Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jory A. Goldsmith"'
Autor:
Nuria de Zavalia, Konrad Schoettner, Jory A. Goldsmith, Pavel Solis, Sarah Ferraro, Gabrielle Parent, Shimon Amir
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
In order to examine the role of the circadian clock driver Brain and Muscle ARNT-Like 1 (Bmal1) in alcohol consumption, de Zavalia et al assess the effects of (Bmal1) deletion in the mouse striatum on alcohol drinking behavior. They show that striata
Externí odkaz:
https://doaj.org/article/581860bc417042edb0b9db7a1f1d2a53
Autor:
Andrea M. DiVenere, Dzifa Amengor, Rui P. Silva, Jory A. Goldsmith, Jason S. McLellan, Jennifer A. Maynard
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Bordetella produces an array of virulence factors, including the adenylate cyclase toxin (ACT), which is essential, immunogenic in humans, and highly conserved. Despite mediating immune-evasive functions as a leukotoxin, ACT’s potential ro
Externí odkaz:
https://doaj.org/article/362d14f34aae418bae944b32e8cf4808
Autor:
Lorenzo Casalino, Zied Gaieb, Jory A. Goldsmith, Christy K. Hjorth, Abigail C. Dommer, Aoife M. Harbison, Carl A. Fogarty, Emilia P. Barros, Bryn C. Taylor, Jason S. McLellan, Elisa Fadda, Rommie E. Amaro
Publikováno v:
ACS Central Science, Vol 6, Iss 10, Pp 1722-1734 (2020)
Externí odkaz:
https://doaj.org/article/e60b1ddf27e84d1fb235d7cde4477f45
Autor:
Ching-Lin Hsieh, Anne P. Werner, Sarah R. Leist, Laura J. Stevens, Ester Falconer, Jory A. Goldsmith, Chia-Wei Chou, Olubukola M. Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J. Fritch, Kenneth H. Dinnon, III, Alexandra Schäfer, Mark R. Denison, James D. Chappell, Ralph S. Baric, Barney S. Graham, Kizzmekia S. Corbett, Jason S. McLellan
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109929- (2021)
Summary: Current coronavirus (CoV) vaccines primarily target immunodominant epitopes in the S1 subunit, which are poorly conserved and susceptible to escape mutations, thus threatening vaccine efficacy. Here, we use structure-guided protein engineeri
Externí odkaz:
https://doaj.org/article/af2791637eea401ba71a9731ca3cb5c0
Publikováno v:
Journal of Bacteriology. 205
Clostridioides difficile strains associated with worse clinical outcomes have been found to secrete a toxin called CDT (or binary toxin). As blocking the function of this toxin could help mitigate C. difficile infections, we sought to determine the m
Autor:
Pavel Solis, Sarah Ferraro, Shimon Amir, Konrad Schoettner, Jory A. Goldsmith, Gabrielle Parent, Nuria de Zavalia
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
Alcohol consumption has been strongly associated with circadian clock gene expression in mammals. Analysis of clock genes revealed a potential role of Bmal1 in the control of alcohol drinking behavior. However, a causal role of Bmal1 and neural pathw
Autor:
Jason S. McLellan, Lorenzo Casalino, Evan Seitz, Ghoncheh Mashayekhi, Anthony T. Bogetti, Suvrajit Maji, Francisco Acosta-Reyes, Lillian T. Chong, Abbas Ourmazd, J. Andrew McCammon, Ryan S McCool, Rommie E. Amaro, Jory A. Goldsmith, Surl-Hee Ahn, Fiona L. Kearns, Terra Sztain, Joachim Frank
Publikováno v:
Nature Chemistry. 13:963-968
SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding domain (RBD), which transitions from a glycan-shielded 'down' to an exposed 'up' state to bind the human angiotensin-converting enzyme 2 receptor and infect cells
Autor:
Kizzmekia S. Corbett, Barney S. Graham, Jason S. McLellan, Jory A. Goldsmith, Olubukola M. Abiona, Ching-Lin Hsieh, Daniel Wrapp, Nianshuang Wang
Publikováno v:
Science
Science (New York, N.y.)
bioRxiv
article-version (status) pre
article-version (number) 1
Science (New York, N.y.)
bioRxiv
article-version (status) pre
article-version (number) 1
Structure of the nCoV trimeric spike The World Health Organization has declared the outbreak of a novel coronavirus (2019-nCoV) to be a public health emergency of international concern. The virus binds to host cells through its trimeric spike glycopr
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009920 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009920 (2021)
RTX leukotoxins are a diverse family of prokaryotic virulence factors that are secreted by the type 1 secretion system (T1SS) and target leukocytes to subvert host defenses. T1SS substrates all contain a C-terminal RTX domain that mediates recruitmen
Publikováno v:
Cell Reports. 40:111196
Integrins are ubiquitous cell-surface heterodimers that are exploited by pathogens and toxins, including leukotoxins that target β