Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Joris K"'
Autor:
Melissa Stunnenberg, Joris K. Sprokholt, John L. van Hamme, Tanja M. Kaptein, Esther M. Zijlstra-Willems, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Strong innate and adaptive immune responses are paramount in combating viral infections. Dendritic cells (DCs) detect viral infections via cytosolic RIG-I like receptors (RLRs) RIG-I and MDA5 leading to MAVS-induced immunity. The DEAD-box RNA helicas
Externí odkaz:
https://doaj.org/article/fd20377470564fb0a29ea1ba5bcc16a1
Autor:
Melissa Stunnenberg, Lisa van Pul, Joris K. Sprokholt, Karel A. van Dort, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek, Neeltje A. Kootstra
Publikováno v:
Viruses, Vol 12, Iss 7, p 764 (2020)
The mitochondrial antiviral protein MAVS is a key player in the induction of antiviral responses; however, human immunodeficiency virus 1 (HIV-1) is able to suppress these responses. Two linked single nucleotide polymorphisms (SNPs) in the MAVS gene
Externí odkaz:
https://doaj.org/article/5e0729a89e67458e89bd07ae1f7bb3a6
Autor:
Joris K Sprokholt, Tanja M Kaptein, John L van Hamme, Ronald J Overmars, Sonja I Gringhuis, Teunis B H Geijtenbeek
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006738 (2017)
Follicular T helper cells (TFH) are fundamental in orchestrating effective antibody-mediated responses critical for immunity against viral infections and effective vaccines. However, it is unclear how virus infection leads to TFH induction. We here s
Externí odkaz:
https://doaj.org/article/8fb71dd840f84d5f831fe88badab0ad3
Autor:
Joris K Sprokholt, Marieke H Heineke, Tanja M Kaptein, John L van Hamme, Teunis B H Geijtenbeek
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185580 (2017)
Microbial DNA is highly immunostimulatory and is sensed by endosomal pattern recognition receptors after release from internalized microbes. It is unclear how extracellular DNA released from dead microbes is delivered to endosomal PRRs to induce immu
Externí odkaz:
https://doaj.org/article/8f050f44d47b443193734c8e9d96dcb0
Autor:
Wendy Niedelman, Daniel A Gold, Emily E Rosowski, Joris K Sprokholt, Daniel Lim, Ailan Farid Arenas, Mariane B Melo, Eric Spooner, Michael B Yaffe, Jeroen P J Saeij
Publikováno v:
PLoS Pathogens, Vol 8, Iss 6, p e1002784 (2012)
The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host cell that manipulate the immune response allowing it to establish a chronic infection. Crosses between the types I, II and III strains, which are prevalent
Externí odkaz:
https://doaj.org/article/8d15070ac0ea4b4a99ca429118b77d59
Autor:
Helgers, Leanne C., Keijzer, Nadia C.H., van Hamme, John L., Sprokholt, Joris K., Geijtenbeek, Teunis B.H.
Publikováno v:
In Journal of Investigative Dermatology May 2024 144(5):1099-1111
Publikováno v:
In Water Research X 1 December 2018 1
Autor:
Ilaria Signoria, Maria M. Zwartkruis, Lotte Geerlofs, Elena Perenthaler, Kiterie M.E. Faller, Rachel James, Harriet McHale-Owen, Jared W. Green, Joris Kortooms, Sophie H. Snellen, Fay-Lynn Asselman, Thomas H. Gillingwater, Gabriella Viero, Renske I. Wadman, W. Ludo van der Pol, Ewout J.N. Groen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101379- (2024)
The availability of three therapies for the neuromuscular disease spinal muscular atrophy (SMA) highlights the need to match patients to the optimal treatment. Two of these treatments (nusinersen and risdiplam) target splicing of SMN2, but treatment
Externí odkaz:
https://doaj.org/article/3b66cab32cd941798ce4e53baf5f714a
Autor:
Irena Beidler, Nicola Steinke, Tim Schulze, Chandni Sidhu, Daniel Bartosik, Marie-Katherin Zühlke, Laura Torres Martin, Joris Krull, Theresa Dutschei, Borja Ferrero-Bordera, Julia Rielicke, Vaikhari Kale, Thomas Sura, Anke Trautwein-Schult, Inga V. Kirstein, Karen H. Wiltshire, Hanno Teeling, Dörte Becher, Mia Maria Bengtsson, Jan-Hendrik Hehemann, Uwe. T. Bornscheuer, Rudolf I. Amann, Thomas Schweder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Phytoplankton blooms provoke bacterioplankton blooms, from which bacterial biomass (necromass) is released via increased zooplankton grazing and viral lysis. While bacterial consumption of algal biomass during blooms is well-studied, little
Externí odkaz:
https://doaj.org/article/e17e8a4f63ef45ea8045d12a7c6be836