss 730, p 730 (2021)
Volume 11
Issue 8
Digital.CSIC. Repositorio Institucional del CSIC
instname

Exhaustive and comprehensive analysis of pathological traits is essential to understanding genetic diseases, performing precise diagnosis and prescribing personalized treatments. It is particularly important for disease cohorts, as thoroughly detaile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffbbbce95caec6494d2175915ec85e8
https://doi.org/10.3390/jpm11080730