Zobrazeno 1 - 10
of 629
pro vyhledávání: '"Jorma Toppari"'
Autor:
Inna Starskaia, Milla Valta, Sami Pietilä, Tomi Suomi, Sirpa Pahkuri, Ubaid Ullah Kalim, Omid Rasool, Emilie Rydgren, Heikki Hyöty, Mikael Knip, Riitta Veijola, Jorma Ilonen, Jorma Toppari, Johanna Lempainen, Laura L. Elo, Riitta Lahesmaa
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Previous studies have revealed heterogeneity in the progression to clinical type 1 diabetes in children who develop islet-specific antibodies either to insulin (IAA) or glutamic acid decarboxylase (GADA) as the first autoantibodies. Here, we
Externí odkaz:
https://doaj.org/article/b06e835f5b7a4485812aa6eb1125e943
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/be3673a2e78d4eb29e6e7f5754eeb532
Autor:
Jake Lin, Elaheh Moradi, Karoliina Salenius, Suvi Lehtipuro, Tomi Häkkinen, Jutta E. Laiho, Sami Oikarinen, Sofia Randelin, Hemang M. Parikh, Jeffrey P. Krischer, Jorma Toppari, Åke Lernmark, Joseph F. Petrosino, Nadim J. Ajami, Jin-Xiong She, William A. Hagopian, Marian J. Rewers, Richard E. Lloyd, Kirsi J. Rautajoki, Heikki Hyöty, Matti Nykter, the TEDDY Study Group
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood t
Externí odkaz:
https://doaj.org/article/80ebd0159183481dafbd9063fd5905f9
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidi
Externí odkaz:
https://doaj.org/article/68aaaab58c3d4660904f5e1fa2aa0639
Autor:
M. Karoliina Hirvonen, Niina Lietzén, Robert Moulder, Santosh D. Bhosale, Jaakko Koskenniemi, Mari Vähä-Mäkilä, Mirja Nurmio, Matej Orešič, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Heikki Hyöty, Harri Lähdesmäki, Mikael Knip, Lu Cheng, Riitta Lahesmaa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of the beta cell damaging p
Externí odkaz:
https://doaj.org/article/b6633caddd254935bc71cb27ff2170c4
Autor:
Sirpa Pahkuri, Ilse Ekman, Céline Vandamme, Kirsti Näntö-Salonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Tuure Kinnunen, Jorma Ilonen, Johanna Lempainen
Publikováno v:
Autoimmunity, Vol 56, Iss 1 (2023)
We elucidated the effect of four known T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in INS and rs2476601 in PTPN22) on CpG site methylation of their proximal promo
Externí odkaz:
https://doaj.org/article/c6cd5e4bd4fe4b9e8707519eb5c35fa8
Autor:
Lucas Nygård, Milla Valta, Antti-Pekka Laine, Jorma Toppari, Mikael Knip, Riitta Veijola, Heikki Hyöty, Jorma Ilonen, Johanna Lempainen
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Enteroviral infections have been linked to the development of islet autoimmunity (IA) and type 1 diabetes (T1D), and the coxsackie and adenovirus receptor (CXADR) is one of the ligands used by adenoviruses and enteroviruses for cell internalization.
Externí odkaz:
https://doaj.org/article/717bf1d385f44429bfe274826062fdc5
Autor:
Santosh Lamichhane, Partho Sen, Alex M. Dickens, Matilda Kråkström, Jorma Ilonen, Johanna Lempainen, Heikki Hyöty, Riitta Lahesmaa, Riitta Veijola, Jorma Toppari, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Aims/hypothesisAppearance of multiple islet cell autoantibodies in early life is indicative of future progression to overt type 1 diabetes, however, at varying rates. Here, we aimed to study whether distinct metabolic patterns could be identified in
Externí odkaz:
https://doaj.org/article/3580584f61c242bda4a93b24851cb332
Autor:
Essi Laajala, Viivi Halla-aho, Toni Grönroos, Ubaid Ullah Kalim, Mari Vähä-Mäkilä, Mirja Nurmio, Henna Kallionpää, Niina Lietzén, Juha Mykkänen, Omid Rasool, Jorma Toppari, Matej Orešič, Mikael Knip, Riikka Lund, Riitta Lahesmaa, Harri Lähdesmäki
Publikováno v:
Epigenetics, Vol 17, Iss 12, Pp 1608-1627 (2022)
DNA methylation patterns are largely established in-utero and might mediate the impacts of in-utero conditions on later health outcomes. Associations between perinatal DNA methylation marks and pregnancy-related variables, such as maternal age and ge
Externí odkaz:
https://doaj.org/article/667134eacf774c6e931b0432d4c2ea31
Autor:
Anna-Mari Schroderus, Josh Poorbaugh, Samantha McElyea, Stephanie Beasley, Lin Zhang, Kirsti Näntö-Salonen, Reeta Rintamäki, Jussi Pihlajamäki, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Robert J. Benschop, Tuure Kinnunen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IL-21 is a multifunctional cytokine linked with the pathophysiology of several autoimmune diseases, including type 1 diabetes. In this study, our aim was to examine plasma IL-21 levels in individuals at different stages of type 1 diabetes progression
Externí odkaz:
https://doaj.org/article/b555d9125ad4498f8dc8f29fb83c028e