Zobrazeno 1 - 6
of 6
pro vyhledávání: '"José A. H. M. Bittencourt"'
Autor:
Cleydson B. R. Santos, Cleison C. Lobato, Sirlene S. B. Ota, Rai C. Silva, Renata C. V. S. Bittencourt, Jofre J. S. Freitas, Elenilze F. B. Ferreira, Marília B. Ferreira, Renata C. Silva, Anderson B. De Lima, Joaquín M. Campos, Rosivaldo S. Borges, José A. H. M. Bittencourt
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1584 (2023)
The design, synthesis, and evaluation of novel non-steroidal anti-inflammatory drugs (NSAIDs) with better activity and lower side effects are big challenges today. In this work, two 5-acetamido-2-hydroxy benzoic acid derivatives were proposed, increa
Externí odkaz:
https://doaj.org/article/3c7c83face0f40d4a86f319b8878dae4
Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach
Autor:
Luciane B. Silva, Elenilze F. B. Ferreira, Maryam, José M. Espejo-Román, Glauber V. Costa, Josiane V. Cruz, Njogu M. Kimani, Josivan S. Costa, José A. H. M. Bittencourt, Jorddy N. Cruz, Joaquín M. Campos, Cleydson B. R. Santos
Publikováno v:
Molecules, Vol 28, Iss 3, p 1035 (2023)
Acetylcholinesterase (AChE) enzymes play an essential role in the development of Alzheimer’s disease (AD). Its excessive activity causes several neuronal problems, particularly psychopathies and neuronal cell death. A bioactive pose on the hAChE B
Externí odkaz:
https://doaj.org/article/dc71a5ccb35141a8b7192fc4f562a8a2
Autor:
José A. H. M. Bittencourt, Moysés F. A. Neto, Pedro S. Lacerda, Renata C. V. S. Bittencourt, Rai C. Silva, Cleison C. Lobato, Luciane B. Silva, Franco H. A. Leite, Juliana P. Zuliani, Joaquín M. C. Rosa, Rosivaldo S. Borges, Cleydson B. R. Santos
Publikováno v:
Molecules, Vol 24, Iss 8, p 1476 (2019)
Inflammation is a complex reaction involving cellular and molecular components and an unspecific response to a specific aggression. The use of scientific and technological innovations as a research tool combining multidisciplinary knowledge in inform
Externí odkaz:
https://doaj.org/article/942b74bfcf1c4daab59a75d1fdeb01e5
Autor:
Mayara Amoras Teles Fujishima, Dayse Maria Cunha Sá, Carolina Miranda de Sousa Lima, José Adolfo H M Bittencourt, Washington Luiz Assunção Pereira, Abraão de Jesus Barbosa Muribeca, Consuelo Yumiko Yoshioka E Silva, Milton Nascimento da Silva, Francisco Fábio Oliveira de Sousa, Cleydson B R Dos Santos, Jocivania Oliveira da Silva
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0225514 (2020)
Based on ethnopharmacological studies, a lot of plants, as well as its compounds, have been investigated for the potential use as wound healing agents. In Brazil, Curatella americana is traditionally used by local people to treat wounds, ulcers and i
Externí odkaz:
https://doaj.org/article/8af820cda65447549b5cb2b43dd60b17
Autor:
Josinete B. Vieira, Francinaldo S. Braga, Cleison C. Lobato, César F. Santos, Josivan S. Costa, José Adolfo H. M. Bittencourt, Davi S. B. Brasil, Jocivânia O. Silva, Lorane I. S. Hage-Melim, Williams Jorge C. Macêdo, José Carlos T. Carvalho, Cleydson Breno R. Santos
Publikováno v:
Molecules, Vol 19, Iss 8, Pp 10670-10697 (2014)
The Density Functional Theory (DFT) method and the 6-31G** basis set were employed to calculate the molecular properties of artemisinin and 20 derivatives with different degrees of cytotoxicity against the human hepatocellular carcinoma HepG2 line. P
Externí odkaz:
https://doaj.org/article/56cb1f4946d04c30bc6b25ee8d73dc51
Autor:
Josiane V. Cruz, Moysés F. A. Neto, Luciane B. Silva, Ryan da S. Ramos, Josivan da S. Costa, Davi S. B. Brasil, Cleison C. Lobato, Glauber V. da Costa, José Adolfo H. M. Bittencourt, Carlos H. T. P. da Silva, Franco H. A. Leite, Cleydson B. R. Santos
Publikováno v:
Molecules, Vol 23, Iss 2, p 453 (2018)
The Protein Kinase Receptor type 2 (RIPK2) plays an important role in the pathogenesis of inflammatory diseases; it signals downstream of the NOD1 and NOD2 intracellular sensors and promotes a productive inflammatory response. However, excessive NOD2
Externí odkaz:
https://doaj.org/article/954e5774ae6d4a7a9510004fac054c88