Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jorrit J. Hornberg"'
Autor:
Guanghui Liu, Catherine Betts, Danen M. Cunoosamy, Per M. Åberg, Jorrit J. Hornberg, Kinga Balogh Sivars, Taylor S. Cohen
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Animal models remain invaluable for study of respiratory diseases, however, translation of data generated in genetically homogeneous animals housed in a clean and well-controlled environment does not necessarily provide insight to the human
Externí odkaz:
https://doaj.org/article/a9cf2c514e3449689fd595ad4b0b503b
Publikováno v:
BioTechniques, Vol 33, Iss 1, Pp 108-117 (2002)
Nylon membrane-based macroarrays form a widely available alternative to microarrays for the collection of large-scale gene expression data. To carry out repetitive hybridization experiments with nylon cDNA arrays, we used phosphorothioate 33P-cDNA, f
Externí odkaz:
https://doaj.org/article/b9053384e3864d1e8e87c1c9bdb2853b
Autor:
Suresh Poda, Robb Brodbeck, Veena Menon, Manuel Cajina, Elena Dale, Annemette V. Thougaard, Martin Juhl, Londye Calice, Hopper Allen T, Thomas Möller, Roland G. W. Staal, Michel Grenon, Stevin H. Zorn, Kenneth A. Jones, Gamini Chandrasena, Tanzilya Khayrullina, Jorrit J. Hornberg, Lassina Badolo, John Paul Kilburn, Dekun Song, Adarsh Gandhi, Megan Nattini, Hong Zhang, Christian Thomsen, Gennady N. Smagin
Publikováno v:
Journal of Medicinal Chemistry. 64:4891-4902
There remains an insufficient number of P2X7 receptor antagonists with adequate rodent potency, CNS permeability, and pharmacokinetic properties from which to evaluate CNS disease hypotheses preclinically. Herein, we describe the molecular pharmacolo
Autor:
Taylor S. Cohen, Kinga Balogh Sivars, Jorrit J. Hornberg, Catherine J. Betts, Guanghui Liu, Per M. Åberg, Danen Cunoosamy
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Respiratory Research
Respiratory Research
Animal models remain invaluable for study of respiratory diseases, however, translation of data generated in genetically homogeneous animals housed in a clean and well-controlled environment does not necessarily provide insight to the human disease s
Publikováno v:
Current Opinion in Toxicology. 15:99-108
The safety profile of a novel drug candidate is highly determinant of its chance of success to be launched for treatment of patients. The integration of predictive toxicology in the drug discovery process is essential to identify and mitigate potenti
Publikováno v:
Archives of Toxicology
Autor:
Martijn J. Wilmer, Ernst Ahlberg, Mikael Persson, Simone H. Stahl, Anna-Karin Sjögren, Malin Forsgard, Jorrit J. Hornberg, Lucas Milton, Katarina Breitholtz
Publikováno v:
Archives of Toxicology, 92, 3175-3190
Archives of Toxicology, 92, 10, pp. 3175-3190
Archives of Toxicology, 92, 10, pp. 3175-3190
Contains fulltext : 196765.pdf (Publisher’s version ) (Closed access) Drug-induced nephrotoxicity is a major concern in the clinic and hampers the use of available treatments as well as the development of innovative medicines. It is typically disco
Publikováno v:
Archives of Toxicology. 95:3141-3141
A correction to this paper has been published: https://doi.org/10.1007/s00204-021-03090-4
Retinoid-related orphan receptor γ (RORγ) adult induced knockout mice develop lymphoblastic lymphoma
Autor:
Camilla Johansson, Magnus Söderberg, Jenny Börjesson, Jorrit J. Hornberg, Marie Ramnegård, Maria Rehnberg, Maria Liljevald, Donatella Luciani, Johan Jirholt, Ulf Andersson, Lena Brändén, David J. Keeling, Anna-Karin Sjögren, Xiufeng Xu, Nina Krutrök, Mikael Bjursell
Publikováno v:
Autoimmunity Reviews. 15:1062-1070
RORγ is a nuclear hormone receptor which controls polarization of naive CD4+ T-cells into proinflammatory Th17 cells. Pharmacological antagonism of RORγ has therapeutic potential for autoimmune diseases; however, this mechanism may potentially carr
Publikováno v:
C58. MECHANISMS OF PULMONARY FIBROSIS.