Zobrazeno 1 - 10
of 269
pro vyhledávání: '"José Brea"'
Autor:
Roberto Debbag, María L. Ávila-Agüero, José Brea, Helena Brenes-Chacon, Manuel Colomé, Rodrigo de Antonio, Alejandro Díaz-Díaz, Luiza Helena Falleiros-Arlant, Gerardo Fernández, Angela Gentile, Iván Felipe Gutiérrez, Daniel Jarovsky, María del Valle Juárez, Eduardo López-Medina, Abiel Mascareñas, Sebastián Ospina-Henao, Marco A. Safadi, Xavier Sáez-Llorens, Alejandra Soriano-Fallas, Juan P. Torres, Carlos N. Torres-Martínez, Claudia Beltrán-Arroyave
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections in children around the world. The post-pandemic era has resulted in a notable increase in reported cases of RSV infections, co-circulation of other respirato
Externí odkaz:
https://doaj.org/article/dd463a114ff14c4baa28f9f29b1ecc3c
Autor:
Rubén Prieto-Díaz, Hugo Fojo-Carballo, Maria Majellaro, Tana Tandarić, Jhonny Azuaje, José Brea, María I. Loza, Jorge Barbazán, Glòria Salort, Meera Chotalia, Iván Rodríguez-Pampín, Ana Mallo-Abreu, M. Rita Paleo, Xerardo García-Mera, Francisco Ciruela, Hugo Gutiérrez-de-Terán, Eddy Sotelo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116345- (2024)
Antagonists of the A2B adenosine receptor have recently emerged as targeted anticancer agents and immune checkpoint inhibitors within the realm of cancer immunotherapy. This study presents a comprehensive evaluation of novel Biginelli-assembled pyrim
Externí odkaz:
https://doaj.org/article/49588aec46c84378975a623bef5f1ed4
Autor:
Manuel Colomé-Hidalgo, Demian Herrera, José Brea Del Castillo, Cecilia María Carrasco Sánchez, Mariana F. Dauhajre Pimentel, Anamarija Jurcev Savicevic, Issael Ramírez
Publikováno v:
Ciencia y Salud, Vol 8, Iss 1 (2024)
Introducción: Las desigualdades amenazan el progreso del país hacia la equidad y la cobertura de vacunación infantil. Siendo la cobertura inferior a la meta del 90% de la Organización Mundial de la Salud. Objetivo: Identificar los determinantes
Externí odkaz:
https://doaj.org/article/fd86a55b46ce4e47ba220b97c2de6868
Autor:
Caterina Pont, Anna Sampietro, F. Javier Pérez-Areales, Nunzia Cristiano, Agustí Albalat, Belén Pérez, Manuela Bartolini, Angela De Simone, Vincenza Andrisano, Marta Barenys, Elisabet Teixidó, Raimon Sabaté, M. Isabel Loza, José Brea, Diego Muñoz-Torrero
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 982 (2024)
Multitarget compounds have emerged as promising drug candidates to cope with complex multifactorial diseases, like Alzheimer’s disease (AD). Most multitarget compounds are designed by linking two pharmacophores through a tether chain (linked hybrid
Externí odkaz:
https://doaj.org/article/5791f1c0c9d547149cf11ce0250bfaed
Autor:
Claudia Gioé-Gallo, Sandra Ortigueira, José Brea, Iu Raïch, Jhonny Azuaje, M. Rita Paleo, Maria Majellaro, María Isabel Loza, Cristian O. Salas, Xerardo García-Mera, Gemma Navarro, Eddy Sotelo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114934- (2023)
Synthetic cannabinoid receptor agonists (SCRAs) constitute the largest and most defiant group of abuse designer drugs. These new psychoactive substances (NPS), developed as unregulated alternatives to cannabis, have potent cannabimimetic effects and
Externí odkaz:
https://doaj.org/article/3b0ddeb6be494b4382e24224b8f69591
Autor:
Antón L. Martínez, José Brea, Eduardo Domínguez, María J. Varela, Catarina Allegue, Raquel Cruz, Xavier Monroy, Manuel Merlos, Javier Burgueño, Ángel Carracedo, María Isabel Loza
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Neuronal differentiation is a complex process through which newborn neurons acquire the morphology of mature neurons and become excitable. We employed a combination of functional and transcriptomic approaches to deconvolute and identify key regulator
Externí odkaz:
https://doaj.org/article/3c8415000e0a492abd7a07ba0e186a39
Autor:
Thirumal Yempala, José Brea, María Isabel Loza, Douglas J. Matthies, Gerald Zapata-Torres, Bruce K. Cassels
Publikováno v:
ACS Omega, Vol 5, Iss 5, Pp 2260-2266 (2020)
Externí odkaz:
https://doaj.org/article/580e3768accb4d9ba7508b7456f331c1
Publikováno v:
Molecules, Vol 27, Iss 23, p 8115 (2022)
Nowadays, cancer disease seems to be the second most common cause of death worldwide. Molecular hybridization is a drug design strategy that has provided promising results against multifactorial diseases, including cancer. In this work, two series of
Externí odkaz:
https://doaj.org/article/fe001ddc423e4e8485d77494722349b8
Autor:
Andrea Bagán, José A. Morales-García, Christian Griñán-Ferré, Caridad Díaz, José Pérez del Palacio, Maria C. Ramos, Francisca Vicente, Belén Pérez, José Brea, María Isabel Loza, Mercè Pallàs, Carmen Escolano
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5408 (2022)
The impact of neurodegenerative diseases (ND) is becoming unbearable for humankind due to their vast prevalence and the lack of efficacious treatments. In this scenario, we focused on imidazoline I2 receptors (I2-IR) that are widely distributed in th
Externí odkaz:
https://doaj.org/article/23e5cfa47c79414eb18f2f525aa63824
Autor:
Antón L Martínez, José Brea, Mateo Barro, Xavier Monroy, Manuel Merlos, Javier Burgueño, María Isabel Loza
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248139 (2021)
This work tries to help overcome the lack of relevant translational screening assays, as a limitation for the identification of novel analgesics for neuropathic pain. Hyperexcitability and neurite shortening are common adverse effects of antiviral an
Externí odkaz:
https://doaj.org/article/b44644d883e54db0a1b6b4ab206fa84e