Zobrazeno 1 - 10
of 79
pro vyhledávání: '"José A Aínsa"'
Autor:
Alan Hibbitts, Ainhoa Lucía, Inés Serrano-Sevilla, Laura De Matteis, Michael McArthur, Jesús M de la Fuente, José A Aínsa, Fabrice Navarro
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0220684 (2019)
Bacterial resistance to antibiotics is widely regarded as a major public health concern with last resort MRSA treatments like vancomycin now encountering resistant strains. TFDs (Transcription Factor Decoys) are oligonucleotide copies of the DNA-bind
Externí odkaz:
https://doaj.org/article/1f54707cacf14147862f50babde9db7f
Autor:
Ritwik Maity, Xuepei Zhang, Francesca Romana Liberati, Chiara Scribani Rossi, Francesca Cutruzzolá, Serena Rinaldo, Massimiliano Gaetani, José Antonio Aínsa, Javier Sancho
Publikováno v:
eLife, Vol 13 (2024)
Antimicrobial resistance is responsible for an alarming number of deaths, estimated at 5 million per year. To combat priority pathogens, like Helicobacter pylori, the development of novel therapies is of utmost importance. Understanding the molecular
Externí odkaz:
https://doaj.org/article/8e9d33b85838437486c00c392fcb85a6
Autor:
Marta Gómara-Lomero, Ana Isabel López-Calleja, Antonio Rezusta, José Antonio Aínsa, Santiago Ramón-García
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Treatment of infections caused by multi-drug resistant (MDR) enterobacteria remains challenging due to the limited therapeutic options available. Drug repurposing could accelerate the development of new urgently needed successful interventio
Externí odkaz:
https://doaj.org/article/137fccfbf7324ea3b7035da0a8fe40e2
Autor:
Juan José Galano-Frutos, Ritwik Maity, Verónica Iguarbe, José Antonio Aínsa, Adrián Velázquez-Campoy, Ulrich E. Schaible, Uwe Mamat, Javier Sancho
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e27982- (2024)
Objectives: The rise of antibiotic-resistant Streptococcus pneumoniae (Sp) poses a significant global health threat, urging the quest for novel antimicrobial solutions. We have discovered that the human hormone l-thyroxine has antibacterial propertie
Externí odkaz:
https://doaj.org/article/8ff036fbc27f4af08e6460f717ca866d
Autor:
Lilha Beyria, Ophelie Gourbeyre, Sandra Salillas, Alejandro Mahía, María Dolores Díaz de Villegas, José Antonio Aínsa, Javier Sancho, Alain Bousquet-Mélou, Aude A. Ferran
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Antimicrobial resistance of Helicobacter pylori (Hp) threatens currently available treatment regimens and prompts the development of antimicrobial drugs against new bacterial targets. One such class of drugs is Hp-flavodoxin (Hp-fld) inhibit
Externí odkaz:
https://doaj.org/article/e10be5dd66d14037b0528cf0d30efbd3
Publikováno v:
Antibiotics, Vol 12, Iss 2, p 335 (2023)
Mycobacterium kansasii (Mkn) causes tuberculosis-like lung infection in both immunocompetent and immunocompromised patients. Current standard therapy against Mkn infection is lengthy and difficult to adhere to. Although β-lactams are the most import
Externí odkaz:
https://doaj.org/article/5a32d3b73bbf4c9096ef8f733f82e467
Autor:
Salvatore Calogero Gaglio, Ylenia Jabalera, Manuel Montalbán-López, Ana Cristina Millán-Placer, Marina Lázaro-Callejón, Mercedes Maqueda, María Paz Carrasco-Jimenez, Alejandro Laso, José A. Aínsa, Guillermo R. Iglesias, Massimiliano Perduca, Concepción Jiménez López
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2744 (2022)
Among the strategies employed to overcome the development of multidrug-resistant bacteria, directed chemotherapy combined with local therapies (e.g., magnetic hyperthermia) has gained great interest. A nano-assembly coupling the antimicrobial peptide
Externí odkaz:
https://doaj.org/article/73ff8bb076dc40cc8c8c2cfb12405205
Autor:
María Sebastián, Ernesto Anoz-Carbonell, Begoña Gracia, Pilar Cossio, José Antonio Aínsa, Isaías Lans, Milagros Medina
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 241-254 (2018)
The increase of bacterial strains resistant to most of the available antibiotics shows a need to explore novel antibacterial targets to discover antimicrobial drugs. Bifunctional bacterial FAD synthetases (FADSs) synthesise the flavin mononucleotide
Externí odkaz:
https://doaj.org/article/beb86d6928d8420e91a7fe0893108a42
Autor:
Fernando Sanz-García, Ernesto Anoz-Carbonell, Esther Pérez-Herrán, Carlos Martín, Ainhoa Lucía, Liliana Rodrigues, José A. Aínsa
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Aminoglycoside acetyltransferases are important determinants of resistance to aminoglycoside antibiotics in most bacterial genera. In mycobacteria, however, aminoglycoside acetyltransferases contribute only partially to aminoglycoside susceptibility
Externí odkaz:
https://doaj.org/article/84950555c822450289135d3f1a2a2ed5
Autor:
Marta Gómara-Lomero, Ana Isabel López-Calleja, Antonio Rezusta, José A. Aínsa, Santiago Ramón-García
BackgroundNew therapeutical strategies are urgently needed against multidrug-resistant (MDR) Enterobacterales. Azithromycin is a widely prescribed antibiotic with additional immunomodulatory properties, but traditionally underused for the treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b452784ff7ce754c79bf1f5a18e2c9c6
https://doi.org/10.1101/2022.07.03.498633
https://doi.org/10.1101/2022.07.03.498633
