Zobrazeno 1 - 10 of 31 pro vyhledávání: '"José A. Gómez-Vidal"'
1
Akademický článek
Effectiveness of an O-Alkyl Hydroxamate in Dogs with Naturally Acquired Canine Leishmaniosis: An Exploratory Clinical Trial
Autor: Victoriano Corpas-López, Victoriano Díaz-Sáez, Francisco Morillas-Márquez, Francisco Franco-Montalbán, Mónica Díaz-Gavilán, Julián López-Viota, Margarita López-Viota, José Antonio Gómez-Vidal, Joaquina Martín-Sánchez
Publikováno v: Animals, Vol 12, Iss 19, p 2700 (2022)
Canine leishmaniosis is a challenge in veterinary medicine and no drug to date has achieved parasite clearance in dogs. Histone deacetylase inhibitors are a drug class widely used in cancer chemotherapy. We have successfully used O-alkyl hydroxamates
Externí odkaz: https://doaj.org/article/e2e7a3f31bac45138ed58707bc3b46bf
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3
Akademický článek
Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells
Autor: David Méndez-Luna, Loreley Araceli Morelos-Garnica, Juan Benjamín García-Vázquez, Martiniano Bello, Itzia Irene Padilla-Martínez, Manuel Jonathan Fragoso-Vázquez, Alfonso Dueñas González, Nuria De Pedro, José Antonio Gómez-Vidal, Humberto Lubriel Mendoza-Figueroa, José Correa-Basurto
Publikováno v: Pharmaceuticals, Vol 14, Iss 1, p 49 (2021)
The implementation of chemo- and bioinformatics tools is a crucial step in the design of structure-based drugs, enabling the identification of more specific and effective molecules against cancer without side effects. In this study, three new compoun
Externí odkaz: https://doaj.org/article/adf3f9207ef946e0acee2c9d6a74b139
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4
Effectiveness of an
Autor: Victoriano, Corpas-López, Victoriano, Díaz-Sáez, Francisco, Morillas-Márquez, Francisco, Franco-Montalbán, Mónica, Díaz-Gavilán, Julián, López-Viota, Margarita, López-Viota, José Antonio, Gómez-Vidal, Joaquina, Martín-Sánchez
Publikováno v: Animals : an open access journal from MDPI. 12(19)
Canine leishmaniosis is a challenge in veterinary medicine and no drug to date has achieved parasite clearance in dogs. Histone deacetylase inhibitors are a drug class widely used in cancer chemotherapy. We have successfully used
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6eab2bcdd312eb3dbddcee40cbc8dad0
https://pubmed.ncbi.nlm.nih.gov/36230441
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5
Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured Cells
Autor: Manuel Jonathan Fragoso-Vázquez, José A. Gómez-Vidal, Emilie Marhuenda, Bakalara Norbert, Yudibeth Sixto-López, Martha Cecilia Rosales-Hernández, José Correa-Basurto, Juan Benjamín García-Vázquez, David Cornu, Oscar J. Zacarías‐Lara, David Méndez-Luna
Publikováno v: Cellular and Molecular Neurobiology. 42:1909-1920
Glioblastoma multiforme (GBM) is account for 70% of all primary malignancies of the central nervous system. Median The survival of human patients after treatment is around 15 months. There are However, several biological targets which have been repor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1574847d409bddd95100c8d109f3f6f3
https://doi.org/10.1007/s10571-021-01072-9
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7
In silico design of HDAC6 inhibitors with neuroprotective effects
Autor: Yudibeth Sixto-Lopez, José Correa-Basurto, Martiniano Bello, José A. Gómez-Vidal, Martha Cecilia Rosales-Hernández, Nuria de Pedro
Publikováno v: Journal of biomolecular structuredynamics. 40(24)
HDAC6 has emerged as a molecular target to treat neurodegenerative disorders, due to its participation in protein aggregate degradation, oxidative stress process, mitochondrial transport, and axonal transport. Thus, in this work we have designed a se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d09e5f7fbd350cc1dc2f2b24ba6415
https://pubmed.ncbi.nlm.nih.gov/34784487
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8
A nanodelivered Vorinostat derivative is a promising oral compound for the treatment of visceral leishmaniasis
Autor: Margarita López-Viota, Francisco Morillas-Márquez, Victoriano Corpas-López, Joaquina Martín-Sánchez, José Pérez del Palacio, Nuria de Pedro, Efres Belmonte-Reche, José A. Gómez-Vidal, Julián López-Viota, Mónica Díaz-Gavilán, Gemma Merino-Espinosa, Francisco Franco-Montalban
Publikováno v: Pharmacological Research. 139:375-383
There is currently no satisfactory treatment for visceral leishmaniasis; the disease is thus in desperate need of novel drugs. The ideal candidate should be effective, safe, affordable, and administered via the oral route. Histone deacetylases (HDACs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd67def1d6da6f2d29906c6f0146799
https://doi.org/10.1016/j.phrs.2018.11.039
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9
Small Molecule-Based Enzyme Inhibitors in the Treatment of Primary Hyperoxalurias
Autor: José A. Gómez-Vidal, Maria Dolores Moya-Garzon, Joaquín Altarejos, Alfonso Alejo-Armijo, Sofía Salido, Miguel X. Fernandes, Mónica Díaz-Gavilán, Juan R. Rodriguez-Madoz, Eduardo Salido
Publikováno v: Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 11, Iss 74, p 74 (2021)
Primary hyperoxalurias (PHs) are a group of inherited alterations of the hepatic glyoxylate metabolism. PHs classification based on gene mutations parallel a variety of enzymatic defects, and all involve the harmful accumulation of calcium oxalate cr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a13ef3bad0af5f03ad5aca67ead7e3
https://pubmed.ncbi.nlm.nih.gov/33513899
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10
Hydroxamic acid derivatives as HDAC1, HDAC6 and HDAC8 inhibitors with antiproliferative activity in cancer cell lines
Autor: José A. Gómez-Vidal, Yudibeth Sixto-López, Martha Cecilia Rosales-Hernández, Nuria de Pedro, José Correa-Basurto, Martiniano Bello
Publikováno v: Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Histone deacetylases (HDACs) belong to a family of enzymes that remove acetyl groups from the ɛ-amino of histone and nonhistone proteins. Additionally, HDACs participate in the genesis and development of cancer diseases as promising therapeutic targ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d31bdd23a713bf819c41943fd7a6cf
http://hdl.handle.net/10481/63205
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