Mitochondrionopathy phenotype in doxorubicin-treated Wistar rats depends on treatment protocol and is cardiac-specific.

Autor: Gonçalo C Pereira, Susana P Pereira, Claudia V Pereira, José A Lumini, José Magalhães, António Ascensão, Maria S Santos, António J Moreno, Paulo J Oliveira

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38867 (2012)

Although doxorubicin (DOX) is a very effective antineoplastic agent, its clinical use is limited by a dose-dependent, persistent and cumulative cardiotoxicity, whose mechanism remains to be elucidated. Previous works in animal models have failed to u

Externí odkaz: https://doaj.org/article/6fea09ef794c4b668ff8324d968ff3cc

Early Cardiac Mitochondrial Molecular and Functional Responses to Acute Anthracycline Treatment in Wistar Rats

Autor: Antonio Moreno, Kendall B. Wallace, Francisco B. Pereira, Mariusz R. Wieckowski, Gonçalo C. Pereira, Nuno Lourenço, Paulo J. Oliveira, José A. Lumini, Claudia V. Pereira, José Magalhães, António Ascensão, Susana P. Pereira, James A. Bjork

Publikováno v: Pereira, G C, Pereira, S P, Pereira, F B, Lourenço, N, Lumini, J A, Pereira, C V, Bjork, J A, Magalhães, J, Ascensão, A, Wieckowski, M R, Moreno, A J, Wallace, K B & Oliveira, P J 2019, ' Early Cardiac Mitochondrial Molecular and Functional Responses to Acute Anthracycline Treatment in Wistar Rats ', Toxicological Sciences, vol. 169, no. 1, pp. 137-150 . https://doi.org/10.1093/toxsci/kfz026

Doxorubicin (DOX) is an anticancer drug widely used to treat human and nonhuman tumors but the late and persistent cardio-toxicity reduces the therapeutic utility of the drug. The full mechanism(s) of DOX-induced acute, subchronic and delayed toxicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b914f9d2fbf032b2206e6d7eb5a5dee
https://pubmed.ncbi.nlm.nih.gov/30698778

Beneficial effects of exercise on muscle mitochondrial function in diabetes mellitus

Autor: Paulo J. Oliveira, António Ascensão, José A. Lumini, José Magalhães

Publikováno v: Sports medicine (Auckland, N.Z.). 38(9)

The physiopathology of diabetes mellitus has been closely associated with a variety of alterations in mitochondrial histology, biochemistry and function. Generally, the alterations comprise increased mitochondrial reactive oxygen and nitrogen species

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e55bbae2eda887ae97a9943d18c04b
https://pubmed.ncbi.nlm.nih.gov/18712941

Cross Tolerance Effect Of Endurance Training Against In Vitro Cardiac Mitochondrial Dysfunction In Diabetes

Autor: António Ascensão, Paulo J. Oliveira, Claudia V. Pereira, José A. Lumini, José Magalhães

Publikováno v: Medicine & Science in Sports & Exercise. 41:330

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f872aa059b7622436256680eed1795d2
https://doi.org/10.1249/01.mss.0000355555.98634.5e

Endurance Training Improves Gastrocnemius Mitochondrial Respiratory Function Despite Increasing Mtptp Susceptibility In Diabetes

Autor: Claudia V. Pereira, José Magalhães, Paulo J. Oliveira, António Ascensão, José A. Lumini

Publikováno v: Medicine & Science in Sports & Exercise. 41:60

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e471cfd5acc9faa7e0724d29acdf19bf
https://doi.org/10.1249/01.mss.0000353452.91576.6d