Zobrazeno 1 - 10
of 33
pro vyhledávání: '"José B.A. Custódio"'
Publikováno v:
European Journal of Pharmacology. 764:372-378
The use of the antiestrogen tamoxifen in melanoma therapy is controversial due to the unsuccessful outcomes and a still rather unclarified mechanism of action. It seemed that the days of tamoxifen in malignant melanoma therapy were close to an end, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d0e7ea13c0be9ddf957c0179494797
https://doi.org/10.1016/j.ejphar.2015.07.023
https://doi.org/10.1016/j.ejphar.2015.07.023
Publikováno v:
Chemico-biological interactions. 277
The activation of the G protein-coupled estrogen receptor (GPER) by its specific agonist G-1 inhibits prostate cancer and 17β-estradiol-stimulated breast cancer cell proliferation. Tamoxifen (TAM), which also activates the GPER, decreases melanoma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1356044f1416b6d11736bbd9203b774d
https://pubmed.ncbi.nlm.nih.gov/28947257
https://pubmed.ncbi.nlm.nih.gov/28947257
Publikováno v:
Toxicology. 323:10-18
Tamoxifen (TAM) is routinely used in the treatment of breast carcinoma. TAM-induced liver injury remains a major concern, as TAM causes hepatic steatosis in a significant number of patients, which can progress toward steatohepatitis. Liver toxicity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cab079c24b1c0adea46e328d3225f9d
https://doi.org/10.1016/j.tox.2014.05.009
https://doi.org/10.1016/j.tox.2014.05.009
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Recent reports suggest that N-methyl-d-aspartate receptor (NMDAR) blockade by MK-801 decreases tumor growth. Thus, we investigated whether other ionotropic glutamate receptor (iGluR) antagonists were also able to modulate the proliferation of melanom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3496e3d8ccb7c1032a9053f2a1baf1f9
https://doi.org/10.1016/j.yexcr.2013.11.002
https://doi.org/10.1016/j.yexcr.2013.11.002
Autor:
José B.A. Custódio, Filomena S. G. Silva, Joana Paixão, Mariana P.C. Ribeiro, Armanda E. Santos
Publikováno v:
European Journal of Pharmacology. 715:354-362
Melanoma incidence is dramatically increasing and the available treatments beyond partial efficacy have severe side effects. Retinoids are promising anticancer agents, but their clinical use has been limited by their toxicity, although a combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba45c031a355856375e53ca07b3f5eb
https://doi.org/10.1016/j.ejphar.2013.04.038
https://doi.org/10.1016/j.ejphar.2013.04.038
Autor:
Filomena S. G. Silva, Mariana P.C. Ribeiro, Maria S. Santos, Armanda E. Santos, José B.A. Custódio
Publikováno v:
Toxicology and Applied Pharmacology. 267:104-112
Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity. It is safe and well tolerated by healthy humans, but its use requires toxicological charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddb77541396769418554a3512fe3a58
https://doi.org/10.1016/j.taap.2012.12.012
https://doi.org/10.1016/j.taap.2012.12.012
Publikováno v:
Cancer chemotherapy and pharmacology. 79(2)
Glutamate has a trophic function in the development of the central nervous system, regulating the proliferation and migration of neuronal progenitors. The resemblance between neuronal embryonic and tumor cells has paved the way for the investigation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cfa462e24ed59dca0d18651665c76d
https://pubmed.ncbi.nlm.nih.gov/27586965
https://pubmed.ncbi.nlm.nih.gov/27586965
Publikováno v:
Journal of Bioenergetics and Biomembranes. 45:261-270
17β-estradiol (E2) is considered to modulate the ATP synthase activity through direct binding to the oligomycin sensitive-conferring protein. We have previously demonstrated that E2 increases the amplitude of depolarization associated with the addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f4062c142145ef776fd8623217ca71
https://doi.org/10.1007/s10863-012-9497-1
https://doi.org/10.1007/s10863-012-9497-1
Autor:
José B.A. Custódio, Lígia Salgueiro, Marisa Machado, Carlos Cavaleiro, Augusto M. Dinis, Maria do Céu Sousa
Publikováno v:
Experimental Parasitology. 127:732-739
The present work evaluates the anti-Giardia activity of Syzygium aromaticum and its major compound eugenol. The effects were evaluated on parasite growth, adherence, viability and ultrastructure. S. aromaticum essential oil (IC(50)=134 μg/ml) and eu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869244bd57e20e17d5c54eccc800544a
https://doi.org/10.1016/j.exppara.2011.01.011
https://doi.org/10.1016/j.exppara.2011.01.011
Autor:
Antonio Moreno, Catarina R. Oliveira, Paula I. Moreira, Elsa Nunes, Raquel Seiça, Maria S. Santos, José B.A. Custódio, Paulo J. Oliveira
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 123:8-16
This study was aimed to analyse and compare the bioenergetics and oxidative status of mitochondria isolated from liver, heart and brain of ovariectomized rat females treated with 17β-estradiol (E2) and/or tamoxifen (TAM). E2 and/or TAM did not alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fafb008bf2a0614d19fcefed3cce9d
https://doi.org/10.1016/j.jsbmb.2010.09.004
https://doi.org/10.1016/j.jsbmb.2010.09.004