Zobrazeno 1 - 10
of 326
pro vyhledávání: '"Jorma Isola"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Eccrine porocarcinoma (EPC) is a rare malignant adnexal tumour of the skin. Part of EPCs develop from their benign counterpart, poroma (EP), with chronic light exposure and immunosuppression hypothesized to play a role in the malignant trans
Externí odkaz:
https://doaj.org/article/99dd7dc725934cc18ee3063005cac510
Autor:
Jorma Isola, Markku Mäki, Martin Hils, Ralf Pasternack, Keijo Viiri, Valeriia Dotsenko, Toni Montonen, Timo Zimmermann, Ralf Mohrbacher, Roland Greinwald, Detlef Schuppan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10815 (2023)
The enzyme transglutaminase 2 (TG2) plays a key role in celiac disease (CeD) pathogenesis. Active TG2 is located mainly extracellularly in the lamina propria but also in the villous enterocytes of the duodenum. The TG2 inhibitor ZED1227 is a promisin
Externí odkaz:
https://doaj.org/article/69ecaf196bd7478da0fda56818c05fdb
Autor:
Elisa Närvä, Maria E. Taskinen, Sergio Lilla, Aleksi Isomursu, Mika Pietilä, Jere Weltner, Jorma Isola, Harri Sihto, Heikki Joensuu, Sara Zanivan, Jim Norman, Johanna Ivaska
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104459- (2022)
Summary: MASTL is a mitotic accelerator with an emerging role in breast cancer progression. However, the mechanisms behind its oncogenicity remain largely unknown. Here, we identify a previously unknown role and eminent expression of MASTL in stem ce
Externí odkaz:
https://doaj.org/article/49fc6d2d2b354fafb82f10b872696eca
Autor:
Dmitrii Bychkov, Nina Linder, Aleksei Tiulpin, Hakan Kücükel, Mikael Lundin, Stig Nordling, Harri Sihto, Jorma Isola, Tiina Lehtimäki, Pirkko-Liisa Kellokumpu-Lehtinen, Karl von Smitten, Heikki Joensuu, Johan Lundin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The treatment of patients with ERBB2 (HER2)-positive breast cancer with anti-ERBB2 therapy is based on the detection of ERBB2 gene amplification or protein overexpression. Machine learning (ML) algorithms can predict the amplification of ERB
Externí odkaz:
https://doaj.org/article/a11d9a652e1d4a5abc61c46e6c7eca99
Autor:
Valeriia Dotsenko, Mikko Oittinen, Juha Taavela, Alina Popp, Markku Peräaho, Synnöve Staff, Jani Sarin, Francisco Leon, Jorma Isola, Markku Mäki, Keijo Viiri
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 13-32 (2021)
Background & Aims: Gluten challenge studies are instrumental in understanding the pathophysiology of celiac disease. Our aims in this study were to reveal early gluten-induced transcriptomic changes in duodenal biopsies and to find tools for clinics.
Externí odkaz:
https://doaj.org/article/903f1c5952eb4cb0ba7ff22dc96ad2f9
Autor:
Dmitrii Bychkov, Heikki Joensuu, Stig Nordling, Aleksei Tiulpin, Hakan Kücükel, Mikael Lundin, Harri Sihto, Jorma Isola, Tiina Lehtimäki, Pirkko-Liisa Kellokumpu-Lehtinen, Karl von Smitten, Johan Lundin, Nina Linder
Publikováno v:
Journal of Pathology Informatics, Vol 13, Iss , Pp 100171- (2022)
Background: Prediction of clinical outcomes for individual cancer patients is an important step in the disease diagnosis and subsequently guides the treatment and patient counseling. In this work, we develop and evaluate a joint outcome and biomarker
Externí odkaz:
https://doaj.org/article/86d6124f70db459fa8e60f874fc34f05
Autor:
Juha Taavela, Keijo Viiri, Alina Popp, Mikko Oittinen, Valeriia Dotsenko, Markku Peräaho, Synnöve Staff, Jani Sarin, Francisco Leon, Markku Mäki, Jorma Isola
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background There is an unmet need for novel treatments, such as drugs or vaccines, adjunctive to or replacing a burdensome life-long gluten-free diet for coeliac disease. The gold standard for successful treatment is a healed small intestina
Externí odkaz:
https://doaj.org/article/8c0ba4ac103841a88a91d20b653f154e
Autor:
Juha Taavela, Keijo Viiri, Anna Välimäki, Jani Sarin, Kristiina Salonoja, Markku Mäki, Jorma Isola
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Histological evaluation of the small intestinal mucosa is the cornerstone of celiac disease diagnostics and an important outcome in scientific studies. Gluten-dependent injury can be evaluated either with quantitative morphometry or grouped classific
Externí odkaz:
https://doaj.org/article/c0da0297d9e6497fa323be85b1462c22
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-19 (2018)
Abstract Background Human epidermal growth factor receptor HER3 (ErbB3), especially in association with its relative HER2 (ErbB2), is known as a key oncogene in breast tumour biology. Nonetheless, the prognostic relevance of HER3 remains controversia
Externí odkaz:
https://doaj.org/article/30242b069b89449596a044529eeb493b
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that carries a cytotoxic drug (DM1) to HER2-positive cancer. The target of T-DM1 (HER2) is present also on cancer-derived exosomes. We hypothesized that exosome-bound T-D
Externí odkaz:
https://doaj.org/article/5e7c9937327e48098ffdd421d894b730