Zobrazeno 1 - 10
of 25
pro vyhledávání: '"José Angel Fontenla"'
The authors have requested that this preprint be removed from Research Square.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e98a31451502a88a58f4f98e24b2f980
https://doi.org/10.21203/rs.3.rs-226609/v1
https://doi.org/10.21203/rs.3.rs-226609/v1
Autor:
Gabriela Gregory Regner, José Angel Fontenla, Débora Aguirre Gonçalves, Patrícia Pereira, Pricila Pflüger, Jordana Griebler Luft, Chris Krebs
Publikováno v:
Behavioural pharmacology. 31(6)
This study aimed to investigate the possible gamma-decanolactone mechanisms of action in the GABAergic and adenosine systems using the aminophylline-induced acute crisis model and the pentylenetetrazole-induced kindling model. In the acute model, mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d66300190af2828574841a8c217e4c
https://pubmed.ncbi.nlm.nih.gov/32701527
https://pubmed.ncbi.nlm.nih.gov/32701527
Autor:
Fernanda Rodríguez-Enríquez, José Angel Fontenla, Maria João Matos, Dolores Viña, Eugenio Uriarte
Publikováno v:
Bioorganic chemistry. 101
Monoamine oxidase B (MAO-B) inhibitors are still receiving great attention as promising therapeutic agents for central nervous system disorders. This study explores, for the first time, the potential of 3-thiophenylcoumarins as in vitro and in vivo a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4ee51258e2b2777eef225d35b112e6
https://pubmed.ncbi.nlm.nih.gov/32569895
https://pubmed.ncbi.nlm.nih.gov/32569895
Autor:
Mattia Sturlese, Pedro Besada, Elias Quezada, Miguel Alonso-Pena, Stefano Moro, Carmen Terán, Dolores Viña, María Carmen Costas-Lago, Fernanda Rodríguez-Enríquez, José Angel Fontenla, Iria Torres-Terán
The 3-pyridazinylcoumarin scaffold was previously reported as an efficient core for the discovery of reversible and selective inhibitors of MAO-B, a validated drug target for PD therapy which also plays an important role in the AD progress. Looking f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156b018afc28f64a976fb7e7a10bc968
http://hdl.handle.net/11577/3349054
http://hdl.handle.net/11577/3349054
Autor:
José Angel Fontenla, Amit Kumar, Patrícia Pereira, María Isabel Loza, Dolores Viña, Pricila Pflüger, José Brea
Publikováno v:
European Journal of Pharmacology. 906:174276
Treatment of Parkinson's disease (PD) includes the use of monoamine oxidase-B (MAO-B) inhibitor drugs. In this work we have evaluated the possible gamma-decanolactone (GD) effect in vitro to inhibit the A and B isoforms of human monoamine oxidase (hM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a2cc31372d3c01b60ed9c2b1ee70a2
https://doi.org/10.1016/j.ejphar.2021.174276
https://doi.org/10.1016/j.ejphar.2021.174276
Autor:
L. Mayán, George Hripcsak, Dolores Viña, Fernanda Borges, Francesca Pintus, Santiago Vilar, Maria João Matos, José Angel Fontenla, Javier Munín, Giovanna Delogu
Publikováno v:
MedChemComm. 8:1788-1796
Monoamine oxidase (MAO) is an enzyme responsible for metabolism of monoamine neurotransmitters which play an important role in brain development and function. This enzyme exists in two isoforms, and it has been demonstrated that MAO-B activity, but n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e907863d2014f9feebe5d480f2f8682
https://doi.org/10.1039/c7md00311k
https://doi.org/10.1039/c7md00311k
Autor:
Jorge Nunez, Eduardo Sobarzo-Sánchez, Eugenio Uriarte, Seyed Mohammad Nabavi, Alejandra Herrera, José Angel Fontenla
Publikováno v:
Current Topics in Medicinal Chemistry. 15:1750-1754
Anxiety is one of the behavior disorders that has been studied more together with depression in the world, and that has enormous interference in the mental health of the affected patients. The states of panic and phobia are a part of the psychologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cb7514c1561df93a09ee460e8eb17d
https://doi.org/10.2174/1568026615666150427125535
https://doi.org/10.2174/1568026615666150427125535
Autor:
Nicholas P. Tatonetti, Rosa María González Franco, Eugenio Uriarte, Dolores Viña, Fernanda Borges, Maria João Matos, José Angel Fontenla, Santiago Vilar, Patricia Janeiro, Lourdes Santana
Publikováno v:
Future Medicinal Chemistry. 6:371-383
Background: Due to the complex etiology of neurodegenerative diseases, there is growing interest in multitarget drugs. In this study we synthesized and evaluated a new series of compounds, with benzo[f]coumarin structure, as potential inhibitors of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6882453aad6afc8afc6f8bb9bf383d61
https://doi.org/10.4155/fmc.14.9
https://doi.org/10.4155/fmc.14.9
Autor:
Ofelia Nieto, Alfonso Fernández-Mayoralas, María L. de Ceballos, Emilia Rivas, José Angel Fontenla, Caridad Fernandez
Publikováno v:
Organic & Biomolecular Chemistry. 1:767-771
Glucosyl dopamine (DA) derivatives may represent a new class of DA prodrugs that would interact with glucose transporter GLUT-1, present in the blood-brain barrier, and generate DA in the brain. Therefore, compounds bearing the sugar moiety linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99e870ad5cf3ff9e87351c5b1bd174bb
https://doi.org/10.1039/b212066f
https://doi.org/10.1039/b212066f