Zobrazeno 1 - 10
of 16
pro vyhledávání: '"José Barbosa Pereira P"'
Autor:
Johnny Lisboa, Cassilda Pereira, Rute D. Pinto, Inês S. Rodrigues, Liliana M. G. Pereira, Bruno Pinheiro, Pedro Oliveira, Pedro José Barbosa Pereira, Jorge E. Azevedo, Dominique Durand, Roland Benz, Ana do Vale, Nuno M. S. dos Santos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Bacterial AB toxins are secreted key virulence factors that are internalized by target cells through receptor-mediated endocytosis, translocating their enzymatic domain to the cytosol from endosomes (short-trip) or the endoplasmic reticulum
Externí odkaz:
https://doaj.org/article/d1fe976757cd43739674149450e05816
Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides
Autor:
Ana Maranha, Mafalda Costa, Jorge Ripoll-Rozada, José A. Manso, Vanessa Miranda, Vera M. Mendes, Bruno Manadas, Sandra Macedo-Ribeiro, M. Rita Ventura, Pedro José Barbosa Pereira, Nuno Empadinhas
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
The mechanism of methylmannose polysaccharide (MMP) biogenesis in nontuberculous mycobacteria (NTM) is characterized, which involves an MMP-specific hydrolase (MmpH) and a rare mannosyltransferase (ManT). MmpH and ManT structures are presented.
Externí odkaz:
https://doaj.org/article/160414c28e904d199761ec1e0d62082e
Autor:
José A. Manso, Arturo Carabias, Zsuzsa Sárkány, José M. de Pereda, Pedro José Barbosa Pereira, Sandra Macedo-Ribeiro
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT An important feature associated with Candida albicans pathogenicity is its ability to switch between yeast and hyphal forms, a process in which CaRas1 plays a key role. CaRas1 is activated by the guanine nucleotide exchange factor (GEF) CaCd
Externí odkaz:
https://doaj.org/article/91a4ad11f5194a0d9e9376efb1dace40
Autor:
Tatiana Barros Cereija, Susana Alarico, Eva C. Lourenço, José António Manso, M. Rita Ventura, Nuno Empadinhas, Sandra Macedo-Ribeiro, Pedro José Barbosa Pereira
Publikováno v:
IUCrJ, Vol 6, Iss 4, Pp 572-585 (2019)
Bacteria are challenged to adapt to environmental variations in order to survive. Under nutritional stress, several bacteria are able to slow down their metabolism into a nonreplicating state and wait for favourable conditions. It is almost universal
Externí odkaz:
https://doaj.org/article/d9339f66918d4a6d955cb6d5bc351c33
Autor:
Johnny Lisboa, Cassilda Pereira, Aline Rifflet, Juan Ayala, Mateus S. Terceti, Alba V. Barca, Inês Rodrigues, Pedro José Barbosa Pereira, Carlos R. Osorio, Francisco García-del Portillo, Ivo Gomperts Boneca, Ana do Vale, Nuno M. S. dos Santos
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
Peptidoglycan (PG) is a major component of the bacterial cell wall formed by long chains of two alternating sugars interconnected by short peptides, generating a mesh-like structure that enwraps the bacterial cell. Although PG provides structural int
Externí odkaz:
https://doaj.org/article/da0ea637a6454edbac5b7c7c248665b7
Autor:
Pedro M. Martins, Susanna Navarro, Alexandra Silva, Maria F. Pinto, Zsuzsa Sárkány, Francisco Figueiredo, Pedro José Barbosa Pereira, Francisca Pinheiro, Zuzana Bednarikova, Michał Burdukiewicz, Oxana V. Galzitskaya, Zuzana Gazova, Cláudio M. Gomes, Annalisa Pastore, Louise C. Serpell, Rostislav Skrabana, Vytautas Smirnovas, Mantas Ziaunys, Daniel E. Otzen, Salvador Ventura, Sandra Macedo-Ribeiro
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Reports on phase separation and amyloid formation for multiple proteins and aggregation-prone peptides are recurrently used to explore the molecular mechanisms associated with several human diseases. The information conveyed by these reports can be u
Externí odkaz:
https://doaj.org/article/fc44793c97ba412084f310dcf7f683f9
Autor:
Emma E. Watson, Xuyu Liu, Robert E. Thompson, Jorge Ripoll-Rozada, Mike Wu, Imala Alwis, Alessandro Gori, Choy-Theng Loh, Benjamin L. Parker, Gottfried Otting, Shaun Jackson, Pedro José Barbosa Pereira, Richard J. Payne
Publikováno v:
ACS Central Science, Vol 4, Iss 4, Pp 468-476 (2018)
Externí odkaz:
https://doaj.org/article/39f6c6008a294a2faf94d657f88622d6
Autor:
José A. Manso, Daniela Nunes-Costa, Sandra Macedo-Ribeiro, Nuno Empadinhas, Pedro José Barbosa Pereira
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Actinobacteria have long been the main source of antibiotics, secondary metabolites with tightly controlled biosynthesis by environmental and physiological factors. Phosphorylation of exogenous glucosamine has been suggested as a mechanism f
Externí odkaz:
https://doaj.org/article/e96b6303fd2544bea14cfd9d4e76843d
Autor:
Peter A. Meyer, Stephanie Socias, Jason Key, Elizabeth Ransey, Emily C. Tjon, Alejandro Buschiazzo, Ming Lei, Chris Botka, James Withrow, David Neau, Kanagalaghatta Rajashankar, Karen S. Anderson, Richard H. Baxter, Stephen C. Blacklow, Titus J. Boggon, Alexandre M. J. J. Bonvin, Dominika Borek, Tom J. Brett, Amedeo Caflisch, Chung-I Chang, Walter J. Chazin, Kevin D. Corbett, Michael S. Cosgrove, Sean Crosson, Sirano Dhe-Paganon, Enrico Di Cera, Catherine L. Drennan, Michael J. Eck, Brandt F. Eichman, Qing R. Fan, Adrian R. Ferré-D'Amaré, J. Christopher Fromme, K. Christopher Garcia, Rachelle Gaudet, Peng Gong, Stephen C. Harrison, Ekaterina E. Heldwein, Zongchao Jia, Robert J. Keenan, Andrew C. Kruse, Marc Kvansakul, Jason S. McLellan, Yorgo Modis, Yunsun Nam, Zbyszek Otwinowski, Emil F. Pai, Pedro José Barbosa Pereira, Carlo Petosa, C. S. Raman, Tom A. Rapoport, Antonina Roll-Mecak, Michael K. Rosen, Gabby Rudenko, Joseph Schlessinger, Thomas U. Schwartz, Yousif Shamoo, Holger Sondermann, Yizhi J. Tao, Niraj H. Tolia, Oleg V. Tsodikov, Kenneth D. Westover, Hao Wu, Ian Foster, James S. Fraser, Filipe R. N C. Maia, Tamir Gonen, Tom Kirchhausen, Kay Diederichs, Mercè Crosas, Piotr Sliz
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The validation and analysis of X-ray crystallographic data is essential for reproducibility and the development of crystallographic methods. Here, the authors describe a repository for crystallographic datasets and demonstrate some of the ways it cou
Externí odkaz:
https://doaj.org/article/72383da3679147f9a2668c703d709d2e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 1 (2014)
Candida albicans is a polymorphic opportunistic fungal pathogen normally residing as commensal on mucosal surfaces, skin and gastrointestinal and genitourinary tracts. However, in immunocompromised patients C. albicans can cause superficial mucosal i
Externí odkaz:
https://doaj.org/article/e97c3aa6146e46289d39e08ca0796ac6