Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jory R. Baldridge"'
Autor:
Jory R. Baldridge, Jay T. Evans, Yufeng Li, Alyson J. Smith, Daniel Larocque, Hélène G. Bazin, Julien R. St-Jean
Publikováno v:
Vaccine. 34:4304-4312
Small-molecule adjuvants that boost and direct adaptive immunity provide a powerful means to increase the effectiveness of vaccines. Through rational design several novel imidazoquinoline and oxoadenine TLR7/8 agonists, each with unique molecular mod
Publikováno v:
Journal of Endotoxin Research. 12:313-319
Monophosphoryl lipid A (MPL®) is a potent vaccine adjuvant derived from Salmonella minnesota that was recently licensed in Europe as a component of an improved vaccine for hepatitis B (Fendrix®). MPL, like lipopolysaccharide from which it is derive
Autor:
Richard J. Ulevitch, Michael J. Lacy, Jean da Silva Correia, Jory R. Baldridge, Eric W. Jeffery, Peter Probst, Cluff Christopher W, Axel G. Stöver, Johnson David A, Mark Elliott, Robert M. Hershberg, David H. Persing, Jay T. Evans
Publikováno v:
Journal of Biological Chemistry. 279:4440-4449
Important questions remain regarding the impact of variations in the structure of the lipid A portion of lipopolysaccharide on activation of cells via the Toll-like receptor 4 complex. We have studied a series of synthetic lipid A mimetic compounds k
Autor:
Jeffrey R. Stephens, Jay T. Evans, Johnson David A, Cluff Christopher W, David H. Persing, Jon R. Ward, Rong Wang, Yvonne M. Yorgensen, Michael J. Lacy, Valerie G. Brookshire, Jory R. Baldridge
Publikováno v:
Journal of Endotoxin Research. 8:453-458
Earlier we showed that the structural requirements for adjuvanticity among the aminoalkyl glucosaminide 4-phosphate (AGP) class of synthetic immunostimulants may be less strict than those for other endotoxic activities, including the induction of nit
Autor:
Jon R. Ward, Jory R. Baldridge
Publikováno v:
Vaccine. 15:395-401
Vaccines utilizing poorly immunogenic subunit antigens are dependent upon adjuvants to drive the appropriate T cell responses. In an effort to determine the ability of several adjuvants to promote cell-mediated immunity (CMI), we assessed delayed-typ
Publikováno v:
Virology. 197:669-677
The effects of viral infection on the developing nervous system and the potential of passive immunotherapy to protect against infection were examined. When 4-day-old Lewis rats were injected intracerebrally with lymphocytic choriomeningitis virus (LC
Autor:
Johnson David A, Jory R. Baldridge
Publikováno v:
Vaccine Adjuvants and Delivery Systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd07a1bf800823fe471656c11fa28ff
https://doi.org/10.1002/9780470134931.ch6
https://doi.org/10.1002/9780470134931.ch6
Autor:
Johnson David A, Myers Kent R, Jory R. Baldridge, David H. Persing, Cluff Christopher W, Robert M. Hershberg
Publikováno v:
Vaccine Adjuvants ISBN: 9780896038929
MPL adjuvant, a monophosphoryl lipid A (MLA) derivative of the lipopolysaccharide (LPS) from Salmonella minnesota R595, and RC-529, a synthetic lipid A mimetic, are promising adjuvant candidates for a number of human vaccines and have been shown to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8ea7f40bc88385dca4e81768ca61dc7
https://doi.org/10.1007/978-1-59259-970-7_12
https://doi.org/10.1007/978-1-59259-970-7_12
Autor:
Jay T. Evans, Jory R. Baldridge, Patrick Mcgowan, Johnson David A, Christopher Cuff, David H. Persing, Sally Mossman
Publikováno v:
Immunopotentiators in Modern Vaccines ISBN: 9780120884032
Publisher Summary Lipopolysaccharide (LPS), the major component of the Gram-negative bacterial cell wall, has long been known as a powerful immunomodulator. Despite its well-known ability to enhance immune responses, LPS is considered too toxic by cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c8b43d3402af3f266f943bc3794d2ac
https://doi.org/10.1016/b978-012088403-2/50007-1
https://doi.org/10.1016/b978-012088403-2/50007-1
Autor:
Axel G. Stöver, Johnson David A, Robert M. Hershberg, Michael J. Lacy, Jay T. Evans, David H. Persing, Vonnie M. Yorgensen, Cluff Christopher W, Valerie G. Clawson, Craig L. Johnson, Jory R. Baldridge, Mark T. Livesay
Publikováno v:
Infection and immunity. 73(5)
A compound family of synthetic lipid A mimetics (termed the aminoalkyl glucosaminide phosphates [AGPs]) was evaluated in murine infectious disease models of protection against challenge with Listeria monocytogenes and influenza virus. For the Listeri