Zobrazeno 1 - 10
of 100
pro vyhledávání: '"José A M, Borghans"'
Autor:
Josien Lanfermeijer, Koen van de Ven, Harry van Dijken, Marion Hendriks, Cami M. P. Talavera Ormeño, Femke de Heij, Paul Roholl, José A. M. Borghans, Debbie van Baarle, Jørgen de Jonge
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract CD8 + T cells are promising targets for vaccination against influenza A virus (IAV) infection. Their induction via peptide vaccination is not trivial, because peptides are weakly immunogenic. One strategy to overcome this is by vaccination w
Externí odkaz:
https://doaj.org/article/dcf333a662a7405bb9eb73687aa9e066
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
We have previously argued that the antigen receptors of T and B lymphocytes evolved to be sufficiently specific to avoid massive deletion of clonotypes by negative selection. Their optimal ‘specificity’ level, i.e., probability of binding any par
Externí odkaz:
https://doaj.org/article/af6df0c92e9e4353bb4807749fa84229
Autor:
Josien Lanfermeijer, Koen van de Ven, Marion Hendriks, Harry van Dijken, Stefanie Lenz, Martijn Vos, José A. M. Borghans, Debbie van Baarle, Jørgen de Jonge
Publikováno v:
Vaccines, Vol 12, Iss 4, p 419 (2024)
To protect older adults against influenza A virus (IAV) infection, innovative strategies are imperative to overcome the decrease in protective immune response with age. One approach involves the boosting of CD8+ T cells at middle age that were previo
Externí odkaz:
https://doaj.org/article/1443c322a32b4f41befdae381878c67b
Autor:
Peter C. de Greef, Josien Lanfermeijer, Marion Hendriks, Alper Cevirgel, Martijn Vos, José A. M. Borghans, Debbie van Baarle, Rob J. de Boer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T cells recognize pathogens by their highly specific T-cell receptor (TCR), which can bind small fragments of an antigen presented on the Major Histocompatibility Complex (MHC). Antigens that are provided through vaccination cause specific T cells to
Externí odkaz:
https://doaj.org/article/afb7e7e73a364e1094fcc54460087e70
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A timely recovery of T-cell numbers following haematopoietic stem-cell transplantation (HSCT) is essential for preventing complications, such as increased risk of infection and disease relapse. In analogy to the occurrence of lymphopenia-induced prol
Externí odkaz:
https://doaj.org/article/4a21d3946b3c48a0817487930e1a8ee2
Finding Gene Regulatory Networks in Psoriasis: Application of a Tree-Based Machine Learning Approach
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Psoriasis is a chronic inflammatory skin disorder. Although it has been studied extensively, the molecular mechanisms driving the disease remain unclear. In this study, we utilized a tree-based machine learning approach to explore the gene regulatory
Externí odkaz:
https://doaj.org/article/b1e2b6b740f041a7b0d479ecff4499c3
Autor:
Sara P H van den Berg, Lyanne Y Derksen, Julia Drylewicz, Nening M Nanlohy, Lisa Beckers, Josien Lanfermeijer, Stephanie N Gessel, Martijn Vos, Sigrid A Otto, Rob J de Boer, Kiki Tesselaar, José A M Borghans, Debbie van Baarle
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010152 (2021)
Cytomegalovirus (CMV) infection has a major impact on the T-cell pool, which is thought to be associated with ageing of the immune system. The effect on the T-cell pool has been interpreted as an effect of CMV on non-CMV specific T-cells. However, it
Externí odkaz:
https://doaj.org/article/75fa94e444bf43b9ac20d94ea3bccc0d
Autor:
Sara P. H. van den Berg, Josien Lanfermeijer, Ronald H. J. Jacobi, Marion Hendriks, Martijn Vos, Roos van Schuijlenburg, Nening M. Nanlohy, José A. M. Borghans, Josine van Beek, Debbie van Baarle, Jelle de Wit
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Latent infection with cytomegalovirus (CMV) is assumed to contribute to the age-associated decline of the immune system. CMV induces large changes in the T-cell pool and may thereby affect other immune responses. CMV is expected to impact especially
Externí odkaz:
https://doaj.org/article/48600be757ac4c13aa1cc289914a90e5
Autor:
Josien Lanfermeijer, Marieke M. Nühn, Maarten E. Emmelot, Martien C. M. Poelen, Cécile A. C. M. van Els, José A. M. Borghans, Debbie van Baarle, Patricia Kaaijk, Jelle de Wit
Publikováno v:
Vaccines, Vol 9, Iss 12, p 1431 (2021)
Waning of the mumps virus (MuV)-specific humoral response after vaccination has been suggested as a cause for recent mumps outbreaks in vaccinated young adults, although it cannot explain all cases. Moreover, CD8+ T cells may play an important role i
Externí odkaz:
https://doaj.org/article/c1b6f70462924d1b8ff7186e8c560174
Publikováno v:
Immunological Reviews.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f47bfba546b319f8bc767d04d5bdc291
https://doi.org/10.1111/imr.13211
https://doi.org/10.1111/imr.13211