Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases

Autor: Inmaculada García-Ruiz, Nerea Blanes Ruiz, Patricia Rada, Virginia Pardo, Laura Ruiz, Ana Blas-García, M. Pilar Valdecantos, Montserrat Grau Sanz, José A. Solís Herruzo, Ángela M. Valverde

Publikováno v: Redox Biology, Vol 26, Iss , Pp - (2019)

Inflammation is typically associated with the development of fibrosis, cirrhosis and hepatocellular carcinoma. The key role of protein tyrosine phosphatase 1B (PTP1B) in inflammatory responses has focused this study in understanding its implication i

Externí odkaz: https://doaj.org/article/8fbffa3db39f4ecd83a91780e231eefa

Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model

Autor: Montserrat Grau, Daniel Fernández-Moreira, M. T. Muñoz-Yagüe, Pablo Solís-Muñoz, José A. Solís-Herruzo, Inmaculada García-Ruiz

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Scientific Reports

Visceral fat deposition is associated with impairment of glucose and lipid metabolism while leptin levels are frequently related to subcutaneous fat area. At present, there is considerable controversy regarding the role of visceral adipose tissue acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7d565942f41f46e0d23a49ffd63480
https://doaj.org/article/f578f360b41c472f8cd80940b3c549b1

Interlobar Artery Resistive Index predicts Acute-on-Chronic Liver Failure Syndrome in Cirrhotic Patients with Acute Decompensation

Autor: Pablo Solís-Muñoz, José A. Solís-Herruzo, Julia Wendon, Michael A. Heneghan, Maria De la Flor-Robledo, G Auzinger, Christopher Willars

Publikováno v: Ultraschall in der Medizin (Stuttgart, Germany : 1980). 39(1)

Patients with acutely decompensated (AD) cirrhosis are at risk for developing acute-on-chronic liver failure (ACLF) syndrome. This syndrome is associated with a high short-term mortality rate. The aim of our study was to identify reliable early predi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd6b59b2f1aa75a0987c79dd7abbea9
https://pubmed.ncbi.nlm.nih.gov/28420029

Sp1 and Sp3 Transcription Factors Mediate Leptin-Induced Collagen α1(I) Gene Expression in Primary Culture of Male Rat Hepatic Stellate Cells

Autor: Teresa Muñoz-Yagüe, Erica Gómez-Izquierdo, Montserrat Grau, Pablo Solís-Muñoz, José A. Solís-Herruzo, Inmaculada García-Ruiz, Teresa Díaz-Sanjuán

Publikováno v: Endocrinology. 153:5845-5856

Mechanisms by which leptin stimulates collagen α1(I) [Col1a(I)] gene expression are unclear. The purposes of this study were to identify the trans-acting factors and cis-acting elements in Col1a(I) promoter involved in this effect as well as the pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827cacfd02c46154057178d21fcacf95
https://doi.org/10.1210/en.2012-1626

Melatonin improves mitochondrial respiratory chain activity and liver morphology in ob/ob mice

Autor: Daniel Fernández-Moreira, Teresa Muñoz-Yagüe, Pablo Solís-Muñoz, José A. Solís-Herruzo, Inés García-Consuegra, Inmaculada Garcia Ruiz, Erica Gómez-Izquierdo

Publikováno v: Journal of Pineal Research. 51:113-123

In previous studies, we have shown that mitochondrial respiratory chain (MRC) activity is decreased in patients with nonalcoholic steatohepatitis and in ob/ob mice and that peroxynitrite plays a pathogenic role. The present study examined whether mel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40b4b986f125c0f7e4d445fb21490ed0
https://doi.org/10.1111/j.1600-079x.2011.00868.x