Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jorma Hassfeld"'
Autor:
Alexandros Vakalopoulos, Frank Wunder, Ingo V. Hartung, Gorden Redlich, Rolf Jautelat, Philipp Buchgraber, Jorma Hassfeld, Alexey V. Gromov, Niels Lindner, Donald Bierer, Jörg Gries, Walter Kroh, Holger Paulsen, Joachim Mittendorf, Dieter Lang, Eva Becker-Pelster, Damian Brockschnieder, Volker Geiss, Volkhart Li, Alexander Straub, Andreas Knorr, Thomas Mondritzki, Hubert Trübel, Marian Raschke, Martina Schaefer, Dirk Thomas, Peter Sandner, Johannes-Peter Stasch, Markus Follmann
Publikováno v:
Journal of Medicinal Chemistry.
Publikováno v:
Organic Process Research & Development. 24:255-260
Herein, we report the first example of the asymmetric hydrogenation of a prochiral benzodiazepine substrate as key transformation in a pilot-scale synthesis of BET inhibitor BAY 1238097. High-throu...
Publikováno v:
Organic Process Research & Development. 21:2060-2067
Within practically all multistep synthetic sequences used to prepare molecular entities, a step can be found in which a change of solvent is required. Presently this is nearly always carried out by distillation process. Alternatives to distillation d
Autor:
Jorma Hassfeld, Todor Baramov, Hermann Bauer, Michael Gottfried, Tanja Herrmann, Stefan Roggan, Mourad Ben Said
Publikováno v:
European Journal of Organic Chemistry. 2017:3921-3928
The chemoselective, continuous, multistep reduction of iodo-nitroaromatics in a fixed-bed hydrogenation reactor has been investigated. This transformation poses challenges upon both the catalyst and process conditions if high yields are to be achieve
Autor:
Tanmay Godiawala, Patrick Loos, Jorma Hassfeld, Hannes Alex, John Barry, Norbert Steinfeldt, Todor Baramov
Publikováno v:
ChemCatChem. 9:3210-3217
New cobalt catalysts confined in an EnCatTM polyurea matrix by micro-encapsulation of Al5Co2 or Al5Co2/Al3Ni2 phase containing alloys are disclosed for the reductive hydrogenation of 1-iodo-4-nitrobenzene 1. The product 4-iodo-aniline 2 readily under
Autor:
Jorma Hassfeld, Stefan Roggan, Todor Baramov, Tanja Herrmann, Mourad Ben Said, Michael Gottfried
Publikováno v:
Organic Process Research & Development. 21:705-714
The continuous selective hydrogenation of the iodo-nitroaromatic refametinib active pharmaceutical ingredient (API) intermediate (2,3-difluoro-5-methoxy-6-nitro-phenyl)-(2-fluoro-4-iodo-phenyl)-amine (DIM-NA) to the corresponding iodo-aniline 3,4-dif
Autor:
Philipp Rubenbauer, Richard N. S. van der Haas, Jorma Hassfeld, Dekker Jeroen Alexander, Eric W. P. Damen, Anastasia Hager, Peter Fey
Publikováno v:
Synthesis. 49:2394-2401
An improved synthesis of the bicyclic spiro compound 2-oxa-6-azaspiro[3.3]heptane is presented. While this compound is often isolated as an oxalate salt, its isolation as a sulfonic acid salt yields a more stable and more soluble product. With these
Autor:
Michael Gottfried, Jorma Hassfeld, Tobias Stemmler, Matthias Beller, Gregor Meier, Hannes Alex, Stefan Roggan, Todor Baramov, Patrick Loos
Publikováno v:
Advanced Synthesis & Catalysis. 358:2903-2911
A carbon nanotube supported catalyst containing cobalt/cobalt oxide (Co/Co3O4) nanoparticles encapsulated within a shell of nitrogen-doped graphene layers (Co3O4/NGr@CNT) was prepared. It shows excellent chemoselectivity in the hydrogenation of 1-iod
Autor:
Sandra Hübner, Johannes Platzek, Jorma Hassfeld, Norbert Steinfeldt, Patrick Loos, Kai Lovis, Hannes Alex
Publikováno v:
Organic Process Research & Development. 20:452-464
The selective hydrogenation of functionalized nitroaromatics poses a major challenge from both academic as well as industrial viewpoints. As part of the CHEM21 initiative (www.chem21.eu), we are interested in highly selective, catalytic hydrogenation
Autor:
Martina Schäfer, Heribert Schmitt-Willich, Markus Berger, Gregor Jost, Hubertus Pietsch, Thomas Frenzel, Marcus Bauser, Detlev Sülzle, Jorma Hassfeld
Publikováno v:
Journal of Cluster Science. 26:111-118
In recognition of the seminal contributions of F. A. Cotton and A. Bino to the field of aqueous chemistry of organometallic, trinuclear cluster compounds of tungsten, we describe their modifications and use as contrast agents for X-ray computed tomog