Zobrazeno 1 - 10 of 141 pro vyhledávání: '"Jos, Van Pelt"'
1
Akademický článek
Aldehyde Dehydrogenase 2 (ALDH2): A novel sorafenib target in hepatocellular carcinoma unraveled by the proteome-wide cellular thermal shift assay
Autor: Inês C. Ferreira, Estefania Torrejón, Bernardo Abecasis, Bruno M. Alexandre, Ricardo A. Gomes, Chris Verslype, Jos van Pelt, Ana Barbas, Daniel Simão, Tiago M. Bandeiras, Alessio Bortoluzzi, Sofia P. Rebelo
Publikováno v: SLAS Discovery, Vol 29, Iss 3, Pp 100154- (2024)
Sorafenib is a multikinase inhibitor indicated for first-line treatment of unresectable hepatocellular carcinoma. Despite its widespread use in the clinic, the existing knowledge of sorafenib mode-of-action remains incomplete. To build upon the curre
Externí odkaz: https://doaj.org/article/f74d704ab68c4276ae4077cfc067a125
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2
Akademický článek
Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality
Autor: Jos van Pelt, Bob Meeusen, Rita Derua, Liesbeth Guffens, Eric Van Cutsem, Veerle Janssens, Chris Verslype
Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has a low survival, its incidence is rising and little therapeutic improvements are expected in the near future. It has been observed that Epithelial-to-Mesenchymal transition (EMT) contribu
Externí odkaz: https://doaj.org/article/62e9bee916614108bb722b3a189cf40e
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3
Akademický článek
Predicting Therapeutic Efficacy of Vascular Disrupting Agent CA4P in Rats with Liver Tumors by Hepatobiliary Contrast Agent Mn-DPDP-Enhanced MRI
Autor: Yewei Liu, Qiu Guan, Xiangyong Kong, Frederik De Keyzer, Yuanbo Feng, Feng Chen, Jie Yu, Jianjun Liu, Shaoli Song, Jos van Pelt, Johan Swinnen, Guy Bormans, Raymond Oyen, Shuncong Wang, Gang Huang, Yicheng Ni, Yue Li
Publikováno v: Translational Oncology, Vol 13, Iss 1, Pp 92-101 (2020)
To evaluate hepatobiliary-specific contrast agent (CA) mangafodipir trisodium (Mn-DPDP)–enhanced magnetic resonance imaging (MRI) for predicting the therapeutic efficacy of the vascular disrupting agent combretastatin A4 phosphate (CA4P) in rats wi
Externí odkaz: https://doaj.org/article/634fff80f6df4f6ebf33f2602b80e634
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4
Akademický článek
Gemcitabine Recruits M2-Type Tumor-Associated Macrophages into the Stroma of Pancreatic Cancer
Autor: Ashenafi Bulle, Jeroen Dekervel, Lise Deschuttere, David Nittner, Louis Libbrecht, Rekin's Janky, Stéphane Plaisance, Baki Topal, An Coosemans, Diether Lambrechts, Eric Van Cutsem, Chris Verslype, Jos van Pelt
Publikováno v: Translational Oncology, Vol 13, Iss 3, Pp - (2020)
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a very lethal disease that can develop therapy resistance over time. The dense stroma in PDAC plays a critical role in tumor progression and resistance. How this stroma interacts with the tumor c
Externí odkaz: https://doaj.org/article/f33a3cab75764fc9b9021cd603bf7566
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5
Akademický článek
Protective effects of Mentha piperita L. leaf essential oil against CCl4 induced hepatic oxidative damage and renal failure in rats
Autor: Khaled Bellassoued, Anis Ben Hsouna, Khaled Athmouni, Jos van Pelt, Fatma Makni Ayadi, Tarek Rebai, Abdelfattah Elfeki
Publikováno v: Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-14 (2018)
Abstract Background Mentha piperita L. is a flowering plant belonging to the Lamiaceae family. Mentha plants constitute one of the main valuable sources of essential oil used in foods and for medicinal purposes. Methods The present study aimed to inv
Externí odkaz: https://doaj.org/article/27a159e8dd214fbfb13cccb1ec414b28
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6
Akademický článek
Acriflavine Inhibits Acquired Drug Resistance by Blocking the Epithelial-to-Mesenchymal Transition and the Unfolded Protein Response
Autor: Jeroen Dekervel, Ashenafi Bulle, Petra Windmolders, Diether Lambrechts, Eric Van Cutsem, Chris Verslype, Jos van Pelt
Publikováno v: Translational Oncology, Vol 10, Iss 1, Pp 59-69 (2017)
Epithelial-to-mesenchymal transition (EMT) is linked to tumor invasion, drug resistance and aggressive disease and this is largely dependent on the cell's microenvironment. Acriflavine (ACF) is an old antibacterial drug recently also suggested as ant
Externí odkaz: https://doaj.org/article/9ecd17c5405b45699472247722a98faf
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8
Akademický článek
A Global Risk Score (GRS) to Simultaneously Predict Early and Late Tumor Recurrence Risk after Resection of Hepatocellular Carcinoma
Autor: Jeroen Dekervel, Dusan Popovic, Hannah van Malenstein, Petra Windmolders, Line Heylen, Louis Libbrecht, Ashenafi Bulle, Bart De Moor, Eric Van Cutsem, Frederik Nevens, Chris Verslype, Jos van Pelt
Publikováno v: Translational Oncology, Vol 9, Iss 2, Pp 139-146 (2016)
OBJECTIVES: Recurrence of hepatocellular carcinoma can arise from the primary tumor (“early recurrence”) or de novo from tumor formation in a cirrhotic environment (“late recurrence”). We aimed to develop one simple gene expression score appl
Externí odkaz: https://doaj.org/article/ee27325fc2184131a1e39b62f1cafe74
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