Výsledky vyhledávání - "José A. Quincoces"

Synthesis of Tetrasubstituted Thiophenes Starting from Amino Mercaptoacrylates and α-brominated Acetamides

Autor: Carolina Passarelli Gonçalves, Alfredo Peña Ricardo, Mário Augusto Tremante, José Agustín Quincoces Suárez, José Matheus de Freitas Costa, Manuel Salustiano Almeida Saavedra

Publikováno v: Current Organic Chemistry. 25:748-756

Some thiophenic derivatives show important biological activity or are used as intermediates in organic synthesis. For this reason, it is very important to develop new synthesis procedures with good yields and using few synthesis steps. The present wo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::844ef7b8e6c134ddd196f32ba9c1ddba
https://doi.org/10.2174/1385272825666210111112449

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Abstract PS12-20: A dose escalation study of the novel oral SERD-ZN-c5 in women with ER-positive, HER2-negative advanced/metastatic breast cancer

Autor: Kevin Kalinsky, Joanne E. Mortimer, José Agustín Quincoces Suárez, Julie R. Nangia, Matt Suster, Mieke Ptaszynski, Pavani Chalasani, Vandana G. Abramson

Publikováno v: Cancer Research. 81:PS12-20

Background: ZN-c5 is an orally bioavailable selective estrogen receptor degrader (SERD) that binds potently to the estrogen receptors alpha and beta. It shows improved activity over fulvestrant in human tumor xenograft models and activity in tumor mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad34b91fd6b132f938e46b6c40860692
https://doi.org/10.1158/1538-7445.sabcs20-ps12-20

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Metalloproteinases Suppression Driven by the Curcumin Analog DM-1 Modulates Invasion in BRAF-Resistant Melanomas

Autor: Silvya Stuchi Maria-Engler, Sandra Coccuzzo Sampaio, José A. Quincoces, Luciana de Araújo Pimenta, Nayane de Souza, Fernanda Faião-Flores, Erica Aparecida de Oliveira

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Background: Melanoma is the most aggressive skin cancer, and BRAF (V600E) is the most frequent mutation that led to the development of BRAF inhibitors (BRAFi). However, patients treated with BRAFi usually present recidivism after 6-9 months. Curcumin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3742198b223ce4b740b08284808bec
https://doi.org/10.2174/1871520620666200218111422

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Akademický článek

Curcumin analog DM-1 in monotherapy or combinatory treatment with dacarbazine as a strategy to inhibit in vivo melanoma progression.

Autor: Fernanda Faião-Flores, José Agustín Quincoces Suarez, Andréa Costa Fruet, Silvya Stuchi Maria-Engler, Paulo Celso Pardi, Durvanei Augusto Maria

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0118702 (2015)

Malignant melanoma is a highly aggressive form of skin cancer with a high mortality rate if not discovered in early stages. Although a limited number of treatment options for melanoma currently exist, patients with a more aggressive form of this canc

Externí odkaz: https://doaj.org/article/b954bbab1c654da6a21d84238325ad9c

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Synthesis of New Curcumin-like Pentadienones by O- and C-glycosylation

Autor: José A. Quincoces, Dirk Michalik, Carolina P. Gonçalves, Manuel Almeida, Anderson Orzari Ribeiro

Publikováno v: Current Organic Chemistry. 23:1984-1991

A new method for the preparation of three new curcumin analogues is described by the connection of pentadienones to carbohydrate units. From L-Rhamnose and D-Galactose, several functionalization reactions were performed to obtain the desired sugar un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4c49ecb28073403054e42acc9c13b14
https://doi.org/10.2174/1385272823666191014165754

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Akademický článek

New method for synthesis of triazolo[1,5-a]pyridines from N-[bis(methylthio)methylene]cyanoacetohydrazide and push pull systems

Autor: Maribel Nápoles, Klaus Peseke, José Quincoces Quincoces, Arístides Rosado, Arturo Macías, Hermán Vélez

Publikováno v: Revista CENIC Ciencias Químicas, Vol 33, Iss 1, Pp 015-018 (2002)

The N-[bis(methylthio)methylen]cyanoacethydrazides derived from cyanoacethydrazide possess the structural requirements for the formation, in basic media of methylenic carbanions which make possible the synthesis of interesting heterocyclic systems wi

Externí odkaz: https://doaj.org/article/24f238f378cd42d49c2f98fc7c1512dc

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Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells

Autor: Silvya Stuchi Maria-Engler, Lucas Esteves Cardozo, Diógenes S. de Lima, Fernanda Faião-Flores, Erica Aparecida de Oliveira, Helder I. Nakaya, Débora Kristina Alves-Fernandes, Gisele Monteiro, Nayane de Souza, Garcia Ferreira de Souza, Silvia Berlanga de Moraes Barros, José A. Quincoces

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Melanoma is a highly invasive and metastatic cancer with high mortality rates and chemoresistance. Around 50% of melanomas are driven by activating mutations in BRAF that has led to the development of potent anti-BRAF inhibitors. However resistance t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388b892be0febea77b7a2b3c87d0329b
https://pubmed.ncbi.nlm.nih.gov/28882690

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Bcl-2 family proteins and cytoskeleton changes involved in DM-1 cytotoxic effect on melanoma cells

Autor: Vanessa Soto-Cerrato, Durvanei Augusto Maria, Ricardo Pérez-Tomás, José Agustín Quincoces Suárez, Margarita Espona-Fiedler, Fernanda Faião-Flores

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname

Melanoma is one of the most aggressive types of skin cancer and its incidence rate is still increasing. All existing treatments are minimally effective. Consequently, new therapeutic agents for melanoma treatment should be developed. The DM-1 compoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b113ae580f4382f73ee4b4cd278082
https://doi.org/10.1007/s13277-013-0666-6

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A versatile approach to novel homo-C-nucleosides based on aldehydes and acetylenic ketones derived from ribo- and 2-deoxy-ribofuranose C-glycosides

Autor: Dirk Michalik, Alexander Villinger, Udo Kragl, Dilver Peña Fuentes, José Agustín Quincoces Suárez, Heike Waechtler, Christian Vogel

Publikováno v: ARKIVOC, Vol 2012, Iss 3, Pp 110-133 (2012)

A series of ribofuranosyl- and 2-deoxyribofuranosyl homo- and spacered-C-nucleosides have been synthesized by reaction of fully protected 3-(1-deoxy-β-D-ribofuranosyl-1-yl)propanal (1), 3-(1,2-dideoxy-β-D-ribofuranos-1-yl)propanal (14), 1-(1-desoxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ad80f002f58384fbce28e6d5bf0db3
https://doi.org/10.3998/ark.5550190.0013.310

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