Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses.

Autor: Rafael Fenutría, Vanesa G Martinez, Inês Simões, Jorge Postigo, Victor Gil, Mario Martínez-Florensa, Jordi Sintes, Rodrigo Naves, Kevin S Cashman, José Alberola-Ila, Manel Ramos-Casals, Gloria Soldevila, Chander Raman, Jesús Merino, Ramón Merino, Pablo Engel, Francisco Lozano

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84895 (2014)

CD5 is a lymphoid-specific transmembrane glycoprotein constitutively expressed on thymocytes and mature T and B1a lymphocytes. Current data support the view that CD5 is a negative regulator of antigen-specific receptor-mediated signaling in these cel

Externí odkaz: https://doaj.org/article/9dfa51b3599c44d6829502301644e787

Development of αβ T Cells with Innate Functions

Autor: José, Alberola-Ila

Publikováno v: Advances in experimental medicine and biology. 1365

Although we mostly think of αβ T cells as components of the adaptive immune system, a number of them differentiate into alternative lineages. These lineages express TCRs with limited diversity, and functionally bridge the gap between innate and ada

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6cf24084b0557e7a19a4d6dc59e0a7d2
https://pubmed.ncbi.nlm.nih.gov/35567746

Multifaceted effects of soluble human CD6 in experimental cancer models

Autor: María Velasco-de Andrés, Marta Consuegra-Fernández, José Alberola-Ila, Fernando Aranda, Cristina Català, Inês Simões, Esther Carreras, Gloria González-Aseguinolaza, Sergi Casadó-Llombart, Vanesa G. Martínez, Jesús Merino, Marc Orta-Mascaró, Pilar Álvarez, Ramón Merino, Francisco Lozano

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer

© Author(s) (or their employer(s)) 2020.
[Background]: CD6 is a lymphocyte surface co-receptor physically associated with the T-cell receptor (TCR)/CD3 complex at the center of the immunological synapse. There, CD6 assists in cell-to-cell conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4049f0986f28b96b1f10650d01ada878
http://hdl.handle.net/10261/223676

Increased Level of E Protein Activity during Invariant NKT Development Promotes Differentiation of Invariant NKT2 and Invariant NKT17 Subsets

Autor: Susan Kovats, Amie Simmons, Sandra Bajana, Xiao Hong Sun, José Alberola-Ila, Taishan Hu, Hong Cheng Wang, Ying Zhao

Publikováno v: The Journal of Immunology. 191:5065-5073

E protein transcription factors and their natural inhibitors, Id proteins, play critical and complex roles during lymphoid development. In this article, we report that partial maintenance of E protein activity during positive selection results in a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89d46e95fad64351f110be2b93374b0b
https://doi.org/10.4049/jimmunol.1301546

Regulation of GATA-3 Expression during CD4 Lineage Differentiation

Autor: Meinrad Busslinger, Chi Wang, Amie Simmons, Timothy P. Bender, Gabriela Hernandez-Hoyos, Abdallah Souabni, José Alberola-Ila, Taishan Hu, Idoia Gimferrer

Publikováno v: The Journal of Immunology. 186:3892-3898

GATA-3 is necessary for the development of MHC class II-restricted CD4 T cells, and its expression is increased during positive selection of these cells. TCR signals drive this upregulation, but the signaling pathways that control this process are no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94429f8ce95338d2daa04143b2f25e9
https://doi.org/10.4049/jimmunol.1003505