Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jorn Lotsch"'
Autor:
Jorn Lotsch, Benjamin Mayer
Publikováno v:
BioMedInformatics; Volume 2; Issue 4; Pages: 544-552
Knowledge discovery in biomedical data using supervised methods assumes that the data contain structure relevant to the class structure if a classifier can be trained to assign a case to the correct class better than by guessing. In this setting, acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455527be1a2ab45d566097411948a0e5
https://doi.org/10.3390/biomedinformatics2040034
https://doi.org/10.3390/biomedinformatics2040034
Gender differences in pain perception have been extensively studied, while precision medicine applications such as gender-specific pain pharmacology have barely progressed beyond proof-of-concept. A data set comprising pain thresholds to mechanical (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6cd220ee3c64276da8603fff37a02b4
https://doi.org/10.21203/rs.3.rs-2398337/v1
https://doi.org/10.21203/rs.3.rs-2398337/v1
Autor:
Jörn Lötsch, Khayal Gasimli, Sebastian Malkusch, Lisa Hahnefeld, Carlo Angioni, Yannick Schreiber, Sandra Trautmann, Saskia Wedel, Dominique Thomas, Nerea Ferreiros Bouzas, Christian H Brandts, Benjamin Schnappauf, Christine Solbach, Gerd Geisslinger, Marco Sisignano
Publikováno v:
eLife, Vol 13 (2024)
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present study aimed to identify th
Externí odkaz:
https://doaj.org/article/2f70ecc6b60c49e0aa4c7ee6c353f55a
Autor:
Samuel Rischke, Sorwe Mojtahed Poor, Robert Gurke, Lisa Hahnefeld, Michaela Köhm, Alfred Ultsch, Gerd Geisslinger, Frank Behrens, Jörn Lötsch
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Psoriatic arthritis (PsA) is a chronic inflammatory systemic disease whose activity is often assessed using the Disease Activity Score 28 (DAS28-CRP). The present study was designed to investigate the significance of individual components wi
Externí odkaz:
https://doaj.org/article/821a09d2f9b24706ab9ff1d94ec2c98d
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Fibromyalgia patients vary in clinical phenotype and treatment can be challenging. The pathophysiology of fibromyalgia is incompletely understood but appears to involve metabolic changes at rest or in response to stress. We enrolled 54 fibro
Externí odkaz:
https://doaj.org/article/0b7ccc93e9d34b70bab4dc336d4119a2
Autor:
Jörn Lötsch, Alfred Ultsch
Publikováno v:
BioMedInformatics, Vol 3, Iss 4, Pp 869-884 (2023)
Recent advances in mathematical modeling and artificial intelligence have challenged the use of traditional regression analysis in biomedical research. This study examined artificial data sets and biomedical data sets from cancer research using binom
Externí odkaz:
https://doaj.org/article/8a27d3713a5247ce8ba2ba37d382e3d5
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Random walks describe stochastic processes characterized by a sequence of unpredictable changes in a random variable with no correlation to past changes. This report describes the random walk component of a clinical sensory test of olfactory
Externí odkaz:
https://doaj.org/article/cf9cc8e3ed224d908c63d1982005e585
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1639 (2024)
Background: Fold change is a common metric in biomedical research for quantifying group differences in omics variables. However, inconsistent calculation methods and inadequate reporting lead to discrepancies in results. This study evaluated various
Externí odkaz:
https://doaj.org/article/6111bad6fc584f979d1ad191bc9c6068
Autor:
Jörn Lötsch, Alfred Ultsch
Publikováno v:
Informatics in Medicine Unlocked, Vol 50, Iss , Pp 101573- (2024)
Background: Clustering on projected data is common in biomedical research analysis. Principal component analysis (PCA) is widely used for projection, focusing on data dispersion (variance), while clustering identifies data concentrations (neighborhoo
Externí odkaz:
https://doaj.org/article/65010c4faca54387ad9a50b672bcb3d9
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Sex differences in pain perception have been extensively studied, but precision medicine applications such as sex-specific pain pharmacology have barely progressed beyond proof-of-concept. A data set of pain thresholds to mechanical (blunt a
Externí odkaz:
https://doaj.org/article/e8a9114e078844b29ba3ede629c69d08