Výsledky vyhledávání - "Joris R Julsing"

Akademický článek

The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.

Autor: Dzjemma Sarkisjan, Joris R Julsing, Kees Smid, Daniël de Klerk, André B P van Kuilenburg, Rutger Meinsma, Young B Lee, Deog J Kim, Godefridus J Peters

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0162901 (2016)

Fluorocyclopentenylcytosine (RX-3117) is an orally available cytidine analog, currently in Phase I clinical trial. RX-3117 has promising antitumor activity in various human tumor xenografts including gemcitabine resistant tumors. RX-3117 is activated

Externí odkaz: https://doaj.org/article/ecd36541f4fd43e4b410765524e870bd

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Rx-3117 (Fluorocyclopentenyl-cytosine)-mediated down-regulation of dna methyltransferase 1 leads to protein expression of tumor-suppressor genes and increased functionality of the proton-coupled folate carrier

Autor: Larry H. Matherly, Young Bok Lee, Joris R. Julsing, Dzjemma Sarkisjan, Btissame El Hassouni, Godefridus J. Peters, Deog Joong Kim, Ietje Kathmann, Richard J. Honeywell

Publikováno v: Sarkisjan, D, Julsing, J R, El Hassouni, B, Honeywell, R J, Kathmann, I, Matherly, L H, Lee, Y B, Kim, D J & Peters, G J 2020, ' Rx-3117 (Fluorocyclopentenyl-cytosine)-mediated down-regulation of dna methyltransferase 1 leads to protein expression of tumor-suppressor genes and increased functionality of the proton-coupled folate carrier ', International Journal of Molecular Sciences, vol. 21, no. 8, 2717 . https://doi.org/10.3390/ijms21082717
International Journal of Molecular Sciences
Volume 21
Issue 8
International Journal of Molecular Sciences, 21(8):2717. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 2717, p 2717 (2020)

(1) Background: RX-3117 (fluorocyclopentenyl-cytosine) is a cytidine analog that inhibits DNA methyltransferase 1 (DNMT1). We investigated the mechanism and potential of RX-3117 as a demethylating agent in several in vitro models. (2) Methods: we use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0b844558a3fc411cacfcb3190c8d10
https://research.vumc.nl/en/publications/038cd18b-dcaa-4848-94b5-1a8098b9efcb

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Abstract 1267: Unusual mechanism of resistance to the novel cytidine analog fluorocyclopentenylcytosine (RX-3117)

Autor: Elisa Giovannetti, Young Bok Lee, Godefridus J. Peters, Daniel J. De Klerk, Dzjemma Sarkisjan, Kees Smid, Deog Joong Kim, Btissame El Hassouni, Joris R. Julsing, Safet Zekanovic, Richard J. Honeywell, Beatrice Balboni

Publikováno v: Cancer Research. 79:1267-1267

RX-3117 is a novel cytidine analog showing encouraging results in ongoing Phase 2a studies with gemcitabine-resistant pancreatic ductal adenocarcinoma and advanced urothelial bladder cancer. Cellular uptake of RX-3117 is mediated by the equilibrative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0216442f614b1622fcd3bee87f0949f
https://doi.org/10.1158/1538-7445.am2019-1267

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The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2

Autor: Rutger Meinsma, Young Bok Lee, Joris R. Julsing, Dzjemma Sarkisjan, Daniel de Klerk, Kees Smid, Deog Joong Kim, Godefridus J. Peters, André B.P. van Kuilenburg

Publikováno v: PLoS ONE, 11(9). Public Library of Science
Sarkisjan, D, Julsing, J R, Smid, K, de Klerk, D, van Kuilenburg, A B P, Meinsma, R, Lee, Y B, Kim, D J & Peters, G J 2016, ' The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2 ', PLoS ONE, vol. 11, no. 9 . https://doi.org/10.1371/journal.pone.0162901
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0162901 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89172426006ecc70eba60f075b608615
https://research.vumc.nl/en/publications/b5036ec3-8627-4d40-8e05-b3cf3247d794

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Munc18-1 haploinsufficiency results in enhanced anxiety-like behavior as determined by heart rate responses in mice

Autor: Gregoire Maroteaux, Joris R. Julsing, Oliver Stiedl, Rick van Vliet, Paula du Pont, Torben Hager

Publikováno v: Hager, T, Maroteaux, G P, Pont, P D, Julsing, J, van Vliet, R & Stiedl, O 2014, ' Munc18-1 haploinsufficiency results in enhanced anxiety-like behavior as determined by heart rate responses in mice ', Behavioural Brain Research, vol. 260, pp. 44-52 . https://doi.org/10.1016/j.bbr.2013.11.033
Behavioural Brain Research, 260, 44-52. Elsevier

Heterozygous (HZ) missense mutations in the gene encoding syntaxin binding protein 1 (Stxbp1 or Munc18-1), a presynaptic protein essential for neurotransmitter release, causes early infantile epileptic encephalopathy, abnormal brain structure and men

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d023f5e77ad04ae9a853538b56a4f6c
https://research.vu.nl/en/publications/24d1ba57-8194-4c44-880f-f622e9caec70

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Abstract 2622: Fluorocyclopentenylcytosine (RX-3117) is activated by uridine-cytidine kinase 2, a potential biomarker

Autor: Mi Y. Yang, Dzjemma Sarkisjan, Daniel de Klerk, Kees Smid, Godefridus J. Peters, Young Bok Lee, Joris R. Julsing, Deog Joong Kim

Publikováno v: Cancer Research. 75:2622-2622

Fluorocyclopentenylcytosine (RX-3117) is an orally bioavailable novel cytidine analog, currently being tested in a Phase I clinical trial. RX-3117 shows promising antitumor activity in various human tumor xenografts including patient derived xenograf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25c7eea05aafaedeb4012f316a68686c
https://doi.org/10.1158/1538-7445.am2015-2622

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